Biliary Sludge as a Cause of Acute Pancreatitis

Lee, Sum P.; Nicholls, Jane F.; Park, Han Z.

doi:10.1056/nejm199202273260902

Cited by 462 publications

(225 citation statements)

References 16 publications

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“…Subjects treated with placebo showed a significant increase in the number of severely damage mitochondria after reperfusion, whereas the number of damaged and necrotic myocytes also increased significantly in these subjects after infusion. No such damage to mitochondria or myocytes was observed in the taurine treated subjects (Lee et al, 1992). The use of supplemental taurine as a physiological protective against lipid peroxidation was advocated by Gordon et al (1986) who demonstrated the protection of hamaster bronchioles from acute NO 2 -induced alterations.…”

Section: Discussionmentioning

confidence: 91%

“…It was proposed by Gordon et al (1986) and Cardin et al (1999) that the protective activity of taurine may reside in its ability to become chlorinated in the presence of HOCL, thereby preventing the direct attack of this oxidant on cell membranes (Rock et al, 1996). Lee et al (1992) postulated that the protective action of taurine on oxidant-induced damages of tissue components including degradation of hyaluronic acid may be attributed to both its scavenging action on hypochloriate (HOCl) and chloramine and the complex formation of taurine with HOCl or NH2Cl without scavenging action on oxygen free radicals.…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in Rat

Issabeagloo¹,

Taghizadiyeh²,

Kermanizadeh³

2011

American Journal of Animal and Veterinary Sciences

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Problem statement: Taurine, 2-aminoethanesulphonic acid is an essential amino acid. It is present at high concentrations in many tissues. It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels and maintenance of osmolarity, antioxidation and stabilization of membranes. Methotrexate (MTX), as the most disease modifying anti-rheumatic drug used for Rheumatoid Arthritis (RA), has been available for clinical use since 1951. The main scope of this study was to assessment of probable Hepatoprotective effect of taurine as it antioxidant action against oxidative stress due to methotrexate in rats. Approach: Eighty male Wistar rats, weighing 200±20 gr, were obtained from the animal breeding center of Islamic Azad University. The rats were divided into 4 equal groups of 20 animals including: 1-normal control, 2-normal rats treated with taurine, 3-taurine + methotrexate and 4-methotrexate. Results: Methotrexateinduced hepatotoxicity as reflected by elevated serum ALT, AST and GGT levels (p<0.001) and reduced serum total protein level (p<0.001). Conclusion: Taurine has a protective action against hepatotoxins and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in Rat

Issabeagloo¹,

Taghizadiyeh²,

Kermanizadeh³

2011

American Journal of Animal and Veterinary Sciences

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“…It forms a dense layer in the gallbladder. Behaving similarly to gallstones, it may cause acute pancreatitis and similarly, cleaning coledoc using cholecystectomy and ERCP may prevent recurrent pancreatitis attacks [24,25]. Experimental studies have demonstrated that biliary reflux was not a necessity for acute pancreatitis development, and pancreatitis may develop as a result of pancreatic duct obstruction [26].…”

Section: Pathophyisiologymentioning

confidence: 99%

Contemporary Management of Acute Biliary Pancreatitis

Özkan¹

2015

Ann Clin Anal Med

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ÖzetAkut biliary pankreatit, en yaygın akut pankreatit nedenlerindendir. Safra taş-ları, safra çamuru, özellikle nedeni saptanamayanlarda mikrolityazis pankreatit nedeni olabilmektedir. Akut biliyer pankreatit konusu literatürde çok tartışmalı yönleri olan ve sınıflandırma ve klavuzları çok hızlı değişen bir konudur .Akut pankreatit ile ilgili tanımlamaların ve klasifikasyonların yapıldığı Atlanta kriterleri yenilenerek 2013 yılında yayınlanmıştır. Akut biliyer pankreatitte çok kolay tedavi edilebilen hafif şeklinden mortaliteye neden olan komplikasyonlara yo laçan ağır şekline kadar geniş bir spectrum vardır. Bu hastalığın patogenesi tam olarak aydınlatılamamış ve çeşitli teoriler ileri sürülmüştür.Gerek tanı gerekse ağırlık derecesini tahmin etmek için protemiks gibi yeni laboratuar yöntemleri ve skorlama sistemleri önerilmiş ve bunlarla ilgili ça-lışmalar devam etmektedir. ERCP, ES, MRCP, EUS gibi teknolojik gelişmelerle ilişkili yeni tedavi yaklaşımları önerilmektedir. Anahtar KelimelerAkut Bilayer Pankreatit; Tanı; Ağırlığıöngörme; Tedavi AbstractAcute biliary pancreatitis is one of the major causes of acute pancreatitis.Gallstones, biliary sludge and microlithiasis, especially in pancreatitis without detectable reason, can be the cause of acute pancreatitis. Acute biliary pancreatitis has many controversions in the literature, and its classification and guidelines are being updated very frequently. Atlanta classifications which determine the definitions and guidelines about acute pancreatitis were renewed and published in 2013. It has various clinical aspects, ranging from a mild form which is easily treated, to a severe form that causes complications leading to mortality. The pathogenesis of this disease has not been fully elucidated and several theories have been suggested. New scoring systems and laboratory methods such as proteomics have been suggested for both diagnosis and to predict disease severity, and research on these topics is still in progress. Novel therapeutic approaches with technological developments such as ERCP, ES, MRCP, and EUS are also suggested.

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“…This sediment consists of cholesterol crystals, calcium bilirubinate pigment, and other calcium salts [21]. Biliary sludge is usually detected on transabdominal ultrasonography: produces a mobile, low amplitude echo,without acoustic shadow.…”

Section: Biliary Sludge and Microlithiasismentioning

confidence: 99%

Etiology of acute pancreatitis

2014

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AbstractAcute pancreatitis is a common disease with a benign course in the majority of patients, but it is associated with serious morbidity, and mortality close to 20% in up to 20% of cases. The incidence of acute pancreatitis seems to be rising in western countries. About 75% of all cases are caused by gallstones or alcoholism. The relative rate of gallstones versus alcohol as etiology depends on the age and the area of enrolment. A thorough evaluation allows cause identification in another 10% of cases, leaving about 15–20% as idiopathic. The most common causes, and a growing list of less frequent and sometimes very rare and controversial etiologies, are reviewed in this article. A classification on the pathogenic mechanisms of causes of acute pancreatitis based is used in this Review. The approach, or suggested plan of investigations, to determine the etiology of acute pancreatitis, based on the most recently published Guidelines is outlined.

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Biliary Sludge as a Cause of Acute Pancreatitis

Abstract: Biliary sludge is an underestimated cause of acute idiopathic pancreatitis.

Cited by 462 publications

References 16 publications

Hepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in Rat

Hepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in Rat

Contemporary Management of Acute Biliary Pancreatitis

Etiology of acute pancreatitis

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