Biliary heavy metal concentrations in carcinoma of the gall bladder: case-control study

Shukla, Vijay K.; Prakash, Apurva; Tripathi, B. D.; Reddy, D. C. S.; Singh, Satnam

doi:10.1136/bmj.317.7168.1288

Cited by 55 publications

(43 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various risk factors like cholelithiasis [2], external carcinogens [3,4], free radicals, secondary bile acids [5], lipid peroxidation products [6], and heavy metals [7] have been proposed in its pathogenesis but none has stood the test of time. Micronutrients and antioxidants have assumed an important protective role in carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Micronutrients, antioxidants, and carcinoma of the gallbladder

Shukla

Adukia

Singh

et al. 2003

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Micronutrients, antioxidants, and carcinoma of the gallbladder

Shukla

Adukia

Singh

et al. 2003

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Long-term exposure to Rn by inhalation has been linked to respiratory disorders, such as lung disease and lung cancer, in humans (Field et al, 2000(Field et al, , 2001. Some of the trace elements, such as Cd, Cr, Pb and As, and compounds that contain them are known to be carcinogenic (Smith et al, 1992;Shukla et al, 1998;Waalkes, 2003).…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to volcanic environments and cancer incidence in the Azores, Portugal

Amaral

Rodrigues

Oliveira³

et al. 2006

Science of The Total Environment

View full text Add to dashboard Cite

Whether volcanic environments pose a risk in cancer incidence is unknown. We investigated this question in two populations, one from an area with active manifestations of volcanism (Furnas) and another from an area without volcanic activity since 3 million years ago (Santa Maria), both in Azores. Incidence data on cancer among the populations of Furnas and Santa Maria during 1991-2001 were obtained from medical records of local health centers. Age-standardized rates and relative risks were estimated. Overall incidence rates were higher in the volcanically active area when observing all cancers and both sexes combined. However, the non-volcanically active area presented higher rates of cancer of digestive, respiratory and intrathoracic organs, mainly in males, while the area with volcanic manifestations showed higher rates of cancer of lip, oral cavity and pharynx, in both sexes, and female breast. Relative risk estimates between both populations suggest a higher risk for cancer in some groups of organs in Furnas, especially of lip, oral cavity and pharynx cancer, and breast, that may be partially explained by the chronic exposure to environmental factors resulting from volcanic activity, such as hazardous gases and aerosols, much of them associated to trace metals.

show abstract

“…Other metals are not considered essential and their presence, even at very low doses, may result in impairment of biological functions (Apostoli, 2002). For instance, Cd is carcinogenic and Pb neurotoxic, and even in small amounts both may interact with calcium and replace it in the skeleton or Zn in the heme enzymes and metallothioneins (Goyer, 1997;Shukla et al, 1998;Waalkes, 2003).…”

Section: Introductionmentioning

confidence: 99%

Essential and non-essential trace metals in scalp hair of men chronically exposed to volcanogenic metals in the Azores, Portugal

Amaral

Arruda

Cabral

et al. 2008

Environment International

View full text Add to dashboard Cite

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. Volcanoes produce and release large amounts of toxicants, and the concentration of metals in hair can be used as a biomarker of exposure to trace metals. In order to investigate whether humans exposed to volcanic emissions demonstrate higher concentrations of essential and non-essential trace metals, scalp hair of men (3-89 years) living in two areas of the Azores, one exposed to volcanic emissions and the other not, was sampled, and their content in Cd, Cu, Pb, Rb, Se, and Zn was quantified by using High Resolution Inductively Coupled Plasma Mass Spectrometry. In average, men exposed to volcanic emissions presented higher concentrations of Cd (96.9 ppb), Cu (16.2 ppm), Pb (3417.6 ppb), Rb (216.3 ppb), and Zn (242.8 ppm), but not Se (469.6 ppb). Also, strong and significant correlations were found between Cd-Rb and Pb-Rb in the exposed men. In conclusion, humans living chronically exposed to volcanic emissions show high concentrations of essential and non-essential trace metals in scalp hair, and is suggested that this type of exposure may be as harmful as living close to industrial facilities. A B S T R A C T A R T I C L E I N F O

show abstract

Biliary heavy metal concentrations in carcinoma of the gall bladder: case-control study

Cited by 55 publications

References 2 publications

Micronutrients, antioxidants, and carcinoma of the gallbladder

Micronutrients, antioxidants, and carcinoma of the gallbladder

Chronic exposure to volcanic environments and cancer incidence in the Azores, Portugal

Essential and non-essential trace metals in scalp hair of men chronically exposed to volcanogenic metals in the Azores, Portugal

Contact Info

Product

Resources

About