Bile duct clearance and cholecystectomy for choledocholithiasis: Definitive single-stage laparoscopic cholecystectomy with intraoperative endoscopic retrograde cholangiopancreatography versus staged procedures

Abstract

BACKGROUND Clinical equipoise exists regarding optimal sequencing in the definitive management of choledocholithiasis. Our current study compares sequential biliary ductal clearance and cholecystectomy at an interval to simultaneous laparoendoscopic management on index admission in a pragmatic retrospective manner. METHODS Records were reviewed for all patients admitted between January 2015 and December 2018 to a Swedish and an Irish university hospital. Both hospitals differ in their practice patterns for definitive management of choledocholithiasis. At the Swedish hospital, patients with choledocholithiasis underwent laparoscopic cholecystectomy with intraoperative rendezvous endoscopic retrograde cholangiopancreatography (ERCP) at index admission (one stage). In contrast, interval day-case laparoscopic cholecystectomy followed index admission ERCP (two stages) at the Irish hospital. Clinical characteristics, postprocedural complications, and inpatient duration were compared between cohorts. RESULTS Three hundred fifty-seven patients underwent treatment for choledocholithiasis during the study period, of whom 222 (62.2%) underwent a one-stage procedure in Sweden, while 135 (37.8%) underwent treatment in two stages in Ireland. Patients in both cohorts were closely matched in terms of age, sex, and preoperative serum total bilirubin. Patients in the one-stage group exhibited a greater inflammatory reaction on index admission (peak C-reactive protein, 136 ± 137 vs. 95 ± 102 mg/L; p = 0.024), had higher incidence of comorbidities (age-adjusted Charlson Comorbidity Index, ≥3; 37.8% vs. 20.0%; p = 0.003), and overall were less fit for surgery (American Society of Anesthesiologists, ≥3; 11.7% vs. 3.7%; p < 0.001). Despite this, a significantly shorter mean time to definitive treatment, that is, cholecystectomy (3.1 ± 2.5 vs. 40.3 ± 127 days, p = 0.017), without excess morbidity, was seen in the one-stage compared with the two-stage cohort. Patients in the one-stage cohort experienced shorter mean postprocedure length of stay (3.0 ± 4.7 vs. 5.0 ± 4.6 days, p < 0.001) and total length of hospital stay (6.5 ± 4.6 vs. 9.0 ± 7.3 days, p = 0.002). The only significant difference in postoperative complications between the cohorts was urinary retention, with a higher incidence in the one-stage cohort (19% vs. 1%, p = 0.004). CONCLUSION Where appropriate expertise and logistics exist within developing models of acute care surgery worldwide, consideration should be given to index-admission laparoscopic cholecystectomy with intraoperative ERCP for the treatment of choledocholithiasis. Our data suggest that this strategy significantly shortens the time to definitive treatment and decreases total hospital stay without any excess in adverse outcomes. LEVEL OF EVIDENCE Therapeutic/Care Management Level IV.

Patients over 65 years with Acute Complicated Calculous Biliary Disease are Treated Differently—Results and Insights from the ESTES Snapshot Audit

“…Several studies have shown better outcomes in those who received early cholecystectomy following duct clearance for gallstone pancreatitis, and the Tokyo Guidelines (2018) advise index admission cholecystectomy in this instance [26,27]. A recent comparison of one-stage ERCP and cholecystectomy versus index admission ERCP with planned interval elective day-case cholecystectomy demonstrated a readmission rate over 20% in the latter group, due to complications relating to the retained gallbladder as a stone reservoir [28]. Regrettably, our current data did not report readmission rate, but given the overlap in patient populations, we would expect similar rates of disease recidivism in the non-operated cohort.…”

Global trends of ERCP research in the last 25 years: A bibliometrics study

“…[25,26] In cholelithiasis, LC with intraoperative ERCP has been proved as a safe and feasible strategy for the management of cholelithiasis and choledocholithiasis, with less cost, shorter length of hospital stays, and shorter anesthesia time. [27][28][29] As for PEP, research is mainly focused on prophylaxis medications, such as indomethacin or diclofenac. [30] For "sphincter dysfunction," the necessity of ERCP for patients with sphincter of Oddi dysfunction (SOD) remains a controversial issue.…”

Common bile duct stones management: A network meta-analysis

“…In practice, most patients deferred from an index admission cholecystectomy are older, burdened by comorbidities, and frail, which makes managing CBD stone-related complications even more challenging. 21,[23][24][25] With a growing elderly patient population worldwide, gallstone-related diseases and interventions will also increase; this includes cholecystectomy for acute cholecystitis, which has a threefold higher risk of CBD stones than elective cholecystectomy. 26,27 Currently, guidelines do not make a distinction in the optimal timing of acute cholecystectomy for cholecystitis when comparing elderly and younger patients.…”