Bile acids for liver-transplanted patients

Alternative therapeutic advantages of catfish bile on atopic dermatitis: protection of T cell-mediated skin disease via antioxidant activities

“…[12] In addition, bile acids have been shown to decrease the degree of allograft rejection after liver transplantation by altering the expression of the major histocompatibility complex class molecules in the bile duct epithelium and central vein endothelium. [13] In other studies UDCA has been found to inhibit apoptosis by preventing cytochrome c release and modulating mitochondrial membrane perturbation. [14,15] In addition, UDCA has been used to treat putatively immunemediated liver diseases, although the mechanism of this action is unknown.…”

“…Although UDCA has been widely used to treat cholestatic liver disease, it has also been used to suppress immune responses [12] . In addition, bile acids have been shown to decrease the degree of allograft rejection after liver transplantation by altering the expression of the major histocompatibility complex class molecules in the bile duct epithelium and central vein endothelium [13] . In other studies UDCA has been found to inhibit apoptosis by preventing cytochrome c release and modulating mitochondrial membrane perturbation [14,15] .…”

Cyclosporine A versus tacrolimus monotherapy. Comparison on bile lipids in the first 3 months after liver transplant in humans

“…HBV patients received standard immunoprophylaxis plus lamivudine 100 mg/day. Ursodeoxycholic acid was not administered in any patients as no clear clinical indication for using it after OLT has been demonstrated [25]. Few other drugs were administered in the early phases after liver transplant in the intensive care unit: none of them had documented choleretic or cholestatic effects and are comparable with those used in previous studies.…”