Bile Acids as Building Blocks of Supramolecular Hosts

Abstract

A review of the use of bile acid-based compounds as building blocks for designing novel supramolecular hosts for molecular recognition is presented. Pharmacological applications and the newest spectroscopic and computational studies of bile acid derivatives are also shortly considered.

Membranolytic Activity of Bile Salts: Influence of Biological Membrane Properties and Composition

“…Various applications with bile salts have been reported [38][39][40][41][42][43]. Taminen and Kolekmainen [44] have recently reviewed the potential of bile acids as building blocks for the formation of supramolecular structures, which have been shown to possess molecular recognition properties. As an example bile acid-porphyrin conjugates are investigated with respect to their saccharide binding capacities [45][46][47].…”

Recent Developments in the Isolation and Synthesis of D‐Homosteroids and Related Compounds

“…Steroidal conjugates and their pharmacological applications have been discussed by Salunke et al 5 and the use of bile acids as building blocks of supramolecular hosts has been surveyed by Tamminen and Kolehmainen. 6 Another possible way to obtain new, useful steroids for medicinal chemical purposes is to modify the original sterane skeleton, for example by the enlargement of ring D. The insertion of one additional carbon atom in ring D may alter the biological properties. 7 For example, the estrogen receptors recognize Dhomoestradiol (1) only poorly; the compound exhibit of three magnitude lower receptor binding affinity, then estradiol.…”

Design and studies of novel polyoxysterol-based porphyrin conjugates

“…They are used as photosensitizers for photodynamic therapy [3], in saccharide sensing [4][5][6][7][8][9], and anion binding [10]. Nearly all studies have been limited so far to bileacid based structures [11][12][13][14], with a few exceptions of porphyrin conjugates of estrogens [15][16][17], androgens [18,19] and cholesterol [20].…”