Recent Developments in the Isolation and Synthesis of D‐Homosteroids and Related Compounds

Wölfling, János

doi:10.1002/chin.200729234

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[55] Other these unique steroidal alkaloids (38)(39)(40)(41)(42)(43)(44)(45)(46) were excreted from various kinds of salamanders and their structure was determined to have been described in an excellent overview. [55] HOIL DERIVED FROM MARINE SOURCES HOIL are widely produced by marine organisms, [9,56] but we have a small series (47-67) of these lipids, many of which show different biological activities. Thus, cytotoxic steroid called swinhoeisterol B (47) with an unprecedented 6/6/5/7 ring system, was isolated from the sponge Theonella swinhoei.…”

Section: Introductionmentioning

confidence: 99%

Highly oxygenated isoprenoid lipids derived from terrestrial and aquatic sources: Origin, structures and biological activities

Vil

Gloriozova

Terent’ev

et al. 2019

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

This mini review is devoted to an interesting group of natural terpenoids called highly oxygenated isoprenoid lipids (HOIL). Their producers are microorganisms, as well as they are found in plants, fungi, animals and marine organisms. The present review consists of three parts. For all three groups of HOIL presented, the chemical structure and the calculated biological activity are given. The first is an overview of HOIL found in nature with a description of some of the pharmacological properties and activity. For the first group of terpenoids, the most characteristic activities are anti‐seborrheic, antineoplastic, and anti‐inflammatory, and they can be used as ovulation inhibitors with a certainty of 85 to 91 percent. In the second part, we present an interesting group of heterocyclic HOIL (or steroidal alkaloids) found in nature with an indication of their possible activity. For the second group of HOIL, the most characteristic activities are: hypolipemic, antifungal, and antineoplastic, and they can be used as lipid metabolism regulators with a confidence of 81 to 89 percent. And in the third group, we represent HOIL derived from marine microorganisms and invertebrates. For the third group of HOIL, the most characteristic activities are: antineoplastic and antipsoriatic and they can be used as cytochrome P450 inhibitors and hepatoprotectants with a confidence of 77 to 93 percent.

show abstract