Bile acids and their receptors in regulation of gut health and diseases

Lin, Sen; Wang, Sutian; Wang, Peng; Tang, Cuiming; Wang, Zhenjiang; Chen, Lian; Luo, Guoqing; Chen, Hong; Liu, Yuntao; Feng, Bin; Wu, De; Burrin, Douglas G.; Fang, Zhengfeng

doi:10.1016/j.plipres.2022.101210

Cited by 34 publications

(37 citation statements)

References 186 publications

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“…Finally, we observed a decrease in the conjugated bile acid, glycochenodeoxycholic acid, in the low-sulfur MD-intervention group versus the control group. Disturbances in bile acid metabolism are associated with IBD, as they play an important role in perpetuating the pro-inflammatory cycle between microbiota and the host [ 35 , 71 , 72 ]. Specifically, fecal-conjugated bile acids are significantly higher in active IBD [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis

Strauss

Haskey

Ramay

et al. 2023

IJMS

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Diet influences the pathogenesis and clinical course of inflammatory bowel disease (IBD). The Mediterranean diet (MD) is linked to reductions in inflammatory biomarkers and alterations in microbial taxa and metabolites associated with health. We aimed to identify features of the gut microbiome that mediate the relationship between the MD and fecal calprotectin (FCP) in ulcerative colitis (UC). Weighted gene co-expression network analysis (WGCNA) was used to identify modules of co-abundant microbial taxa and metabolites correlated with the MD and FCP. The features considered were gut microbial taxa, serum metabolites, dietary components, short-chain fatty acid and bile acid profiles in participants that experienced an increase (n = 13) or decrease in FCP (n = 16) over eight weeks. WGCNA revealed ten modules containing sixteen key features that acted as key mediators between the MD and FCP. Three taxa (Faecalibacterium prausnitzii, Dorea longicatena, Roseburia inulinivorans) and a cluster of four metabolites (benzyl alcohol, 3-hydroxyphenylacetate, 3-4-hydroxyphenylacetate and phenylacetate) demonstrated a strong mediating effect (ACME: −1.23, p = 0.004). This study identified a novel association between diet, inflammation and the gut microbiome, providing new insights into the underlying mechanisms of how a MD may influence IBD. See clinicaltrials.gov (NCT04474561).

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Section: Discussionmentioning

confidence: 99%

Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis

Strauss

Haskey

Ramay

et al. 2023

IJMS

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“…As the liver is the primary site of BA metabolism, we measured the relative mRNA abundance related to BA synthesis and transport in the liver. After ZEN treatment, the relative mRNA abundance of FXR, a key regulator of BA metabolism, 4 was lower (P < 0.05) in female and male rats compared to that in the rats of the control group. The relative mRNA abundance of cholesterol 7α-hydroxylase (CYP7A1), a rate-limiting enzyme required for BAs synthesis, 4 was upregulated (P < 0.05) in the ZEN-F group compared to that in the CON-F group (Figure 2A).…”

Section: Zen Altered the Expression Levels Of Key Genes And Proteins ...mentioning

confidence: 91%

“…After ZEN treatment, the relative mRNA abundance of FXR, a key regulator of BA metabolism, 4 was lower (P < 0.05) in female and male rats compared to that in the rats of the control group. The relative mRNA abundance of cholesterol 7α-hydroxylase (CYP7A1), a rate-limiting enzyme required for BAs synthesis, 4 was upregulated (P < 0.05) in the ZEN-F group compared to that in the CON-F group (Figure 2A). The average abundance of CYP7A1 mRNA was higher in the ZEN-M group than in the CON-M group, although the difference was not significant (Figure 2A).…”

Section: Zen Altered the Expression Levels Of Key Genes And Proteins ...mentioning

confidence: 91%

Zearalenone Decreases Food Intake by Disrupting the Gut–Liver–Hypothalamus Axis Signaling via Bile Acids

Yuan,

Ma,

et al. 2024

J. Agric. Food Chem.

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Zearalenone (ZEN) is a mycotoxin that is harmful to humans and animals. In this study, female and male rats were exposed to ZEN, and the results showed that ZEN reduced the farnesoid X receptor (FXR) expression levels in the liver and disrupted the enterohepatic circulation of bile acids (BAs). A decrease in food intake induced by ZEN was negatively correlated with an increase in the level of total BAs. BA-targeted metabolomics revealed that ZEN increased glycochenodeoxycholic acid levels and decreased the ratio of conjugated BAs to unconjugated BAs, which further increased the hypothalamic FXR expression levels. Preventing the increase in total BA levels induced by ZEN via Lactobacillus rhamnosus GG intervention restored the appetite. In conclusion, ZEN disrupted the enterohepatic circulation of BAs to decrease the level of food intake. This study reveals a possible mechanism by which ZEN affects food intake and provides a new approach to decrease the toxic effects of ZEN.

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“…These receptors are expressed in various organs, including the brain [ 53 , 54 , 55 , 56 , 57 , 58 ]. Therefore, BAs play diverse physiological roles through the affect they have on these various receptors [ 7 , 59 , 60 ].…”

Section: Bas As Regulatory Modulatorsmentioning

confidence: 99%

Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases

Kiriyama

Nochi

2023

Genes

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Bile acids (BAs) are amphiphilic steroidal molecules generated from cholesterol in the liver and facilitate the digestion and absorption of fat-soluble substances in the gut. Some BAs in the intestine are modified by the gut microbiota. Because BAs are modified in a variety of ways by different types of bacteria present in the gut microbiota, changes in the gut microbiota can affect the metabolism of BAs in the host. Although most BAs absorbed from the gut are transferred to the liver, some are transferred to the systemic circulation. Furthermore, BAs have also been detected in the brain and are thought to migrate into the brain through the systemic circulation. Although BAs are known to affect a variety of physiological functions by acting as ligands for various nuclear and cell-surface receptors, BAs have also been found to act on mitochondria and autophagy in the cell. This review focuses on the BAs modified by the gut microbiota and their roles in intracellular organelles and neurodegenerative diseases.

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Bile acids and their receptors in regulation of gut health and diseases

Cited by 34 publications

References 186 publications

Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis

Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis

Zearalenone Decreases Food Intake by Disrupting the Gut–Liver–Hypothalamus Axis Signaling via Bile Acids

Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases

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