Bildung und Abbau biogener Amine

Werle, E.

doi:10.1002/ange.19430562102

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…Sheep were fed with histamine-rich diet in a quantity which could be observed in some plants [53]. In these animals the urinary excretion of free histamine was increased 22-fold by a treatment with aminoguanidine.…”

Section: Tablementioning

confidence: 99%

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

et al. 1975

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From all mammals investigated so far only in rabbits diamine oxidase could not be detected in any tissue except the gut. Thus this species was chosen for studying the physiological and pathophysiological function of this enzyme in the gastrointestinal tract. By gel filtration on Sephadex G 50 and G 200 the enzyme was purified 100-fold, separated from a soluble monoamine oxidase, and the properties of the two enzymes were determined. Diamine oxidase from rabbit small intestine deaminated putrecine (Km = 1.3 times 10(-4) M, pH-optimum 6.4-6.9) and histamine (Km = 8 times 10(-5) M, pH-optimum 7.5), but not serotonin, and was inhibited by aminoguanidine, but not by pargyline. Soluble monoamine oxidase from rabbit small intestine catabolized serotonin (Km = 1.8 times 10(-4) M, pH-optimum 8.8) but not putrescine and histamine, and was inhibited by pargyline, but not by aminoguanidine. Based on its properties in vitro intestinal diamine oxidase could inactivate the vasoactive biogenic amine histamine in vivo. To confirm this hypothesis, in rabbits the small intestine was damaged severely by inducing total intestinal ischemia, which occurs as mesenteric infarction also in human subjects and is accompanied by histamine release. Treatment with aminoguanidine and ischemia killed the animals 3-times faster than ischemia alone, which supported our hypothesis on a protective role of intestinal diamine oxidase against histamine.

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Section: Tablementioning

confidence: 99%

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

et al. 1975

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“…Histamine is a widely distributed biogenic amine which can be found in man and animals, and also in plants [1] and bacteria [2], In the human body, it is present in various tissues including blood vessels, the heart, the nervous system and extravascular smooth muscles, with the highest con centrations in the lungs, the skin and the gastrointestinal tract [3], Histamine is generated from the amino acid precursor histidine by the action of histidine decarboxylase. The in activation of histamine by N-methyltransferase and mono amino oxidase leads to the formation of the metabolites N-methylhistaminc (MH) and N-methylimidazole acetic acid (MIAA) [4],…”

Section: Introductionmentioning

confidence: 99%

Measurement and Characterization of Histamine and Methylhistamine in Human Urine under Histamine-Rich and Histamine-Poor Diets

Hermann¹,

Hertenberger²,

Ring³

1993

Int Arch Allergy Immunol

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A radioimmunoassay for histamine was used to measure histamine and 1-methylhistamine (MH) in human urine samples. The detection limit of this assay was 2 ng/ml for histamine and 0.5 ng/ml for MH. Cation exchange high performance liquid chromatography (HPLC) on a Bio-Gel TSK SP-5 PW column with gradient elution was capable of separating histamine from its precursor L-histidine and its metabolites MH and 1-methylimidazole acetic acid (MIAA). The concentration of MH-immunoreactive material in healthy volunteers with no dietary restrictions was 202 ± 92 μg/24 h (mean ± SD; n = 14). The excretion of MH-like material, expressed as micrograms of MH per 24 h, was not significantly different before or after the intake of histamine-rich food: 217 ± 88 vs. 276 ± 135 μg/24 h (n = 10). However, in urine samples collected in individual fractions, the levels of MH immunoreactivity were significantly increased after a histamine-rich meal in comparison to the corresponding fractions which were taken a day earlier at the same time intervals after a histamine-low diet (p < 0.03). HPLC characterization of MH immunoreactivity revealed the presence of histamine, MH and a compound with the same retention time as MIAA. The ratio of histamine, MH and MIAA in controls without dietary restrictions, as determined by HPLC analysis, was 50 ± 6, 47 ± 5 and 3 ± 1%, respectively. After a histamine-rich meal the ratio was 97 ± 2% for histamine, 1% for MH and 2 ± 1% for MIAA.

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Mitosegifte und cancerogene Faktoren als Antibiotica

Lettré

1948

Z Krebs-forsch

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Bildung und Abbau biogener Amine

Cited by 6 publications

References 76 publications

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

Measurement and Characterization of Histamine and Methylhistamine in Human Urine under Histamine-Rich and Histamine-Poor Diets

Mitosegifte und cancerogene Faktoren als Antibiotica

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