Bilberry: Chemical Profiling, <i>in Vitro</i> and <i>in Vivo</i> Antioxidant Activity and Nephroprotective Effect against Gentamicin Toxicity in Rats

Veljković, Milica; Pavlović, Dragana; Stojiljković, Nenad; Ilić, Sonja; Jovanović, Ivan; Ulrih, Nataša Poklar; Rakić, Violeta; Veličković, Ljubinka Janković; Sokolović, Dušan

doi:10.1002/ptr.5738

Cited by 20 publications

(20 citation statements)

References 24 publications

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“…Anthocyanin is a soluble pigment which is consisted naturally and belongs to flavylium cation structure [ 13 ]. Thanks to anthocyanins, bilberries have commonly biological effects such as anti-inflammatory, anticarcinogenic, antioxidant, and remaining normal physiological functions [ 14 , 18 ]. Antioxidant effect of bilberry was obtained by Bao et al.…”

Section: Discussionmentioning

confidence: 99%

Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study

Eren

Aydın²,

Tümkaya

et al. 2018

Renal Failure

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Purpose: This study investigated the antioxidant effects of whortleberry against cisplatin-induced nephrotoxicity in rats.Material and methods: This study included 48 female Sprague–Dawley rats weighing 263.68 ± 8.29 g. The rats were divided into the following six groups, with eight rats in each group: control, ethanol control, whortleberry control, cisplatin control, 16 mg/kg cisplatin +100 mg/kg whortleberry, and 16 mg/kg cisplatin +200 mg/kg whortleberry groups. Biochemical analysis was performed by measuring total oxidant status and total antioxidant status, histopathological analysis was performed by calculating proximal and distal tubule areas (μm2), and immunohistochemical analysis was performed by determining anti-Caspase-3 immunostaining. Differences among the groups were examined using one-way analysis of variance, and p < .05 was considered statistically significant.Results: Cisplatin treatment decreased the total antioxidant status and increased the total oxidant status and Caspase-3 level. Moreover, it resulted in the dilatation, vacuolization and loss of tubular epithelial cells; and glomerular degeneration and edema in the kidney tissues (p < .05). Treatment with 100 and 200 mg whortleberries increased the total antioxidant status; decreased the total oxidant status and Caspase-3 level and ameliorated distal and proximal tubule degeneration, glomerular degeneration and edema in the kidney tissues (p < .05).Conclusions: Our results indicate that the antioxidant effects of the whortleberry decrease cisplatin-associated nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study

Eren

Aydın²,

Tümkaya

et al. 2018

Renal Failure

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“…Gentamicin-induced nephrotoxicity is associated with an excessive formation of ROS and RNS [45]. Veljkovic et al [46] demonstrated that consumption of bilberry extract (100 mg/kg/day) for 15 days protected rats against gentamicin-induced nephrotoxicity by maintaining the activity of antioxidant enzymes. Likewise, consumption of edible berry mixture OptiBerry (20 mg/kg/week) (wild blueberry, bilberry, cranberry, elderberry, raspberry seeds and strawberry) for eight weeks significantly prevented hyperbaric oxygen-induced reduced glutathione (GSH) oxidation in the lung and liver of vitamin E-deficient rats [23].…”

Section: Antioxidant Effectmentioning

confidence: 99%

Effects of Bilberry Supplementation on Metabolic and Cardiovascular Disease Risk

Chan

Tomlinson

2020

Molecules

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Metabolic syndrome is a cluster of interrelated conditions that is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Oxidative stress may impair normal physiological functions, leading to various illnesses. T2DM is considered to be associated with increased oxidative stress, inflammation, and dyslipidemia, which may play a significant role in the development of cardiovascular complications, cancer and vision loss through cataracts and retinopathy. While conventional therapies are a cornerstone for the management of the major risk factors of metabolic syndrome, increasing antioxidant defense by increasing intake of antioxidant-rich foods may improve long term prospects in CVD, obesity and T2DM. Bilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which give berries their red/purple/blue coloration. Anthocyanins are powerful antioxidants and are reported to play an important role in the prevention of metabolic disease and CVD as well as cancer and other conditions. This review focuses on the potential effects of bilberry supplementation on metabolic and cardiovascular risk factors. Although there is evidence to support the use of bilberry supplementation as part of a healthy diet, the potential benefits from the use of bilberry supplementation in patients with T2DM or CVD needs to be clarified in large clinical trials.

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“…So that the possibility of nephrotoxicity becomes a risk in the treatment using gentamicin. 2 Sterculia genus contains phenol compounds, flavonoids and their derivatives, terpenoids which are mostly as triterpenoids, coumarin, alkaloids and other compounds including phenolic acids, phenyl propanoids, fatty acids, sugars and some steroids. 3 Based on literature studies it is known that the primary production of secondary metabolites in the genus Sterculia is phenols and flavonoids.…”

Section: Introductionmentioning

confidence: 99%

The Nephroprotective And Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves

Prastiwi¹,

Dewanti²,

Fadliani³

et al. 2020

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Background: Sterculia has an antioxidant activity. The Sterculia genus has phenols and flavonoids content, and this chemical content may be have an nephroprotective activity. Objective: The study was to investigate the in vitro study of antioxidant activity with DPPH and FRAP study and nephroprotective activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves extract. Materials and Methods: The leaves was extracted using ethanol. This extract was determined for antioxidant activity by in vitro study with DPPH and FRAP methods, determined the content of total phenols, total flavonoids, and also identification of chemical content. Nephrotoxicity study done by induced gentamycin. The groups divided 6 group, consist: negative control, positive control, normal control, and the extract with dose 50 mg/kg, 100 mg/kg, and 200 mg/ kg. The parameter for nephroprotective activity was tubular necrosis, the presence of tubules casts and glomerular damage, creatinine serum, and urea. Results: The ethanol extract has IC 50 162.34 µg/ml for DPPH scavenging activity and 18.65 ± 3.53 FeEAC (Mol/g) for FRAP. The secondary metabolite presence flavonoids, tannins, terpenes, alkaloids, and glycosides. The total phenols 462.36 ± 9.23 mg GAE/gr, total flavonoids content 59.44 ± 0.11 mg QE/gr extract. All the dose have an nephroprotective activity, but the best dose was 50 mg/kg. Conclusion: The ethanol extract of Sterculia rubiginosa showed antioxidant activity and nephroprotective activity.

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Bilberry: Chemical Profiling, in Vitro and in Vivo Antioxidant Activity and Nephroprotective Effect against Gentamicin Toxicity in Rats

Cited by 20 publications

References 24 publications

Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study

Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study

Effects of Bilberry Supplementation on Metabolic and Cardiovascular Disease Risk

The Nephroprotective And Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves

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