Bilateral XEN Gel Stent Implantation in Juvenile-Onset Open-Angle Glaucoma

Klug, Emma; Valle, David Solá-Del

doi:10.1159/000508391

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Khouri et al [25] reported the surgical success of the Kahook Dual Blade® in a 14-year-old male patient with JOAG. Klug and Solá-Del Valle [26] reported successful bilateral XEN gel stent implantation in a 48-year-old woman with JOAG. In our cohort, six eyes underwent GATT, and one eye underwent a deep sclerotomy and an external suture trabeculotomy.…”

Section: Discussionmentioning

confidence: 99%

Surgical approaches to juvenile open-angle glaucoma

2024

Eur Eye Res

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To present the surgical options and surgical outcomes of juvenile open-angle glaucoma (JOAG). Methods: A retrospective review of the case series with JOAG that had undergone surgical treatment was undertaken. Surgical techniques, patient characteristics, and surgical outcomes were analyzed. Results: Thirteen eyes from eight patients with the diagnosis of JOAG were included in the study. The mean age was 26.77 ± 9.83 years. Five (62.5%) of the patients were male. The distribution of the operations was as follows: deep sclerectomy and external suture trabeculotomy in one eye (8%); Ahmed glaucoma valve implantation in one eye (8%); trabeculectomy with antimetabolite augmentation in five eyes (38%); and gonioscopy-assisted transluminal trabeculotomy (GATT) in six eyes (46%). The preoperative mean intraocular pressure (IOP) was 27.62 ± 7.17 mmHg, which decreased to 17.62 ± 13.06 mmHg at the last follow-up visit (36.21% decrease, P = 0.023, Wilcoxon rank test). IOP control was achieved without any additional surgical intervention in 10 (76.9%) eyes over the mean of 15.62 ± 12.17 months of the follow-up period. Further glaucoma surgery was required in three eyes, of which two had undergone GATT and one had undergone trabeculectomy as the primary surgery. Conclusion:The surgical treatment of JOAG results in IOP reduction, and more than one surgery may be required in some cases.

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Section: Discussionmentioning

confidence: 99%

Surgical approaches to juvenile open-angle glaucoma

2024

Eur Eye Res

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“…Recent case reports have reported on the success of less commonly used MIGS procedures in JOAG patients. Khouri et al [29] reported success using the Kahook Dual Blade in a 14-year-old male with JOAG and Klug and Sola ´-Del Valle [30] reported successful bilateral XEN Gel Stent implants in a 48-year-old female with JOAG.…”

Section: Salimi Et Al [25mentioning

confidence: 99%

Juvenile open angle glaucoma: current diagnosis and management

Ciociola¹,

Klifto

2021

Current Opinion in Ophthalmology

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Purpose of reviewThe aim of this article is to summarize up-to-date research on the diagnosis and management of juvenile open-angle glaucoma (JOAG). Recent findingsJOAG can be subclassified into four clinical phenotypes, and faster myopic shift is a risk factor for disease progression. Vessel density is associated with structural damage and worsening visual acuity in JOAG and can be monitored with optical coherence tomography angiography. Genetic studies have revealed molecular causes of JOAG including variants in CPAMD8, MYOC, and CYP1B1. Tube shunt surgeries as well as gonioscopy-assisted transluminal trabeculotomy have been shown to be successful in JOAG. SummaryAlthough genetic advances may improve future screening, intraocular pressure monitoring and fundoscopic exam remain the current mainstay of diagnosis. Medical treatment alone for JOAG is typically insufficient with patients requiring surgical management. Selective laser trabeculoplasty may delay or decrease the need for surgery. Trabeculectomy has traditionally been shown to be effective in JOAG, but tube shunt surgery and microinvasive glaucoma surgery are effective alternatives.

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