Juvenile-onset open-angle glaucoma – A clinical and genetic update

Selvan, Harathy; Gupta, Shikha; Wiggs, Janey L.; Gupta, Viney

doi:10.1016/j.survophthal.2021.09.001

Cited by 25 publications

(24 citation statements)

References 192 publications

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“…Given the damaging retinal circulation with glaucoma progression ( 19 ), the correlation between the extent of microcirculation improvement and IOP reduction was inconsistent among studies. In comparison, ocular hypertension (OHT) patients present no signs of glaucomatous defects but suffer the risk of developing and progressing into primary open-angle glaucoma (POAG) with long-term IOP elevation ( 20 – 22 ). Previous studies revealed that the IOP reduction for OHT showed little impact on the ophthalmic artery ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

Chen

Hong

et al. 2021

Front. Med.

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Purpose: To investigate the relationship between retinal microvasculature changes and intraocular pressure (IOP) for ocular hypertension (OHT) patients and further assess the factors associated with retinal microcirculation changes.Methods: This was a single-center prospective study designed for OHT patients, which consisted of two visits. After collecting baseline data of those who met the eligibility criteria, these patients were treated with latanoprost 0.005% ophthalmic solution for 4 weeks. Peripapillary vessel density (VD) of radial peripapillary capillaries (RPC) layer, macular VD in both superficial and deep layers, and foveal avascular zone (FAZ) area were measured by optical coherence tomography angiography (OCTA) before and after the treatment. We compared the changes in IOP and VD among the two visits by paired-sample t-test. Bonferroni correction was applied. Factors associated with VD changes were analyzed by linear regression analysis.Results: Thirty-four eyes of thirty-four patients were included. The mean IOP decreased by 6.5 ± 2.2 mmHg (p < 0.001). The peripapillary RPC VD increased significantly from 51.8 ± 2.5 to 53.0 ± 3.1% (Adjusted-p = 0.012). We found no significant difference in detailed sectors of the peripapillary region after correction. In the macular area, both the superficial and deep layers in foveal (superficial: 0.2 ± 1.9%, p = 0.523; deep: 0.0 ± 2.3%, p = 0.969) and parafoveal (superficial: 0.3 ± 3.0%, p = 0.565; deep: 0.5 ± 3.1%, p = 0.423) VD remained unchanged. The decrease of the mean FAZ area was insignificant (p = 0.295). The percentage of IOP reduction (β = 0.330, p = 0.031) and the baseline RNFL thickness (β = 0.450, p = 0.004) significantly correlated with the percentage of peripapillary RPC VD improvement in the multivariate linear regression analysis.Conclusion: The peripapillary VD in OHT patients increased after the reduction of IOP. The mild change of IOP did not alter the microcirculation in the macula. In addition, the percentage of IOP change and the baseline RNFL thickness were independent factors for the peripapillary RPC VD improvement.

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Section: Introductionmentioning

confidence: 99%

Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

Chen

Hong

et al. 2021

Front. Med.

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“…8 It is characterized by high intraocular pressures which damage the optic nerve and cause deep cupping. 9 Our patient was diagnosed in her late twenties and presented to us late in the course of this disease, with almost complete vision loss and total cupping. She also presented with very high IOPs, as is characteristic of JOAG patients.…”

Section: Discussionmentioning

confidence: 88%

“…JOAG can cause significant visual disability and requires careful monitoring and management to preserve vision. 9 This is of particular concern in Rett syndrome. Because these patients lose verbal language, their means of communication has been noted to be primarily through eye gaze and eye pointing.…”

Section: Discussionmentioning

confidence: 99%

A case of JOAG in a patient with Rett syndrome

Shaheen¹,

Fleischman²

2023

American Journal of Ophthalmology Case Reports

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“…The TM in glaucomatous eyes is characterized by decreased elasticity and increased stiffness as a result of aging [ 18 , 19 ]. Myopia is the common feature of juvenile-onset glaucoma [ 20 ]. Thus, traction on the pectinate ligament or elastic TM tissue exerted by a relatively dull device (i.e., microhooks) may explain the bleeding from the angle and blood clot formation in young patients with glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Postoperative Hyphemas between Microhook Ab Interno Trabeculotomy and iStent Using a New Hyphema Scoring System

Ishida

Ichioka

Takayanagi

et al. 2021

JCM

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We have been using our in-house scoring system of hyphemas, i.e., Shimane University RLC postoperative hyphema scoring system (SU-RLC), which we designed to classify postoperative hyphema. SU-RLC classifies the severities of hyphemas based on three factors, i.e., red blood cells (RBCs) (R) 0–3, layer formation (L) 0–3, and clot (C) 0–1, by slit-lamp observation. To test the clinical usefulness of the SU-RLC for quantifying the postoperative hyphema severity, the SU-RLC scores were compared between eyes that underwent different minimally invasive glaucoma surgery (MIGS) procedures, i.e., Tanito microhook ab interno trabeculotomy and cataract extraction (TMH-CE) (n = 64 eyes of 64 subjects; mean age ± standard deviation, 72.4 ± 8.1 years) and iStent-CE (n = 21 eyes of 21 subjects; 76.1 ± 10.6 years). Compared to the iStent-CE, higher hyphema scores with the TMH-CE were found for the R scores on postoperative days 1, 2, and 3; for the L score on postoperative day 1; and for the C score on postoperative day 2. The sums of the R, L, and C scores (RLC) on postoperative day 1 were 3.2 ± 1.1 with the TMH-CE and 1.1 ± 1.3 with the iStent-CE; the scores reached almost 0 by 2 weeks in both groups. Significant differences in the RLC scores between the surgical groups were found on postoperative days 1, 2, and 3. Multivariate analyses showed that the TMH-CE rather than iStent-CE was associated with higher R, C, and RLC scores; anticoagulant/antiplatelet use was associated with higher R score; and myopia was associated with a higher C score. In the TMH-CE group, myopia was associated with a higher C score. In the iStent-CE group, anticoagulant/antiplatelet use was associated with higher R and RLC scores; and higher postoperative 1-day intraocular pressure was associated with a higher C score. The SU-RLC successfully detected the difference in hyphema severity between different MIGS procedures; thus, we concluded that our classification system may be feasible to evaluate hyphemas after glaucoma surgery.

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Juvenile-onset open-angle glaucoma – A clinical and genetic update

Cited by 25 publications

References 192 publications

Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

A case of JOAG in a patient with Rett syndrome

Comparison of Postoperative Hyphemas between Microhook Ab Interno Trabeculotomy and iStent Using a New Hyphema Scoring System

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