Bilateral vitreous hemorrhages in an infant with low fibrinogen levels

Marshman, Wendy E.; Adams, Gillian; Ohri, R

doi:10.1016/s1091-8531(99)70013-3

Cited by 23 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…76 Bleeding disorders have only rarely been reported to be the cause of isolated retinal hemorrhages in neonates. 80 Multiple fractures of differing ages (especially posterior rib fractures in infants with subdural hematoma) or inconsistencies between the reported mechanism and the pattern or extent of injuries suggest nonaccidental trauma, especially when there is a delay in seeking medical attention. 81 Conversely, consideration should be given to RBDs in children from consanguineous parents or with a personal or family history of bleeding, particularly in the absence of other features suggesting nonaccidental trauma.…”

Section: State-of-the-art Review Articlementioning

confidence: 99%

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Acharya

2013

Pediatrics

View full text Add to dashboard Cite

Bleeding symptoms are common in healthy children but occasionally may indicate an underlying congenital or acquired bleeding diathesis. The rare bleeding disorders (RBDs) comprise inherited deficiencies of coagulation factors I (congenital fibrinogen deficiencies), II, V, VII, X, XI, and XIII and combined factor deficiencies, most notably of factors V and VIII and of vitamin K-dependent factors. These disorders often manifest during childhood and may present with recurrent or even serious or life-threatening bleeding episodes, particularly during the neonatal period. Accordingly, primary care and other nonhematologist pediatric providers should be familiar with the clinical presentation and initial evaluation of these rare disorders. Bleeding manifestations generally vary within the same RBD and may be indistinguishable from 1 RBD to another or from other more common bleeding disorders. Serious bleeding events such as intracranial hemorrhage may be heralded by less serious bleeding symptoms. The results of initial coagulation studies, especially prothrombin time and activated partial thromboplastin time, are often helpful in narrowing down the potential factor deficiency, with factor XIII deficiency being an exception. Consultation with a hematologist is advised to facilitate accurate diagnosis and to ensure proper management and follow-up. The approach to bleeding episodes and invasive procedures is individualized and depends on the severity, frequency, and, in the case of procedures, likelihood of bleeding. Prophylaxis may be appropriate in children with recurrent serious bleeding and specifically after life-threatening bleeding episodes. When available, specific purified plasma-derived or recombinant factor concentrates, rather than fresh frozen plasma or cryoprecipitate, are the treatment of choice. Pediatrics 2013;132:882-892

show abstract

Section: State-of-the-art Review Articlementioning

confidence: 99%

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Acharya

2013

Pediatrics

View full text Add to dashboard Cite

show abstract

“…There are substantial numbers of cases reporting RH in infants due to apparently innocent causes, or in the context of a variety of medical disease such as spinal arteriovenous malformation [19], fibromuscular dysplasia [20], osteogenesis imperfecta type I [36], blood dyscrasias [76], and Coats' disease [5]. Although some of these may be associated with minor accidental trauma, stigmata of the underlying disorder allow its recognition usually rather quickly, absolving the physician from the need for further inquiry for suspected child abuse [113].…”

Section: Differential Diagnosismentioning

confidence: 99%

Ocular pathology in shaken baby syndrome and other forms of infantile non-accidental head injury

2008

View full text Add to dashboard Cite

Retinal and optic nerve sheath hemorrhages are an essential part of the various forms of inflicted neurotrauma in infants, especially in its most common variant, the shaken baby syndrome (SBS). Clinically, ophthalmologists play an important part for the diagnosis and further management of patients with SBS. For the forensic pathologist, a thorough understanding of the basic principles behind the morphological phenomena commonly encountered in the orbita is required. This review summarizes the present knowledge of ocular pathology in inflicted infantile neurotrauma, focusing strongly on SBS. Furthermore, a review of the most recent literature on the subject is given.

show abstract

“…Our case is similar to a previously reported case, presenting as spontaneous intraocular hemorrhage with normal prothrombin time and activated partial thromboplastin time and reduced fibrinogen level. 8 However, the possibility of a spontaneous bilateral subhyaloid hemorrhage secondary to Terson syndrome that could be secondary to the hypofibrinoginemia could not be ruled out in the absence of a neuroimaging test performed on this patient. …”

Section: Discussionmentioning

confidence: 84%