Bilateral uveal metastasis of a subcutaneous fibrosarcoma in a cat

Abstract

A 6-year-old neutered male domestic short-haired cat was presented to the Comparative Ophthalmology service at Michigan State University with a 3-week history of decreased appetite and redness of the left eye. The left forelimb had been removed 15 months previously because of the presence of a subcutaneous fibrosarcoma. In the left globe, a large iridal mass was associated with increased intraocular pressure and retinal detachment. A smaller mass involving the right iris was also present. Imaging revealed a 2-cm mass in the left caudodorsal lung lobe, and abdominal ultrasound showed multifocal bilateral renal masses. Aspirates of these masses were nondiagnostic. The left globe was removed for palliative reasons, and histopathology showed that fibrosarcoma was infiltrating the iris, choroid, and optic nerve. Despite systemic chemotherapy with doxorubicin, the animal died 4 months after initial presentation. Histopathology confirmed highly angioinvasive metastatic fibrosarcoma also in the right uveal tract, the lungs, and both kidneys.

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

“…The eyes are considered to be uncommon metastatic sites in dogs and cats 1‐6 ; however, other studies have reported cases with an ocular involvement of metastatic neoplastic diseases 5,7‐12 . Furthermore, as in humans, metastases to the eyes occur mostly via hematogenous spread, usually affecting the uveal tract 1,2,5,10,13 …”

Metastatic intraocular hemangiopericytoma in a dog

“…Lymphoma is the most common of those tumors which have been noted to spread to the eye (Hendrix, 2013). Less commonly documented intraocular metastatic neoplasms include melanoma, hemangiosarcoma, malignant histiocytosis, adenocarcinoma, osteosarcoma, transitional cell carcinoma, and others (Szymanski, 1972;Schmidt, 1981;Render et al, 1982;Szymanski et al, 1984;Habin and Elsa, 1995;Esson et al, 2007;Naranjo et al, 2007;Mowat et al, 2012). Patients with metastatic ocular neoplasia may present with systemic signs attributable to the disease or may only have observable ophthalmic signs.…”