Bilateral synchronous occurrence of three different histological types of renal tumor: a case report

Radopoulos, D.; Tahmatzopoulos, Anastasios; Kalinderis, Nikolaos; Dimitriadis, Georgios

doi:10.1186/1752-1947-3-6798

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…Both types of tumors express differentiation to intercalated cells of the collecting duct system [33] and some authors consider the group oncocytoma/CRCC as a spectrum from benign (oncocytomas) to malignant neoplasm (CRCC) [5]. Both types of neoplasms and mixed forms may be found in oncocytomasis and Birt-Hogg-Dubbe syndrome [4,5,34]. Morphologic and morphogenetic hybrid variants of these tumors are currently being reported [35][36][37][38], most of them with a very favorable prognosis [6,39].…”

Section: Discussionmentioning

confidence: 95%

Mitochondria with Tubulovesicular Cristae in Renal Oncocytomas

Bárcena

Martínez

Ortega

et al. 2010

Ultrastructural Pathology

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Renal oncocytoma and chromophobe renal cell carcinoma (CRCC) are closely related tumors. They are considered the extremes of a spectrum with several variants. Ultrastructural examination of the mitochondria is a helpful procedure in the diagnosis of these neoplasms. Renal oncocytomas show mitochondria with piled lamellar cristae, and CRCC exhibited mitochondria with tubulovesicular cristae. In a series of 23 histologically diagnosed renal oncocytomas examined by electron microscopy, the authors found 5 tumors exhibiting more cells with mitochondria showing tubulovesicular cristae. The authors believe these 5 cases present a submicroscopic appearance intermediate between renal oncocytoma and CRCC, although with benign clinical behavior.

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Section: Discussionmentioning

confidence: 95%

Mitochondria with Tubulovesicular Cristae in Renal Oncocytomas

Bárcena

Martínez

Ortega

et al. 2010

Ultrastructural Pathology

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“…Mukai et al[ 13 ] reported “Synchronous bilateral chromophobe renal cell carcinoma: A case report” in 2009. Radopoulos et al[ 14 ] reported a case of a 57-year-old male patient with two bilateral synchronous chromophobe RCCs accompanied by an oncocytoma and an angiomyolipoma. The patient was treated with open partial nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma accompanied by a clear cell carcinoma and a cyst: A case report

Yang

Zhao

et al. 2020

WJCC

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BACKGROUND Renal cell carcinomas are usually unilateral. However, they are bilateral in 2% to 4% of sporadic cases and is considerably more common in familial cases. Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma (CHRCC) with different subtypes is rare. CASE SUMMARY In this case report, we describe a case of synchronous bilateral CHRCC with two histological variants, accompanied by a clear cell carcinoma and a cyst in a 50-year-old male. The patient underwent retroperitoneal laparoscopic bilateral nephron-sparing surgery and there was no serious postoperative renal dysfunction. CONCLUSION We report a rare case of synchronous bilateral CHRCC with two histological variants associated with a clear cell carcinoma and a cyst.

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“…The incidence of this condition has been on the rise due to the increased utilization of ultrasonography and CT scans for evaluating patients with varying clinical presentations [ 4 , 5 ]. Bilateral tumors, either synchronous or asynchronous, have been reported in 2-4% of sporadic cases [ 6 ]. The ccRCC is responsible for 60-75% of unilateral RCC cases [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Combined Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Case Report

Meliti,

Alardati,

Khayat

et al. 2024

Cureus

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Renal cell carcinoma (RCC) is a diverse array of cancers arising from renal tubular epithelial cells. RCC presenting with distinct morphological subtypes, such as the simultaneous presence of chromophobe RCC (chRCC) and clear cell RCC (ccRCC) lesions within the same kidney, is rare. We present the case of a 79-yearold female with a history of breast cancer who presented to our facility with right flank pain. Further investigations using CT of the abdomen and pelvis revealed a Bosniak type 4 cyst with a mural nodule in the right kidney. Furthermore, another well-defined, solid lesion measuring 2.8 × 2.6 cm was observed in the same area. The patient underwent a right radical nephrectomy. The macroscopic examination of the kidney revealed the presence of three cysts, with the largest measuring up to 7.5 cm. Moreover, a distinctly demarcated, golden-yellow, solid mass was discerned in the superior pole of the kidney. The mass showed a heterogeneous cut surface with solid and cystic components, measuring 2.8 × 2.6 × 2.0 cm. A less extensive but well-defined, uniform tan mass was also identified within the wall of the largest cyst, which measured 1.2 × 1.0 × 0.7 cm. At this point, the diagnosis of ccRCC and chRCC was established.

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Bilateral synchronous occurrence of three different histological types of renal tumor: a case report

Cited by 7 publications

References 9 publications

Mitochondria with Tubulovesicular Cristae in Renal Oncocytomas

Mitochondria with Tubulovesicular Cristae in Renal Oncocytomas

Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma accompanied by a clear cell carcinoma and a cyst: A case report

Combined Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Case Report

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