Bilateral synchronous breast carcinomas followed by a metastasis to the gallbladder: a case report

Zagouri, Flora; Sergentanis, Theodoros N.; Koulocheri, Dimitra; Nonni, Afroditi; Bousiotou, Aggeliki; Domeyer, Philip; Michalopoulos, Nikolaos V.; Dardamanis, Dimitrios; Konstadoulakis, Manousos M.; Zografos, George

doi:10.1186/1477-7819-5-101

Cited by 25 publications

(20 citation statements)

References 10 publications

(11 reference statements)

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“…Bilateral breast cancer has been reported from countries as diverse as USA, Italy, Greece, India, and Japan [1][2][3][4][5]. Therefore, the present paper documents the parameters discovered among the Igbo Ethnic Group, which is domiciled in South-Eastern Nigeria.…”

Section: Introductionmentioning

confidence: 90%

Bilateral breast cancer in a Nigerian community

Onuigbo¹

2017

Obstet Gynecol Rep

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In different parts of the world, there is published evidence regarding the bilateral synchronous occurrence of breast cancer. Therefore, this paper considers the parameters met among the Igbo Ethnic Group, who are domiciled mostly in South-Eastern Nigeria. The median age was 42 years. In the series of 6 cases, all but one was synchronous. The histological type tended to be the same on both sides, including one woman in whom three distinct types occurred bilaterally. Ductal carcinoma was the commonest type while the odd inflammatory carcinoma was prominent.

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Section: Introductionmentioning

confidence: 90%

Bilateral breast cancer in a Nigerian community

Onuigbo¹

2017

Obstet Gynecol Rep

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“…Most of the rare reported cases of MBC with gallbladder metastasis were associated with lobular histology. [5][6][7] The case is exceptional for being associated with a ductal histology as suggested by the positive e-cadherin staining on the primary and metastatic specimens. Perhaps, this confirms the aggressive nature of IBC irrespective of the histology and tumor markers.…”

Section: Case Reportmentioning

confidence: 99%

“…4 Gallbladder metastasis from breast cancer is very rare, and only 15-20 cases have been reported in the literature. [5][6][7] Most of those cases have been associated particularly with a lobular histology. We report an additional rare case of MBC to the gallbladder, but with a ductal histology.…”

mentioning

confidence: 99%

Inflammatory metastatic breast cancer with gallbladder metastasis: an incidental finding

Ebrahim

Graham

Rice³

et al. 2015

J Community Support Oncol

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Breast cancer is the most frequently diagnosed cancer in women, with an estimated 231,840 new cases representing 14.0% of all new cancer cases in the United States in 2015. Early screening and modern techniques of imaging and diagnosis have led to a significant improvement in detecting early-stage breast cancers and to a decrease in the incidence of metastatic breast cancer (MBC). About 20%-30% of patients who are initially diagnosed with an early-stage, nonmetastatic breast cancer will subsequently develop a distant metastatic disease. Between 6%-10% of the new breast cancer cases present initially as stage IV, referred to as de novo MBC. The most common sites of breast cancer metastases are lymph nodes, chest wall, skeleton, lung, skin, and the central nervous system (CNS). Lobular carcinoma, in particular, may metastasize to the gastrointestinal tract, peritoneum, and retroperitoneum. Gallbladder metastasis from breast cancer is very rare, and only 15-20 cases have been reported in the literature. Most of those cases have been associated particularly with a lobular histology. We report an additional rare case of MBC to the gallbladder, but with a ductal histology.

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“…There are many reports of secondaries to the gall bladder from the breast primary but only single case of gall bladder cancer metastasis to unilateral breast has been described till date. [1][2][3] Hence our case will be the first to be reported having bilateral breasts metastases from gall bladder primary.…”

Section: Introductionmentioning

confidence: 99%

Bilateral breasts metastases from gall bladder adenocarcinoma: a rare presentation

et al. 2019

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Bilateral breasts metastasis from gallbladder adenocarcinoma is very rare and has never been reported. Overall incidence of breast metastasis from other primaries as reported in literature is 0.5-3%. A 38 year female presented with progressive abdominal distension followed by lumps in the left and right breasts consecutively. Abdominal examination revealed a huge right upper quadrant lump, hard in consistency and moving with respiration. CT abdomen suggested gallbladder lump infiltrating liver, colon, duodenum and pylorus. HRUSG of breasts revealed malignant lumps. Histopathology and immuno-histochemistry of breast biopsy confirmed it to be metastatic and not the primary (mammaglobin-, GATA 3 -, CK 19+, GCDFP-). Gallbladder biopsy showed adenocarcinoma with similar marker pattern. A diagnosis of gallbladder carcinoma with secondaries in bilateral breasts was made. Patient received one cycle of platinum based palliative chemotherapy and thereafter was lost to follow up. A proper clinical, radiological and histopathological examination is essential to distinguish primary and metastatic breast lesion due to the difference in the management of both. Overall prognosis is very poor and treatment should be directed towards palliative therapy of primary malignancy.

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Bilateral synchronous breast carcinomas followed by a metastasis to the gallbladder: a case report

Cited by 25 publications

References 10 publications

Bilateral breast cancer in a Nigerian community

Bilateral breast cancer in a Nigerian community

Inflammatory metastatic breast cancer with gallbladder metastasis: an incidental finding

Bilateral breasts metastases from gall bladder adenocarcinoma: a rare presentation

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