Inflammatory metastatic breast cancer with gallbladder metastasis: an incidental finding

Ebrahim, Hassan Y.; Graham, David L.; Rice, David C.; Ribadeneyra, Michael; Thorner, Kim; Shipley, W.; Wehmueller, Michael

doi:10.12788/jcso.0154

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Documented metastases to the GB from distant sites are very rare and most commonly found with malignant melanoma (<50 case reports), cervical carcinoma, renal cell carcinoma, and non-small cell lung cancer [9,10,11]. Only one case report of IBC metastatic to the GB was identified [12]. No case report of IBC metastatic to both liver and GB was identified in the literature.…”

Section: Introductionmentioning

confidence: 99%

Metastatic Breast Cancer Presenting as Acute Cholecystitis and Hyperbilirubinemia

Guloyan¹,

Paul²,

Lee³

2020

AJSCCR

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Acute cholecystitis is one of the most common reasons for acute surgical intervention in the emergency setting [1]. Rarely, pathological examination of the surgical specimen reveals incidental gallbladder cancer and even more infrequently metastasis of gallbladder from a distant site. We present a case of a patient with a known history of inflammatory breast carcinoma, who presented with symptoms of right upper quadrant pain and jaundice and diagnostic work-up consistent with acute cholecystitis, subsequently found to have metastatic breast cancer to the liver and gallbladder.

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Section: Introductionmentioning

confidence: 99%

Metastatic Breast Cancer Presenting as Acute Cholecystitis and Hyperbilirubinemia

Guloyan¹,

Paul²,

Lee³

2020

AJSCCR

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A resected case of gallbladder metastasis with symptoms of acute cholecystitis in multiple metastatic ductal carcinoma of the breast

Urade

Oka

Iimori

et al. 2018

Clin J Gastroenterol

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Gallbladder metastasis from breast cancer, especially from ductal carcinoma, is rare. Herein, we report a rare case of gallbladder metastasis from ductal carcinoma of the breast that was diagnosed after laparoscopic cholecystectomy (LC) for acute cholecystitis. A 78-year-old woman presented with right upper abdominal tenderness and positive Murphy's sign during chemotherapy for advanced multiple metastases of the breast cancer. Abdominal ultrasonography and computed tomography showed a slightly thickened gallbladder wall and two calculi. After a diagnosis of acute calculous cholecystitis was established, LC was performed. Pathological examination revealed poorly differentiated adenocarcinoma infiltrating the submucosal and subserosal layer over the entire gallbladder, and a lymph node metastasis in the gallbladder neck. Immunohistochemical examination revealed that the tumor cells tested positive for estrogen receptor and negative for progesterone receptor, which was consistent with primary breast cancer. The patient was uneventfully discharged without abdominal pain 7 days later. Although she subsequently underwent several chemotherapies, she died 16 months later. In conclusion, gallbladder metastasis should be considered in patients with multiple metastatic breast cancer who present with signs or symptoms of cholecystitis. Moreover, LC should be considered to relieve the symptoms of cholecystitis for improved prognosis, even in a patient with multiple metastases.

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Case Report: Metastatic breast cancer to the gallbladder

et al. 2020

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Cholecystitis is one of the leading causes of emergency surgical interventions; the occurrence of metastases to the gallbladder is rare and has only been reported in the literature exceptionally. Metastatic breast cancer to the gallbladder is even less frequent; in fact, breast cancer usually metastasizes to bone, lung, lymph nodes, liver and brain. We report the case of an 83-year-old female patient with a previous history of breast surgery with axillary dissection in 1997, followed by adjuvant chemotherapy due to invasive ductal carcinoma of the left breast. The patient was admitted at the emergency department for sepsis and an episode of acute kidney failure, anuria and fever. Right-upper quadrant abdominal pain triggered by food intake and abdominal tenderness was also present, placing the diagnostic suspicion of biliary sepsis due to acute cholecystitis. The histological examination of the surgical specimen highlighted the presence of metastasis from an infiltrating ductal breast carcinoma with positive hormone receptors. We also report here the results of a review of the literature looking at articles describing cases of gallbladder metastasis from breast cancer.

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Inflammatory metastatic breast cancer with gallbladder metastasis: an incidental finding

Cited by 4 publications

References 13 publications

Metastatic Breast Cancer Presenting as Acute Cholecystitis and Hyperbilirubinemia

Metastatic Breast Cancer Presenting as Acute Cholecystitis and Hyperbilirubinemia

A resected case of gallbladder metastasis with symptoms of acute cholecystitis in multiple metastatic ductal carcinoma of the breast

Case Report: Metastatic breast cancer to the gallbladder

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