1988
DOI: 10.1001/archneur.1988.00520270029016
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Bilateral Symmetry of Cholinergic Deficits in Alzheimer's Disease

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Cited by 30 publications
(6 citation statements)
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“…However, only few post‐mortem studies have addressed the hemispheric asymmetry in pathology distribution, some reporting no asymmetries [Arnold et al, ], while others suggesting selective hemispheric asymmetries (L > R) of senile plaques and neurofibrillary tangles (tau) in AD [Moossy et al, ; Stefanits et al, ]. However, the reported asymmetries were limited to the entorhinal cortex and hippocampus but were not found in other cortical regions such as frontal and temporal cortex and basal nucleus of Meynert [Zubenko et al, ], and seemed to diminish with increasing disease severity [Moossy et al, ], pointing to their changing patterns during disease progression.…”
Section: Discussionmentioning
confidence: 99%
“…However, only few post‐mortem studies have addressed the hemispheric asymmetry in pathology distribution, some reporting no asymmetries [Arnold et al, ], while others suggesting selective hemispheric asymmetries (L > R) of senile plaques and neurofibrillary tangles (tau) in AD [Moossy et al, ; Stefanits et al, ]. However, the reported asymmetries were limited to the entorhinal cortex and hippocampus but were not found in other cortical regions such as frontal and temporal cortex and basal nucleus of Meynert [Zubenko et al, ], and seemed to diminish with increasing disease severity [Moossy et al, ], pointing to their changing patterns during disease progression.…”
Section: Discussionmentioning
confidence: 99%
“…Several authors have described asymmetries in the neuronal number of the BFC. 21 , 28 - 32 Special focus was directed on Ayala’s nucleus whose asymmetry was explained by its cholinergic axons to Broca’s speech area. 6 , 17 We succeeded in visualizing size and shape differences of the periputaminal or lateral Ayala’s subnucleus by computer-assisted 3D reconstruction.…”
Section: Methodsmentioning
confidence: 99%
“…Our findings are consistent with early reports on the extent of left–right symmetry in the cholinergic deficits in AD brains, which was found to be symmetrically distributed compared to more asymmetrical morphological lesions. 47 , 48 …”
Section: Discussionmentioning
confidence: 99%