2007
DOI: 10.1590/s1980-57642008dn10200005
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Computer-assisted 3D reconstruction of the human basal forebrain complex

Abstract: The basal forebrain complex (BFC) is a small but intricate structure. Its organization and function is hard to investigate using conventional methods, especially in humans. By combining new methods of research we present a comprehensive overview of this complex, in order to better understand its function in normal and diseased brains.MethodsThe right and left BFC of a 29-year-old male were reconstructed from gallcocyanin (Nissl) stained 440 µm-thick serial horizontal sections by using advanced computer-assiste… Show more

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Cited by 15 publications
(29 citation statements)
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“…Subsequently, each section profile was traced on the digital pictures with the help of a graphic tablet. [39,40].…”
Section: Methodsmentioning
confidence: 99%
“…Subsequently, each section profile was traced on the digital pictures with the help of a graphic tablet. [39,40].…”
Section: Methodsmentioning
confidence: 99%
“…The NbM is located within the substantia innominata of the basal forebrain, ventrally to the anterior part of the thalamus and putamen ([27,135]; Figure 1F). There is an evolutionary trend towards size increase and differentiation in this nucleus, with primates and cetaceans showing the highest development [136].…”
Section: Basal Nucleus Of Meynert and The Cholinergic Systemmentioning
confidence: 99%
“…For further details, see Schmitz and Hof. (2005), Heinsen et al (2000), Grinberg and Heinsen (2007b) and Grinberg et al (2008). Finally, routine histological methods, stereological techniques, immunohistochemistry, and quantitative studies can be applied in the same areas, which allows the correlation of the findings of cellular and molecular pathology and deeper understanding of the regional pathophysiology (Grinberg et al 2008(Grinberg et al , 2009a.…”
Section: Heinsen's Methods For Celloidin Embeddingmentioning
confidence: 98%