Bilateral Spontaneous Rupture of Achilles Tendons: A Case Report

Rao, S N; Navadgi, B. C.; Vasdev, Attique

doi:10.1177/230949900501300214

Cited by 22 publications

(14 citation statements)

References 5 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hayes, et al [19] presented their case and suggested that smoking may have been a causative factor. Rao, et al [21] reported another case but their patient had hypothyroidism and was taking thyroxine and they surmised that hypercholesterolemia and hypothyroidism lead to degenerate tendon which eventually ruptured. Habusta [9] reported two cases in healthy patients however both patients had long term Achilles tendonitis and were gymnasts.…”

Section: Discussionmentioning

confidence: 99%

Conservative Management of Bilateral Tendoachilles (TA) Rupture—A Case Report

Kakkar¹,

Chambers²,

Scott³

2011

View full text Add to dashboard Cite

Tendo Achilles ruptures are generally traumatic in origin and while bilateral tendo Achilles ruptures are a rare occurrence, most of them are associated with risk factors or pre-existing disease and generally involve trauma or sporting activities. Most of the cases of bilateral rupture are generally treated operatively. A spontaneous onset case of bilateral tendo achilles rupture is reported in a healthy man and its conservative (non operative) management discussed with a review of the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Conservative Management of Bilateral Tendoachilles (TA) Rupture—A Case Report

Kakkar¹,

Chambers²,

Scott³

2011

View full text Add to dashboard Cite

show abstract

“…Les premières descriptions rapportant l'association de cette rupture à une corticothérapie au long cours ont été faites dans les années 1960 [8][9][10]. Elles surviennent le plus souvent sur un tendon altéré par une maladie nécessitant le traitement cortisonique [11].…”

Section: Discussionunclassified

Spontaneous bilateral rupture of the Achilles tendon: a case report

et al. 2007

View full text Add to dashboard Cite

Les auteurs rapportent une observation de rupture bilatérale du tendon d'Achille, chez un patient asthmatique sous corticothérapie au long cours. Ils évoquent les différentes étiologies incriminées. Ils discutent le rôle de la corticothérapie dans la genèse de cette rupture et pré-conisent une réparation chirurgicale des tendons. Mots clés : Tendon d'Achille -Rupture spontanée bilatérale -CorticothérapieAbstract: The authors report a case of spontaneous bilateral rupture of the Achilles tendon in a patient with asthma undergoing long-term steroid therapy. They review various aetiologies of the disorder and discuss the effect of steroid therapy on tendon rupture. They advocate surgical repair.

show abstract

“…However, only a few studies have reported a link between oral GCs and the risk of Achilles tendon rupture [5,6]. Considering occasional case reports of patients receiving long-term GC treatment due to systematic diseases or autoimmune disorders, who experienced spontaneous Achilles tendon rupture [7][8][9], it is important to determine the exact mechanism by which the Achilles tendon is weakened by GC.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of type I collagen expression in the Achilles tendon by dexamethasone: a controlled laboratory study

Tang

Chen

et al. 2020

J Orthop Surg Res

View full text Add to dashboard Cite

Background: Spontaneous Achilles tendon rupture associated with long-term dexamethasone (Dex) use has been reported. However, few studies have investigated the potential mechanism. The aim of this study was to evaluate the effects of oral Dex on type I collagen in humans and rats and its association with tendon rupture. Methods: First, six Achilles tendons from patients who received long-term Dex treatment, and another six normal tendons were harvested for histological evaluation. Secondly, 8-week-old rats (n = 72) were randomly assigned to a Dex group or a control group. Type I collagen was studied at the mechanical, histological, and molecular levels after 3 and 5 weeks. Tenocytes isolated from normal human and rat tendon were used to investigate the effect of Dex on cellular scale. Results: Histological analysis of human and rat tendon tissue revealed an irregular, disordered arrangement of type I collagen in the Dex group compared with the control group. In addition, In the Dex+ group, type I collagen expression decreased in comparison with the Dex− group in both human and rat tenocytes. The mechanical strength of tendons was significantly reduced in the Dex group (68.87 ± 11.07 N) in comparison with the control group (81.46 ± 7.62 N, P = 0.013) after 5 weeks. Tendons in the Dex group were shorter with smaller cross-sectional areas (10.71 ± 0.34 mm 2 , 1.44 ± 0.22 mm 2 , respectively) after 5 weeks than those in the control group (11.13 ± 0.50 mm 2 , P = 0.050, 2.74 ± 0.34 mm 2 , P < 0.001, respectively). Conclusions: This finding suggests long-term use of Dex that decreases the expression of type I collagen at molecular and tissue levels both in human and rat Achilles tendons. Furthermore, Dex decreases the mechanical strength of the tendon, thereby increasing the risk of Achilles tendon rupture.

show abstract

Bilateral Spontaneous Rupture of Achilles Tendons: A Case Report

Cited by 22 publications

References 5 publications

Conservative Management of Bilateral Tendoachilles (TA) Rupture—A Case Report

Conservative Management of Bilateral Tendoachilles (TA) Rupture—A Case Report

Spontaneous bilateral rupture of the Achilles tendon: a case report

Downregulation of type I collagen expression in the Achilles tendon by dexamethasone: a controlled laboratory study

Contact Info

Product

Resources

About