Bilateral Retrobulbar Optic Neuritis, Guillain-Barre Syndrome and Asymptomatic Central White Matter Lesions Following Adult Measles Infection

Tomiyasu, Kazuhiro; Ishiyama, Masaya; K, Kato; Komura, Masayoshi; Ohnuma, Eri; Inamasu, Joji; Takahashi, Toshiyuki

doi:10.2169/internalmedicine.48.1585

Cited by 12 publications

(9 citation statements)

References 20 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anterior ON or papillitis due to measles infection was reported previously in several patients without other neurological deficits [4,5,6,7]. Little is known about measles-associated retrobulbar ON [2, 3, 8]. Here, we report a distinct patient with unilateral measles-associated retrobulbar ON.…”

Section: Introductionmentioning

confidence: 53%

“…Measles virus can generate various types of neurological complications [1, 2]. This neurotrophic virus is known to provoke acute ON together with CNS deficits or encephalitis [3, 8].…”

Section: Discussionmentioning

confidence: 99%

“…Measles virus, a neurotrophic virus, is known to cause various kinds of neurological complications [1, 2], with a frequency of 4 neurological insults per 1,000 cases of measles infection. Measles encephalitis or impaired consciousness was observed in 1 per 1,000 cases [1] and commonly in children or adults >10 years of age [1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unilateral Measles-Associated Retrobulbar Optic Neuritis without Encephalitis: A Case Report and Literature Review

Hirayama

Ikeda

Hidaka³

et al. 2010

Case Rep Neurol

View full text Add to dashboard Cite

Optic neuritis (ON) is a rare neurological complication of measles infection. Little is known about measles-associated retrobulbar ON. Here, we report a distinct patient with unilateral retrobulbar ON due to measles infection. A 26-year-old woman developed maculopapular rash and Koplik spots. On the following 3 days, she noticed blurred vision in the left eye. A Goldmann visual field test showed inferior nasal quadrantanopsia in the left eye. Visual acuity was 20/20 in OD and 20/100 in OS. Pupillary size was 2.0 mm in the right eye and 4.0 mm in the left eye. Light reflexes were slightly sluggish in the left eye. Ophthalmoscopy showed mild pallor of the left optic disc. Central critical flicker fusion frequency (CFF) was 40.7 Hz in the right eye and 10.1 Hz in the left eye (normal ≧29.0). Visual evoked potentials showed that P100 latencies were delayed on the left side (133 ms). Brain and spinal cord MRI was normal. Orbital MRI displayed abnormal enhancement in the left optic nerve. Serum and cerebrospinal fluid IgG titers of anti-measles antibodies were increased. Left measles-associated ON was diagnosed. Methylprednisolone pulse therapy followed by oral administration of prednisolone ameliorated visual acuity, visual field and CFF. The neuroophthalmic profile of our patient indicated that measles infection triggered isolated retrobulbar ON, leading to unusual visual deficits. Thus, physicians should pay more attention to variable patterns of measles-associated ON.

show abstract

Section: Introductionmentioning

confidence: 53%

“…Measles virus can generate various types of neurological complications [1, 2]. This neurotrophic virus is known to provoke acute ON together with CNS deficits or encephalitis [3, 8].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unilateral Measles-Associated Retrobulbar Optic Neuritis without Encephalitis: A Case Report and Literature Review

Hirayama

Ikeda

Hidaka³

et al. 2010

Case Rep Neurol

View full text Add to dashboard Cite

show abstract

“…Signs and symptoms of measles include cough, runny nose, sore throat, fever, and a red, blotchy skin rash. Optic nerve involvement, including optic neuritis and retrobulbar optic neuropathy, is a rare complication of measles that may affect children or adults with or without associated encephalomyelitis 94–98. Optic neuritis usually occurs about 1 week after the onset of initial symptoms.…”

Section: Other Virusesmentioning

confidence: 99%

“…Optic neuritis usually occurs about 1 week after the onset of initial symptoms. The prognosis is generally favorable with recovery of good visual acuity after corticosteroid therapy 94–98…”

Section: Other Virusesmentioning

confidence: 99%

Infectious optic neuropathies: a clinical update

Kahloun¹,

Abroug²,

Ksiaa³

et al. 2015

View full text Add to dashboard Cite

Different forms of optic neuropathy causing visual impairment of varying severity have been reported in association with a wide variety of infectious agents. Proper clinical diagnosis of any of these infectious conditions is based on epidemiological data, history, systemic symptoms and signs, and the pattern of ocular findings. Diagnosis is confirmed by serologic testing and polymerase chain reaction in selected cases. Treatment of infectious optic neuropathies involves the use of specific anti-infectious drugs and corticosteroids to suppress the associated inflammatory reaction. The visual prognosis is generally good, but persistent severe vision loss with optic atrophy can occur. This review presents optic neuropathies caused by specific viral, bacterial, parasitic, and fungal diseases.

show abstract