Bilateral Retinal Detachments in a Healthy 22-year-old Woman After Moderna SARS-COV-2 Vaccination

Subramony, Rachna; Knight, Darren; Aminlari, Amir; Belovarski, Ioan

doi:10.1016/j.jemermed.2021.07.034

Cited by 19 publications

(13 citation statements)

References 15 publications

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“…As a follow up to this, two recent case reports published in the USA reveal a possible association with mRNA vaccines and damage to the retina. Subramony et al [22], for example, reported a case of bi-lateral retinal detachment in a healthy 22-year-old after vaccination with the Moderna mRNA vaccine. This individual had no health issues, but upon ophthalmologic exam, was determined to have lattice degeneration.…”

Section: Lipid Nanoparticles (Lnps) In the Covid-19 Mrna Vaccinesmentioning

confidence: 99%

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

et al. 2021

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Vaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing fetus and neonate, remains to be determined. A global effort has been underway to encourage pregnant women to get vaccinated despite the uncertain risk posed to them and their offspring. Given this, post-hoc data collection, potentially for years, will be required to determine the outcomes of COVID-19 and vaccination on the next generation. Most COVID-19 vaccine reactions include injection site erythema, pain, swelling, fatigue, headache, fever and lymphadenopathy, which may be sufficient to affect fetal/neonatal development. In this review, we have explored components of the first-generation viral vector and mRNA COVID-19 vaccines that are believed to contribute to adverse reactions and which may negatively impact fetal and neonatal development. We have followed this with a discussion of the potential for using an ovine model to explore the long-term outcomes of COVID-19 vaccination during the prenatal and neonatal periods.

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Section: Lipid Nanoparticles (Lnps) In the Covid-19 Mrna Vaccinesmentioning

confidence: 99%

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

et al. 2021

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“…Starting from an analysis of the literature on eye complications of COVID-19 vaccines, it is evident that nevertheless trillions of vaccine administrations ocular side effects generally are very rare, less than one hundred severe ophthalmological side effects are described in normal population in the last three years either in registration trials or in literature. [8][9][10][11][12] Main ocular complication are inflammatory manifestations both in anterior or posterior segment, and ocular thrombosis or ischemic manifestations, [13][14][15][16][17] occurred in strict time relation, one to three days, with vaccine shot release. [23][24][25][26][27][28][29][30][31][32] But no reports are present on the occurrence of side effects in patients affected by rare ophthalmological disease.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccines in Inherited Retinal Degenerations (IRD), Fears, Ideas and Real Interactions

Vingolo

2022

OPTH

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In the COVID-19 pandemic era, vaccines are one of the most efficient weapons, as well established by WHO, that humans have, in all their variants (mRNA, AAV or others). Unfortunately, in western nations skepticism within different groups has been generated by the fast approval processes, driven by the urgent need to confront the rapid increase of hospitalized patients and number of deaths by regulation authorities as FDA and EMA. Moreover, several scientific and non-scientific perplexity, also amplified by the media, created hard no-vax strategies, that lead many patients to refuse vaccine administration. Also in this selected population higher rate of COVID-19 infections and severe diseases are registered and consequently there was an increase of death number. Furthermore, to avoid vaccine shots, people frequently ask exemption querying ophthalmological and systemic diseases, in this situation most patients affected with orphan ophthalmological conditions as inherited retinal degenerations have profound fears and doubt. The goal of our study was to ascertain if these fears are based on real facts and if there are interactions or severe visual impairment after each shot of vaccinations. Methods: Five hundred randomically selected patients affected by IRD at each patient was asked anonymously, number of vaccine administrations and eventually reported side effects. Results: Of 500 selected patients 61 (12,2%) did not underwent to Covid-19 vaccination, reasons were various (fear, laziness, caregiver unavailability etc.). Remaining 439 patients (87,8%) had first shot of vaccine. Only 30% of patients complained side effects of vaccine, none of them was serious. Conclusion:The number of patients is wide enough to draw some considerations: In IRD vaccination is safe, in all doses ocular side effects were reported only in one third of subjects and this is not different from the percentage shown by normal people, COVID-19 effects may be more dangerous than vaccine.

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“…All 4 reported cases were in females, which is in conjunction with findings by [ 204 ] fuelling the possibility of further clinical analysis regarding any relationship between sex and occurrence of hypersensitivity reactions after administration of the mRNA-1273 vaccine. A 22 years old myopic female in the USA experienced bilateral retinal detachment after vaccination with mRNA-1273 [ 210 ]. In July 2021, EMA confirmed myocarditis and pericarditis as side effects of mRNA-1273 [ 211 ].…”

Section: Vaccines Approved For Public Usementioning

confidence: 99%

Counting on COVID-19 Vaccine: Insights into the Current Strategies, Progress and Future Challenges

et al. 2021

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The emergence of a novel coronavirus viz., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 and its subsequent substantial spread produced the coronavirus disease 2019 (COVID-19) pandemic worldwide. Given its unprecedented infectivity and pathogenicity, the COVID-19 pandemic had a devastating impact on human health, and its clinical management has been a great challenge, which has led to the development and speedy trials of several vaccine candidates against SARS-CoV-2 at an exceptional pace. As a result, several COVID-19 vaccines were made commercially available in the first half of 2021. Although several COVID-19 vaccines showed promising results, crucial insights into their epidemiology, protective mechanisms, and the propensities of reinfection are not largely reviewed. In the present report, we provided insights into the prospects of vaccination against COVID-19 and assessed diverse vaccination strategies including DNA, mRNA, protein subunits, vector-based, live attenuated, and inactivated whole/viral particle-based vaccines. Next, we reviewed major aspects of various available vaccines approved by the World Health Organization and by the local administrations to use against COVID-19. Moreover, we comprehensively assessed the success of these approved vaccines and also their untoward effects, including the possibility of reinfection. We also provided an update on the vaccines that are under development and could be promising candidates in the future. Conclusively, we provided insights into the COVID-19 vaccine epidemiology, their potency, and propensity for SARS-CoV-2 reinfection, while a careful review of their current status, strategies, success, and future challenges was also presented.

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Bilateral Retinal Detachments in a Healthy 22-year-old Woman After Moderna SARS-COV-2 Vaccination

Cited by 19 publications

References 15 publications

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

COVID-19 Vaccines in Inherited Retinal Degenerations (IRD), Fears, Ideas and Real Interactions

Counting on COVID-19 Vaccine: Insights into the Current Strategies, Progress and Future Challenges

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