Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

Karrow, Niel A.; Shandilya, Umesh K.; Pelech, Steven; Wagter-Lesperance, Lauraine; McLeod, Deanna; Bridle, Byram W.; Mallard, Bonnie A.

doi:10.3390/vaccines9111351

Cited by 11 publications

(5 citation statements)

References 153 publications

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“…Furthermore, risk estimates would have moved toward null because of the potential disadvantages of viral vector vaccines. 29 Given that uncertainties remain regarding the timing of pregnancy loss and bias determination from the self-selection of vaccinated groups, more reproducible methodologies to assess vaccination safety during pregnancy would need to be developed.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of COVID-19 Vaccination During Preconceptional and Preclinical Pregnancy Period: A National Population Study

Gwak,

Kim,

Shin

et al. 2023

J Korean Med Sci

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Background We aimed to assess the risk of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and early abortive outcomes after the association between coronavirus disease 2019 (COVID-19) vaccination during the preconceptional period and preclinical pregnancy, which are likely to be inadvertent vaccination. Methods We used data from the Korea Disease Control and Prevention Agency-COVID19-National Health Insurance Service cohort from December 2020 to December 2021. The vaccinated pregnant women were matched to unvaccinated pregnant controls at a 1:4 ratio. The risks of SARS-CoV-2 infection and intensive care unit (ICU) admission within 14 days of infection were analyzed to assess its effectiveness. For safety measures, the adjusted relative risks (aRRs) of early abortive outcomes for the first COVID-19 vaccination during the preconceptional and preclinical periods were calculated considering covariates. We compared the risk of early abortion between mRNA and viral vector vaccines. Results The overall COVID-19 vaccination rates during the preconceptional period and preclinical pregnancy were 3.1% (6,662/215,211) and 2.6% (5,702/215,211), respectively. The cumulative incidence of ICU admission within 14 days of SARS-CoV-2 infection was 6/100,000 in the unvaccinated group, whereas there were no ICU admissions in the vaccinated groups. The risks of early abortive outcomes were not significantly different between the preconceptional vaccination group and the unvaccinated group (aRR, 1.04; 95% confidence interval [CI],0.99–1.10) or between preclinical pregnancy vaccination and their matched controls (1.02; 95% CI, 0.96–1.08). mRNA and viral vector vaccines have shown similar risks for early abortive outcomes and miscarriages. Conclusion Our findings have provided compelling evidence regarding the effectiveness and safety of COVID-19 vaccination prior to and during early pregnancy. Further research is required to extend the safety and efficacy profiles of COVID-19 vaccines to pregnant women and their babies.

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Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of COVID-19 Vaccination During Preconceptional and Preclinical Pregnancy Period: A National Population Study

Gwak,

Kim,

Shin

et al. 2023

J Korean Med Sci

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“…In addition, spontaneous abortions and stillbirths could be expected when the mother has been vaccinated 258,278 , either recently before or during pregnancy 279 . The movement of nutrient-rich HSA across the placental barrier is controlled by clathrin-enabled endocytosis.…”

Section: Endocrine Disorders Reproductive Health and Pregnancymentioning

confidence: 99%

COVID-19 vaccine adverse events: Evaluating the pathophysiology from an undersulfated and degraded glycocalyx perspective

Preez,

Lin,

Maguire

et al. 2023

Preprint

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In this literature review, we assess the pathophysiology of severe adverse events observed after vaccination with DNA and mRNA vaccines against COVID-19, despite reports of their overall effectiveness. The focus is on the perspective of an undersulfated and degraded glycocalyx, considering its impact on immunomodulation, inflammatory responses, coagulation, and oxidative stress. The paper explores various factors that lead to glutathione and inorganic sulfate depletion and their subsequent effect on glycocalyx sulfation and other metabolites, including hormones. Components of COVID-19 vaccines, such as DNA and mRNA material, spike protein antigen, and lipid nanoparticles, are involved in possible cytotoxic effects. The common thread connecting these adverse events is endotheliopathy or glycocalyx degradation caused by depleted glutathione and inorganic sulfate levels, shear stress from circulating nanoparticles, aggregation, and formation of protein coronas, leading to imbalanced immune responses and chronic release of pro-inflammatory cytokines, ultimately resulting in oxidative stress and systemic inflammatory response syndrome. By understanding the underlying pathophysiology of severe adverse events, better treatment options can be explored.

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“…The long-term outcomes are unknown. Karrow et al note that animal models suggest significant concerns for the use in pregnancy [62]. In their review of COVID-19 vaccine reactions in humans, they include among symptoms injection site erythema, pain, swelling, fatigue, headache, fever, and lymphadenopathy.…”

Section: Let's Work Together To Change Coursementioning

confidence: 99%

“…vaccines that are believed to contribute to adverse reactions, and which may negatively impact fetal and neonatal development [62].…”

Section: Let's Work Together To Change Coursementioning

confidence: 99%

Patient Betrayal: The Corruption of Healthcare, Informed Consent and the Physician-Patient Relationship

Thorp¹,

Renz²,

Northrup³

et al. 2022

G Med Sci

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The purpose of this study is: first, to review disciplinary threats made to healthcare professionals by their governing bodies in the US; and second, to review medical literature for complications related to the COVID-19 vaccines and data from the Vaccine Adverse Event Reporting System (VAERS), particularly those related to pregnant women and women of reproductive age. The authors also aim to bring attention to the populace, healthcare workers, and healthcare administrators that illegal and unconstitutional gag orders have been placed on all healthcare workers in the US, and to alert everyone that no healthcare worker can be trusted since they are under a gag order which renders informed consent null and void. It is our intent to put governing bodies of healthcare workers on notice that they will be held accountable and lay legal groundwork for possible Racketeer Influenced and Corrupt Organizations Act (RICO) violations, collusion, and fraud. These potential criminal acts, exposed in a court of law, can pierce legal immunity of Big Pharma and others, and pierce any perceived immunity given to hospitals and organizations via the CARES ACT.

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Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

Cited by 11 publications

References 153 publications

Effectiveness and Safety of COVID-19 Vaccination During Preconceptional and Preclinical Pregnancy Period: A National Population Study

Effectiveness and Safety of COVID-19 Vaccination During Preconceptional and Preclinical Pregnancy Period: A National Population Study

COVID-19 vaccine adverse events: Evaluating the pathophysiology from an undersulfated and degraded glycocalyx perspective

Patient Betrayal: The Corruption of Healthcare, Informed Consent and the Physician-Patient Relationship

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