Bilateral Primary Renal Non-Hodgkin’s Lymphoma Presenting with Acute Renal Failure: Successful Treatment with Systemic Chemotherapy

Choi, Jin Hyuk; Choi, Gyu Bog; Shim, Ki Nam; Sung, Sun Hee; Han, Woon Sup; Baek, Seung Yon

doi:10.1159/000203690

Cited by 38 publications

(18 citation statements)

References 13 publications

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“…Sonographic lesions in human primary renal lymphoma may persist despite resolution of symptoms and histopathologic absence of disease (Choi et al . ).…”

Section: Discussionmentioning

confidence: 97%

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma

Taylor

Finotello

Saavedra

et al. 2019

J of Small Animal Practice

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Objectives To characterise the presentation, clinicopathologic data and outcome of 29 dogs with presumed primary renal lymphoma. Materials and Methods Retrospective analysis of medical records of dogs with suspected primary renal lymphoma from 11 institutions. Results All dogs were substage b, and lethargy and gastrointestinal signs were common presenting complaints, as were azotaemia (n=25; 86%) and erythrocytosis (n=15; 51%) on biochemical testing. Ultrasonography typically revealed bilateral renal lesions (n=23; 79%), renomegaly (n=22; 76%) and abdominal lymphadenopathy (n=14; 48%). Chemotherapy was the only treatment in 23 dogs, of which 11 responded, all considered partial responses. For all dogs the median progression‐free survival and median overall survival times were 10 days (range: 1 to 126) and 12 days (range: 1 to 212), respectively, and for dogs that responded to chemotherapy 41 days (range: 10 to 126) and 47 days (range: 10 to 212), respectively. Clinical Significance Primary renal lymphoma in dogs appears to be associated with a poor prognosis and short‐lived response to chemotherapy.

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“…Sonographic lesions in human primary renal lymphoma may persist despite resolution of symptoms and histopathologic absence of disease (Choi et al . ).…”

Section: Discussionmentioning

confidence: 97%

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma

Taylor

Finotello

Saavedra

et al. 2019

J of Small Animal Practice

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“…vant radiotherapy should be considered [13], although the preservation of renal function in view of chemotherapy is an issue. Despite the usually poor prognosis, long-term survival may be achieved with aggressive multimodal therapy [12,14]. Intensive chemotherapy should be instituted early on in order to prevent rapid dissemination and progressive renal failure [6,10].…”

Section: Discussionmentioning

confidence: 99%

Primary Renal Non-Hodgkin’s Lymphoma – a Difficult Differential Diagnosis

Gellrich

Hakenberg²,

Naumann³

et al. 2002

Oncol Res Treat

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Introduction: Primary renal lymphoma (PRL) as a clinical entity is not undisputed because the kidneys do not contain lymphatic tissue and the mechanism of development of PRLs is unclear. Most of the few cases reported showed rapid systemic progression and a poor prognosis. Although there are no clearly defined diagnostic criteria for renal lymphomas, abdominal and thoracic computed tomography as well as renal and bone marrow biopsy are recommended. 3 cases of renal lymphoma are reported and their diagnosis and management discussed. Case Reports: Between 1996 and 2001, 3 male patients with renal lymphoma were diagnosed and treated at our institution. In patient No. 1, because of persisting macroscopic hematuria a bilateral PRL was diagnosed by renal biopsy, without any detectable lesions on CT imaging. Patient No. 2 presented with a large renal mass which, on biopsy, was diagnosed as a lymphoma. Patient No. 3 showed lymphoma on renal biopsy and bone marrow involvement. All 3 patients were treated with systemic chemotherapy which resulted in death of disease in 2 patients and a complete remission in 1 patient after adjuvant radiotherapy and nephrectomy. Conclusion: PRL represents a rare entity which must nevertheless be considered in cases of unusual renal masses or otherwise unexplained renal symptoms. If diagnosed early, cure is possible, and multimodal treatment should be considered.

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“…Occasionally, patients present with nonspecific signs and symptoms including flank pain, weight loss, hematuria, or a palpable mass (11). Acute renal failure from lymphomatous infiltration has also been described but is quite rare (12)(13)(14).…”

Section: Clinical and Histopathologic Features Of Renal Lymphoma Clinmentioning

confidence: 99%

Renal Lymphoma: CT Patterns with Emphasis on Helical CT

Urban

Fishman²

2000

RadioGraphics

160

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Renal lymphoma is most often seen in conjunction with multisystemic, disseminated lymphoma or as tumor recurrence. Renal lymphoma may also be seen in immunocompromised patients or, rarely, as primary disease. Computed tomography (CT) is the most sensitive, efficient, and comprehensive examination for evaluation of the kidneys in patients with suspected renal lymphoma. Helical CT in particular improves detection and characterization of lymphomatous renal involvement by optimizing contrast dynamics and data acquisition and is the current modality of choice for accurate staging of lymphoma. Typical CT patterns in renal lymphoma include single and multiple masses, invasion from contiguous retroperitoneal disease, perirenal disease, and diffuse renal infiltration. Atypical CT patterns may also be encountered and provide a diagnostic challenge. These include spontaneous hemorrhage, necrosis, heterogeneous attenuation, cystic transformation, and calcification. Solid renal masses including renal cell carcinoma and metastases are the most commonly encountered entities that mimic renal lymphoma at CT and require biopsy for definitive diagnosis. CT (particularly helical CT) is useful in the evaluation of patients with suspected renal lymphoma, and familiarity with the spectrum of findings in renal lymphoma is important for accurate diagnosis.

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Bilateral Primary Renal Non-Hodgkin’s Lymphoma Presenting with Acute Renal Failure: Successful Treatment with Systemic Chemotherapy

Cited by 38 publications

References 13 publications

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma

Primary Renal Non-Hodgkin’s Lymphoma – a Difficult Differential Diagnosis

Renal Lymphoma: CT Patterns with Emphasis on Helical CT

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