Renal Lymphoma: CT Patterns with Emphasis on Helical CT

Urban, Bruce A.; Fishman, Elliot K.

doi:10.1148/radiographics.20.1.g00ja09197

Cited by 160 publications

(95 citation statements)

References 33 publications

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“…Enhanced metastatic colonization of multiple organs in timp-3 À/À mice Lymphoma is known to metastasize the kidney in humans (Urban and Fishman, 2000). Therefore, we selected EL-4, a murine lymphoma cell line to further study kidney metastasis.…”

Section: Resultsmentioning

confidence: 99%

“…Proteolytic remodeling of the extracellular matrix (ECM) facilitates multiple stages of cancer dissemination including tumor angiogenesis, invasion, migration, extravasation and colonization of secondary site (Chang and Werb, 2001). The common sites of metastasis for solid tumors are the lung, liver, bone and brain, whereas lymphomas frequently affect the kidney (Urban and Fishman, 2000;Perez et al, 2001). These tissues have specific morphology, cellular and ECM composition, and levels of growth factors and cytokines, and provide a distinct 'soil' for the metastatic cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3−/− mice

et al. 2006

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Identifying versatile inhibitors of metastasis that operate in multiple sites against distinct cancer cell types is important for designing novel therapeutics for metastasis. We show that multiple tissues of timp-3 À/À mice are more susceptible to metastatic colonization. Overall, a 5-14-fold increase in liver and kidney colonization occurred by EL-4 lymphoma cells, and a twofold increase upon targeting B16F10 melanoma cells to the bone or lung of timp-3 À/À mice. There was a general lack of macrophage or neutrophil localization to metastases in the liver, kidney and lung, and of osteoclasts to bone in both genotypes. Analysis of lung showed that proliferation or angiogenesis were unaltered within the metastatic colonies. Lung-trap assays revealed that initial tumor cell trapping was similar in the lung vasculature of timp-3 À/À and wild-type mice. However, more tumor cells were found in timp-3 À/À lungs at 48 and 96 h after tumor cell injection indicating more efficient extravasation and initial proliferation. Activation of pro-MMP-2 was greater in timp-3 À/À lungs at these time points. These data demonstrate TIMP-3 functions to inhibit metastatic dissemination of diverse cancer cells to multiple organs. TIMP-3 regulates MMP-2 activation to limit tumor cell extravasation and subsequent colonization of the lung, without augmenting inflammatory cell response.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3−/− mice

et al. 2006

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“…8 In addition to lymphoma, differential diagnosis of multiple solid renal masses include benign primary neoplasms such as angiomylipomas and oncocytomas, malignant primary neoplasms such as renal cell carcinomas (RCC), metastases, leukemia, and non-neoplastic conditions such as pyelonephritis and infarction. 9,10 Lymphomatous involvement of the kidneys are rare; it is detected in only 3%-8% of patients undergoing CT staging for lymphoma. 9 Lymphoma typically involves the kidney in one of several recognizable patterns, including solitary or multiple renal masses, renal involvement from contiguous retroperitoneal or peritoneal disease, and diffuse renal infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 Lymphomatous involvement of the kidneys are rare; it is detected in only 3%-8% of patients undergoing CT staging for lymphoma. 9 Lymphoma typically involves the kidney in one of several recognizable patterns, including solitary or multiple renal masses, renal involvement from contiguous retroperitoneal or peritoneal disease, and diffuse renal infiltration. 9,10 Lymphomatous masses of the kidney tend to be homogeneous with mild enhancement, and exhibit little mass effect.…”

Section: Discussionmentioning

confidence: 99%

Burkitt Lymphoma: Involvement of Both Ovaries and Kidneys in an Adult: Case Report

Açar¹,

Tatlı²,

Sadow³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T Burkitt lymphoma is an uncommon type of non-Hodgkin lymphoma that often involves extranodal sites. The disease predominantly affects children and has an aggressive clinical course. We report the imaging findings of a 23-year-old woman with an atypical Burkitt lymphoma that involved both ovaries and kidneys. The patient has remained in complete remission three years after the initiation of treatment.

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“…This feature can facilitate the diagnosis, given the appropriate clinical history (27). However, on rare occasion lymphoma may initially present as a solitary renal mass or a homogeneous infiltrating renal mass (which can enlarge the kidney, which usually maintains a reniform shape) in a patient with no history of lymphoma (27)(28)(29). Renal lymphoma is characteristically hypovascular, which can be helpful in suggesting the proper diagnosis and differentiating it from RCC (which is typically more vascular).…”

Section: Lymphomamentioning

confidence: 99%

MRI of the kidney and urinary tract

Israel

2006

Magnetic Resonance Imaging

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MRI of the kidney and urinary tract has evolved with advancements in MR technology combined with further radiologic experience. A combination of simple pulse sequences and the use of gadolinium (Gd) allow a comprehensive evaluation of the genitourinary system and facilitate the detection and accurate characterization of renal and urinary tract masses. In this review an MRI technique used to evaluate the kidneys and urinary tract is presented with an emphasis on the characterization of renal masses. RECENT TECHNOLOGICAL ADVANCES have expanded the role of MRI in evaluating the kidney and the urinary tract. The high spatial resolution and intrinsic tissue contrast of MRI have resulted in superb detection and characterization of renal and urinary tract anatomy and pathology. Recently, new imaging methods (such as parallel imaging) have resulted in sequences with higher spatial resolution that are performed during shorter breath-holds. Gadolinium (Gd) can be administered to patients without concern for contrastinduced nephrotoxicity, and is well tolerated by patients with a history of iodinated-contrast allergy. The superior safety profile of Gd combined with the lack of ionizing radiation makes MRI an ideal modality for evaluating the genitourinary system, especially in patients who have renal disease or have undergone nephrectomy or partial nephrectomy. In this review the MRI findings of the kidneys and urinary system are discussed with an emphasis on differentiating renal masses and evaluating the collecting system. TECHNIQUEA comprehensive examination of the kidneys and collecting system includes an evaluation of the renal vasculature, parenchyma, and collecting system. Unenhanced imaging includes axial breath-hold T1-weighted gradient-echo (GRE) (performed in and out of phase), coronal or axial breath-hold T2-weighted half-Fourier single-shot fast spin-echo (FSE), and breath-hold frequency-selective fat-suppressed 3D T1-weighted spoiled GRE (Table 1) sequences. The 3D fat-suppressed T1-weighted sequence is also performed at multiple time points after intravenous Gd administration, and may be used to produce MR angiographic, venous, parenchymal, and excretory phase images. If it is necessary to determine the renal arterial anatomy (e.g., in patients about to undergo partial nephrectomy), this sequence should be performed in the oblique-coronal plane during an arterial phase. Using the proper scan delay and acquiring the low-spatial-frequency (high contrast) lines of k-space during peak arterial enhancement are critical for minimizing venous contamination and preventing scanning before sufficient contrast reaches the aorta. The arterial phase may be optimized with the use of fluoroscopic triggering (1), an automated bolus detection technique (2), a timing run (3), or a "best-guess" method. With improved gradient strength, pulse sequences, and parallel imaging methods, a "time-resolved" approach can also be used, which will obviate the need for a timing strategy (4). Scanning with rapid temporal resolution (approxi...

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Renal Lymphoma: CT Patterns with Emphasis on Helical CT

Cited by 160 publications

References 33 publications

Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3−/− mice

Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3−/− mice

Burkitt Lymphoma: Involvement of Both Ovaries and Kidneys in an Adult: Case Report

MRI of the kidney and urinary tract

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