Bilateral Ovarian Metastasis from Left Renal Cell Carcinoma

Sasagawa, Isoji; Nakada, Teruhiro; Saitoh, Masaaki; Mitobe, Katuyuki; Ohta, Tukasa; Tanaka, Mikio

doi:10.1159/000282600

Cited by 14 publications

(10 citation statements)

References 5 publications

(6 reference statements)

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“…Renal cell carcinoma also has the potential to metastasize to the ovaries (Liu et al, 1992;Young and Hart, 1992;Spencer et al, 1993;Adachi et al, 1994;Hammock et al, 2003;Insabato et al, 2003;Anagnostou et al, 2009), as has transitional cell carcinoma of the urinary tract (Fossa et al, 1977;Hsiu et al, 1991;Oliva et al, 1995) and other urinary tract tumours (Gadd et al, 1960).…”

Section: Tumours Of the Urinary Tractmentioning

confidence: 99%

Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review

Bastings

Beerendonk

Westphal

et al. 2013

Human Reproduction Update

191

105

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BACKGROUND The risk of recurrent oncological disease due to the reintroduction of cancer cells via autotransplantation of cryopreserved ovarian tissue is unknown. METHODS A systematic review of literature derived from MEDLINE, EMBASE and the Cochrane Library was conducted. Studies on follow-up after autotransplantation; detection of cancer cells in ovarian tissue from oncological patients by histology, polymerase chain reaction or xenotransplantation; and epidemiological data on ovarian metastases were included. RESULTS A total of 289 studies were included. Metastases were repeatedly detected in ovarian tissue obtained for cryopreservation purposes from patients with leukaemia, as well as in one patient with Ewing sarcoma. No metastases were detected in ovarian tissue from lymphoma and breast cancer patients who had their ovarian tissue cryopreserved. Clinical studies indicated that one should be concerned about autotransplantation safety in patients with colorectal, gastric and endometrial cancer. For patients with low-stage cervical carcinoma, clinical data were relatively reassuring, but studies focused on the detection of metastases were scarce. Oncological recurrence has been described in one survivor of cervical cancer and one survivor of breast cancer who had their ovarian tissue autotransplanted, although these recurrences may not be related to the transplantation. CONCLUSIONS It is advisable to refrain from ovarian tissue autotransplantation in survivors of leukaemia. With survivors of all other malignancies, current knowledge regarding the safety of autotransplantation should be discussed. The most reassuring data regarding autotransplantation safety were found for lymphoma patients.

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Section: Tumours Of the Urinary Tractmentioning

confidence: 99%

Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review

Bastings

Beerendonk

Westphal

et al. 2013

Human Reproduction Update

191

105

View full text Add to dashboard Cite

show abstract

“…The distinction of an ovarian primary tumor from metastatic RCC can be difficult, especially when the ovarian metastasis is discovered first and mimics a primary ovarian clear cell carcinoma. To the best of our knowledge 11 cases of clinically detected ovarian metastatic tumor of RCC have been reported in detail [3][4][5][6][7]. We present here the clinicopathologic findings of 3 new cases found in the files of our Department from 1985 to 2000.…”

mentioning

confidence: 96%

Ovarian Metastasis from Renal Cell Carcinoma: A Report of Three Cases

Insabato

Rosa²,

Franco³

et al. 2003

Int J Surg Pathol

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Ovarian metastases from renal cell carcinoma (RCC) are very rare. Over the past 16 years we have encountered 3 examples. The first 2 cases occurred in adults 49 and 50 years old, respectively, who had huge ovarian metastases, clinically detected 12 and 14 months, respectively, after diagnosis of RCC. The third case was a 17-year-old girl in whom a metastatic renal cell carcinoma was detected in an otherwise benign-appearing cystic ovarian mass. To the best of our knowledge only 11 cases of clinically detected ovarian metastases of RCC have been reported. We report 3 new cases and review the literature on the subject.

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“…Drug treatment after the finding of adnexal metastases was administered only in two of the literature reports [3,4]; an inhibitor of cell proliferation (interferon alpha) was used in both cases. Survival does not significantly change in treated versus untreated patients (35 versus 26 months).…”

Section: Discussionmentioning

confidence: 99%

Bilateral metachronous ovarian metastases from clear cell renal carcinoma: a case report

2009

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IntroductionBilateral ovarian metastases from a clear cell renal carcinoma are uncommon findings and need to be differentiated from primary cancers. Diagnostic imaging and histopathological features are often inconclusive, unless they are combined.Case presentationA 56-year-old woman with a history of right radical nephrectomy for a renal clear cell carcinoma diagnosed 10 years earlier was referred for abdominal distension and pelvic pain. Color-Doppler US and Computer Tomography scan revealed the presence of bilateral ovarian masses with regular margins, a low resistance index and poor contrast enhancement. Immunohistochemistry showed positive epithelial membrane antigen, cytokeratin, vimentin and CD10, suggesting clear cells from the previously diagnosed kidney cancer.ConclusionAlthough bilateral metachronous ovarian metastases from clear cell renal carcinoma are a very uncommon finding, they can be considered in the differential diagnosis and investigated with imaging and immunohistochemistry. The 6 cases reported in the literature indicate a good prognosis for this condition.

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Bilateral Ovarian Metastasis from Left Renal Cell Carcinoma

Abstract: We report a case of left renal cell carcinoma with bilateral ovarian metastasis which was demonstrated 3 years after radical nephrectomy. The patient is alive without any evidence of disease 36 months after bilateral salpingooophorectomy.

Cited by 14 publications

References 5 publications

Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review

Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review

Ovarian Metastasis from Renal Cell Carcinoma: A Report of Three Cases

Bilateral metachronous ovarian metastases from clear cell renal carcinoma: a case report

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