Ovarian Metastasis from Renal Cell Carcinoma: A Report of Three Cases

Abstract

Ovarian metastases from renal cell carcinoma (RCC) are very rare. Over the past 16 years we have encountered 3 examples. The first 2 cases occurred in adults 49 and 50 years old, respectively, who had huge ovarian metastases, clinically detected 12 and 14 months, respectively, after diagnosis of RCC. The third case was a 17-year-old girl in whom a metastatic renal cell carcinoma was detected in an otherwise benign-appearing cystic ovarian mass. To the best of our knowledge only 11 cases of clinically detected ovarian metastases of RCC have been reported. We report 3 new cases and review the literature on the subject.

Ovarian metastasis of clear cell renal cell carcinoma: A case report

“…12,13 Moreover, metastasis of clear cell carcinoma from other primary sites, including the kidney, should also be considered. The presence of hobnail cells and extracellular mucin are more typical of clear cell carcinoma of the ovary, while a solid and tubular growth pattern with bland cells and a prominent vascular network raises the possibility of a metastasis of clear cell RCC.…”

Ovarian metastasis after radical nephrectomy for primary renal clear cell carcinoma: a diagnostic challenge

“…Hammock et al and Insabato et al detailed and reviewed the differential diagnoses for primary ovarian clear cell tumors that should be distinguished from RCC metastasis: primary clear cell carcinoma, steroid cell tumors, and dysgerminoma [8,11]. Because metastasis of RCC can mimic these entities, they concluded that immunohistochemical testing is necessary to differentiate primary ovarian lesions from RCC metastasis.…”

Right Sited Renal Cell Carcinoma Metastasizing to the Contralateral Ovary: Case Report and Review of the Literature

“…This may be attributed to ovarian atrophy and decreased blood perfusion due to vascular sclerosis in most postmenopausal women who are at the age of peak incidence of RCC. The 22 relevant cases [3][4][5][6][7][8][9][10][11][12][13] are analyzed including the present case and summarized in Table 1.…”

“…Information on long term survival was limited. However, in well documented cases overall survival ranged from 3 months to 16 years [3][4][5][7][8][9][10][11][12][13].…”