Bilateral Ovarian Metastases from Renal Clear Cell Carcinoma

Vara, Alejandro; Madrigal, B; Veiga, Manuel; Díaz, Ana Carolina; García, Juan de Dios; Calvo, Juan

doi:10.1080/028418698430610

Cited by 18 publications

(15 citation statements)

References 5 publications

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“…However, certain histological and ultra structural features may help to establish the correct diagnosis. The presence of clear cells with some areas showing a tubulocystic pattern with the characteristic “hob-nail” appearance of the lining epithelium and extra cellular mucin are more typical of clear cell carcinoma of the ovary [7-9]. While clear RCC are round to ovoid and circumscribed by a psuedocapsule of compressed parenchyma and fibrous tissue, rather than a true capsule, they are also hypervascular [10].…”

Section: Discussionmentioning

confidence: 99%

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Renal cell carcinoma metastasis to the ovary: a case report

Toquero

Aboumarzouk

Abbasi

2009

Cases J

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A 54-year-old woman referred to a specialist unit for weight loss, lethargy, and a palpable pelvic mass. Thought to have ovarian cancer metastasized to the kidney, underwent a left nephrectomy and para-aortic clearance, with a total abdominal hysterectomy and bilateral salpingo-oophorectomy with peritoneal biopsies. Histology proved it was actually a renal cell carcinoma metastasized to the ovaries. During further follow ups she had developed bone and pulmonary metastasis and died shortly after the diagnosis of metastasis. With only 14 reported cases in the literature increased awareness would aid management of similar cases.

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Section: Discussionmentioning

confidence: 99%

“…While clear RCC are round to ovoid and circumscribed by a psuedocapsule of compressed parenchyma and fibrous tissue, rather than a true capsule, they are also hypervascular [10]. The cells also contain numerous lipid vacuoles and long slender microvilli and lack rough endoplasmic reticulum [7-9]. …”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma metastasis to the ovary: a case report

Toquero

Aboumarzouk

Abbasi

2009

Cases J

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“…In the literature there are 19 cases of renal clear cell carcinoma metastasized to the ovaries, 5 of which are bilateral and metachronous [1-5]. …”

Section: Discussionmentioning

confidence: 99%

“…Ovarian metastases from a renal clear cell carcinoma are uncommon events, which has been described in 19 case reports [1-6]. Some of these secondary lesions are metachronous to the primary tumor, and the vast majority is monolateral [6].…”

Section: Introductionmentioning

confidence: 99%

Bilateral metachronous ovarian metastases from clear cell renal carcinoma: a case report

2009

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IntroductionBilateral ovarian metastases from a clear cell renal carcinoma are uncommon findings and need to be differentiated from primary cancers. Diagnostic imaging and histopathological features are often inconclusive, unless they are combined.Case presentationA 56-year-old woman with a history of right radical nephrectomy for a renal clear cell carcinoma diagnosed 10 years earlier was referred for abdominal distension and pelvic pain. Color-Doppler US and Computer Tomography scan revealed the presence of bilateral ovarian masses with regular margins, a low resistance index and poor contrast enhancement. Immunohistochemistry showed positive epithelial membrane antigen, cytokeratin, vimentin and CD10, suggesting clear cells from the previously diagnosed kidney cancer.ConclusionAlthough bilateral metachronous ovarian metastases from clear cell renal carcinoma are a very uncommon finding, they can be considered in the differential diagnosis and investigated with imaging and immunohistochemistry. The 6 cases reported in the literature indicate a good prognosis for this condition.

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“…They are thought to be of mesonephric origin and can be misinterpreted as malignant neoplasms 5,6. Bilateral metastatic renal carcinoma to the ovary is rare7 and has not been reported in patients with von Hippel-Lindau, but it can be mistaken for primary ovarian tumors. We report the first two cases of testosterone-secreting lipid cell tumors of the ovary in von Hippel-Lindau syndrome.…”

Section: Commentmentioning

confidence: 99%