Bilateral ovarian endometriomas after laparoscopic hysterectomy following adjuvant tamoxifen therapy for breast cancer: A case report

Nishiyama, Satoshi; Hayashi, Sotaro; Abe, Naoki; Kira, Sachino; Oda, Mayumi; Lee, Lifa; To, Yoko; Goto, Maki; Tsujioka, Hiroshi

doi:10.1016/j.crwh.2022.e00442

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…1, have demonstrated remarkable pharmacological properties, including anti-diabetic, antiviral, antidepressant, antiarrhythmic, anticancer and antifungal activities. [7][8][9][10][11][12] However, the piperazine ring is a common heterocyclic structural element utilized in drug design to enhance the aqueous solubility of molecules. 13 It is frequently encountered in kinase inhibitors such as Imatinib and Bosutinib, both of which act as BCR-ABL inhibitors.…”

Section: Introductionmentioning

confidence: 99%

“…These compounds, exemplified in Fig. 1, have demonstrated remarkable pharmacological properties, including anti‐diabetic, antiviral, antidepressant, antiarrhythmic, anticancer and antifungal activities 7–12 . However, the piperazine ring is a common heterocyclic structural element utilized in drug design to enhance the aqueous solubility of molecules 13 .…”

Section: Introductionmentioning

confidence: 99%

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Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

Wang,

Li,

Zhu

et al. 2024

Pest Management Science

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BACKGROUNDXanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant yield and cost losses in rice. In this study, a series of novel derivatives containing the isopropanolamine moiety linked to various substituted phenols and piperazines were designed, synthesized and screened.RESULTSAntibacterial activity results showed that most compounds had good inhibitory effects on Xoo, among which compound W2 (EC50 = 2.74 μg mL−1) exhibited the most excellent inhibitory activity, and W2 also had a certain curative effect (35.89%) on rice compared to thiodiazole copper (TC) (21.57%). Scanning electron microscopy (SEM) results indicated that compound W2 could cause rupture of the Xoo cell membrane. Subsequently, proteomics and quantitative real‐time polymerase chain reaction revealed that compound W2 affected the physiological processes of Xoo and may exert antibacterial activity by targeting the two‐component system pathway. Interestingly, W2 upregulated Xoo's methyltransferase to impact on its pathogenicity.CONCLUSIONThe present study offers a promising phenolic‐piperazine‐sopropanolamine compound as an innovative antibacterial strategy by specifically targeting the two‐component system pathway and inducing upregulation of methyltransferase to effectively impact Xoo's pathogenicity. © 2024 Society of Chemical Industry.

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