Bilateral, multicentric low-grade adenosquamous carcinomas of the breast, each arising within a separate radial scar/complex sclerosing lesion

Wilsher, Mark James; Snook, Kylie

doi:10.1097/pat.0000000000000034

Cited by 11 publications

(23 citation statements)

References 7 publications

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“…In late radial scars these are not described, the assumption being that they regress over time. 8 These cases illustrate the fact that the distinction between RSL with prominent ASP and LGASC is subjective and, moreover, is probably artificial. More recently, a case of bilateral RSL with prominent ASP regarded as multiple LGASC was also reported.…”

Section: Introductionmentioning

confidence: 95%

Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?

Wilsher

2014

Pathology

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Section: Introductionmentioning

confidence: 95%

Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?

Wilsher

2014

Pathology

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“…It is rare and an unusual primary breast malignancy. Cytological examples are rare and only 7 cases have been reported in the English literature [3,4,5,6,7,8,9]. Analysis of all 7 previously published cases, and our 3 cases, shows that patients were predominantly postmenopausal and their age ranged from 45 to 81 years (mean 59; median 57).…”

Section: Discussionmentioning

confidence: 99%

“…One case was incorrectly diagnosed on frozen sections and the other was incorrectly diagnosed using core-needle biopsy. Literature data also show diagnostic difficulties, since 1 case was also underdiagnosed as ‘complex sclerosing lesion' [9]. …”

Section: Discussionmentioning

confidence: 99%

“…Since the initial report of LGASC in 1912 [2], approximately 120 new cases have been studied by histopathology and only 7 cases by cytology [3,4,5,6,7,8,9]. The difficulty to obtain a cytological diagnosis of malignancy is mainly due to the absence of standard cytological features of malignancy, resulting in resemblance to benign breast lesions.…”

Section: Introductionmentioning

confidence: 99%

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Fine-Needle Aspiration of Low-Grade Adenosquamous Carcinomas of the Breast: A Report of Three New Cases

Bataillon

Collet²,

Voillemot³

et al. 2014

Acta Cytologica

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Objectives: To describe cytology patterns in low-grade adenosquamous carcinomas (LGASCs) of the breast. Study Design: Low-grade adenosquamous carcinomas of the breast are a recently described rare variant of primary metaplastic carcinomas characterized by clinical indolence, slow evolution and excellent survival. To date, only 7 cases of LGASC were studied cytologically, and it was demonstrated that LGASC identification was difficult because its cellular components exhibited unspecific and nonsuspicious features. They consisted of irregularly clustered cells without prominent cytonuclear atypia, mitosis or necrosis. The presence of metaplastic cells or keratin debris was helpful in accurate tumor typing. We report here 3 additional cases of LGASC that were initially studied by fine-needle aspiration. Results: We have also encountered diagnostic difficulties and misdiagnosed tumors, since 2 cases were underdiagnosed as ‘suspicious' and only 1 was accurately diagnosed as malignancy. Conclusion: The review of our cases and the literature confirms that, despite its putative metaplastic origin, LGASC is an entity which is difficult to diagnose using classical cytological methods. Moreover, core-needle biopsy as well as frozen sections may also misdiagnose LGASC as a benign breast lesion.

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“…17 -19 Rarely, the tumours may be multiple. 21 Metaplastic carcinoma with (heterologous) mesenchymal differentiation…”

Section: Low-grade Adenosquamous Carcinomamentioning

confidence: 99%

Mesenchymal tumours of the breast and their mimics: a review with approach to diagnosis

2016

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Bilateral, multicentric low-grade adenosquamous carcinomas of the breast, each arising within a separate radial scar/complex sclerosing lesion

Cited by 11 publications

References 7 publications

Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?

Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?

Fine-Needle Aspiration of Low-Grade Adenosquamous Carcinomas of the Breast: A Report of Three New Cases

Mesenchymal tumours of the breast and their mimics: a review with approach to diagnosis

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