Bilateral hand transplantation: Bone healing under immunosuppression with tacrolimus, mycophenolate mofetil, and prednisolone

Gabl, M.; Pechlaner, S.; Lutz, M.; Bodner, Gerd; Piza, Hildegunde; Margreiter, Raimund

doi:10.1016/j.jhsa.2004.05.007

Cited by 21 publications

(13 citation statements)

References 31 publications

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“…2,6,13,37 Subsequently, all hand and finger flexor and extensor tendons were attached. The ulnar and Scale to measure potential posttransplant effects (eg, adherence, responsibility) median nerve were coapted thereafter.…”

Section: Surgerymentioning

confidence: 99%

“…As reported for patient 1, bone healing after hand transplantation was not influenced or altered by immunosuppression, compared with replantation. 37,38 Vascular invasion and callus formation appeared at week 3, calcified callus was observed at 4 months after transplantation, and bone union was completed after 11 months. In patient 2, the right forearm flexors revealed signs of fibrosis and ossification, resulting in dissection of this small compartment.…”

Section: Graft Monitoringmentioning

confidence: 99%

See 1 more Smart Citation

World Experience After More Than a Decade of Clinical Hand Transplantation: Update on the Innsbruck Program

et al. 2011

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Section: Surgerymentioning

confidence: 99%

Section: Graft Monitoringmentioning

confidence: 99%

World Experience After More Than a Decade of Clinical Hand Transplantation: Update on the Innsbruck Program

et al. 2011

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“…Er trug 5 Jahre myoelektrische Prothesen, die ihm die R ü ckkehr in den Beruf als Polizist im Innendienst erm ö glichten. Ü ber technische Details, Knochenheilung und Ergebnisse wurde berichtet [15,42,44] . Der Patient wurde bereits pr ä operativ angewiesen seine (bis dahin noch nicht vorhandenen) Finger und das Handgelenk durch Imagination anzusteuern und zu bewegen.…”

Section: Fallunclassified

Zehn Jahre Handtransplantation Experiment oder Routine?

Piza‐Katzer¹,

Wechselberger²,

Estermann³

et al. 2009

Handchir Mikrochir plast Chir

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In the 20th century the legend of Cosmas and Damian - an extremity being transferred from one person to another - became reality. The first hand transplantation was carried out in 1964 in Ecuador but the hand had to be removed again within three weeks due to rejection. Although he was the first one to be treated with more modern immunosuppressants, the same fate overtook another patient who received a hand from a brain-dead donor in 1998 in Lyon. Since then only 32 persons worldwide have been provided with parts of the upper extremity. The partly published histories of three patients who have had both hands transplanted will be summarised and indication critically assessed once again. It is also stressed how difficult, multi-layered and complex the patient's education is. The patient has to be informed in many conversations beforehand about every stage of therapy but also about possible complications and even rejection. Can the psychological burden/stress while waiting for a donor, the difficult post-operative period, lifelong adherence to a rigorous drug-regimen, the complexity of the whole procedure be made comprehensible to a layman? To replace same with same is the goal of the best-possible reconstructive surgery. It is to hope that through future innovations in the immunosuppressing therapy patients can be offered transplantation of one or both hands as a routine-operation. Until then indication has to be strict and the operation can possibly only be performed in a few centres. Long-time prospects, disadvantages and complications, as well as side effects have to be presented openly.

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“…Interessan terweise führen sowohl Cyclosporin als auch Tacrolimus zu einer verbesserten axonalen Regeneration [1], was vor dem Hintergrund beispielsweise einer Ober armtransplantation als günstig zu bewer ten ist. Tacrolimus kann dabei die Synthe se des "axotomyinduced growthassocia ted proteins" (GAP43) [11,12] und die os teoblastische Differenzierung über Induk tion von "bone morphogenic protein4" steigern [9].…”

Section: Introductionunclassified

Organtransplantation, Gewebetransplantation und plastische Chirurgie

2010

J. f. Ästhet. Chirurgie

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Bilateral hand transplantation: Bone healing under immunosuppression with tacrolimus, mycophenolate mofetil, and prednisolone

Cited by 21 publications

References 31 publications

World Experience After More Than a Decade of Clinical Hand Transplantation: Update on the Innsbruck Program

World Experience After More Than a Decade of Clinical Hand Transplantation: Update on the Innsbruck Program

Zehn Jahre Handtransplantation Experiment oder Routine?

Organtransplantation, Gewebetransplantation und plastische Chirurgie

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