World Experience After More Than a Decade of Clinical Hand Transplantation: Update on the Innsbruck Program

Hautz, Theresa; Engelhardt, Timm Oliver; Weißenbacher, Annemarie; Kumnig, Martin; Zelger, Bettina; Rieger, Michael; Rumpold, Gerhard; Pierer, Gerhard; Ninković, Marina; Gabl, M.; Piza‐Katzer, Hildegunde; Pratschke, Johann; Margreiter, Raimund; Brandacher, Gerald; Schneeberger, Stefan

doi:10.1016/j.hcl.2011.07.004

Cited by 71 publications

(56 citation statements)

References 35 publications

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“…[3][4][5] From the present data, it is clear that hands can be transplanted with a high probability of long-term allograft survival. [6][7][8][9][10][11][12][13]15 It should be noted that neither the surgical procedure nor the use of immunosuppression represents a marked change. Replantation of the hand, and use of immunosuppression in solid organ transplantation, are the standards of care in their respective fields.…”

Section: Discussionmentioning

confidence: 99%

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A Methodology for Determining Standard of Care Status for a New Surgical Procedure

Breidenbach

Meister

Türker

et al. 2016

Plastic and Reconstructive Surgery

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Section: Discussionmentioning

confidence: 99%

“…21,25,26 There is a record of success that is far beyond what was anticipated. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Hand transplant function is superior to hook or myoelectric prosthesis. 27 Hand transplant survival is superior to solid organ transplantation.…”

Section: Discussionmentioning

confidence: 99%

A Methodology for Determining Standard of Care Status for a New Surgical Procedure

Breidenbach

Meister

Türker

et al. 2016

Plastic and Reconstructive Surgery

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“…Hautz and colleagues reported reperfusion within 4 hours for all transplants, including bilateral cases. 20 If the location of the donor will allow for ischemia time to remain under the suggested 8-10 hours, further analysis of the physical characteristics and quality of the donor upper extremities is indicated.…”

Section: Practical Considerationsmentioning

confidence: 99%

Surgical and Logistical Aspects of Donor Limb Procurement in Hand and Upper Extremity Transplantation

Hausien

Swanson

Abraham

et al. 2014

Vascularized Composite Allotransplantation

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Hand and upper extremity transplantation offers a promising reconstructive solution for select patients lacking a functional upper limb. For such an endeavor, it is imperative that multiple medical and surgical specialties and teams work in concert to achieve a common goal. Sixteen years from the first successful hand transplantation, the number of centers performing or planning to perform hand transplantation worldwide has increased considerably. This procedure may become the standard of care for properly selected patients in the not-too-distant future. To facilitate this transition, unified protocols are required. In this manuscript, we focus on the donor limb procurement process, including the sequence of events, logistics, and inter-specialty team interaction. Through review of the current literature, we acknowledge and address possible variations, and provide an illustrative overview of the operation. It is important that all members involved in this procedure, including the Organ Procurement Organization (OPO), solid organ procurement teams, and donor hospital staff, are aware of this process. Opportunities for future research in this field are further discussed.

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“…[6][7][8][9][10][11][12][13][14][15][16][17] Though it offers sensation, function, cosmetic, and psychological benefits, there are significant risks associated with the lifelong immunosuppressive medication required with transplantation. 4,5,7,12,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] This article aims to outline the challenges of hand transplantation by discussing patient selection, effect on quality of life, financial burden, functional outcomes, and risks of immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

Hand transplantation: current challenges and future prospects

Alolabi¹,

Augustine²,

Thoma³

2017

TRRM

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Over the last two decades, 113 vascularized composite allotransplantation (VCA) of the hand have been performed in 76 patients globally. The procedure that was once regarded as experimental has certainly emerged as a clinical reality with multiple centers worldwide now performing it. The psychological and physical impact of losing an upper extremity is profound. Amputees face significant challenges contributing to disability and dependence even with activities of daily living. Hand transplantation offers functions with restoring sensation, voluntary motor control, and proprioception, as well as a sense of feeling "whole" again. Along with these benefits, however, transplantation carries a significant risk profile attributed to the complications of life-long immunosuppression and possible rejection. Moreover, the procedure carries a significant financial burden to the health care system. As hand VCA is becoming more widely accepted and performed worldwide, there are still many challenges that will face its rapid growth. This review highlights some of the challenges facing hand VCA including patient selection, effect on quality of life, financial burden, functional outcomes, and complications of immunosuppression.

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World Experience After More Than a Decade of Clinical Hand Transplantation: Update on the Innsbruck Program

Cited by 71 publications

References 35 publications

A Methodology for Determining Standard of Care Status for a New Surgical Procedure

A Methodology for Determining Standard of Care Status for a New Surgical Procedure

Surgical and Logistical Aspects of Donor Limb Procurement in Hand and Upper Extremity Transplantation

Hand transplantation: current challenges and future prospects

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