Bilateral epibulbar granulocytic sarcomas: a case of an 8-year-old girl with acute myeloid leukaemia

Rosenberg, Caroline; Finger, Paul T.; Furlan, Louis; Iacob, Codrin

doi:10.1007/s00417-006-0341-3

Cited by 14 publications

(4 citation statements)

References 10 publications

(20 reference statements)

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“…[5][6][7] There is a tendency for it to develop in the orbits of children, arising from the adjacent orbital bones, whereas the cases which prove to be initial manifestations of pediatric AML are not uncommon. 7,8 Conjunctival 9-11 or eyelid involvement is even rarer, 12 an aleukemic case of which has only been reported once.…”

Section: Discussionmentioning

confidence: 94%

Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course

Iliadis

Κoletsa

Georgiou

et al. 2016

The American Journal of Dermatopathology

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Leukemic infiltrates may be seen in the skin in the absence of detectable bone marrow involvement. Leukemia cutis may exceptionally occupy the eyelids. An unusual case of a 58-year-old man presenting bilateral erythematous eyelid lesions, proven to be aleukemic leukemia cutis, is reported. Biopsy was conducted and hematoxylin/eosin stained sections were histologically evaluated. Immunohistochemistry was also performed.Light microscopy revealed cutaneous infiltration by a neoplastic population consisting of medium-sized cells. These cells infiltrated the overlying epidermis leading to focal microulcerations. The morphological and immunohistochemical characteristics of the neoplastic population were compatible with myeloid leukemia cutis. The bone marrow biopsy was normocellular for the patient's age. Although chemotherapy was advised, the patient refused any treatment. He remains free of leukemia or evolution of eyelid lesions approximately 1 year after diagnosis. Leukemia cutis of the eyelids is a rare manifestation of acute leukemia and may remain aleukemic in adults for an indefinite period of time.

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Section: Discussionmentioning

confidence: 94%

Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course

Iliadis

Κoletsa

Georgiou

et al. 2016

The American Journal of Dermatopathology

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“… 37 Even with appropriate treatment, conjunctival granulocytic sarcoma has been associated with a poor prognosis. 49 One case of bilateral subconjunctival hemorrhage in an infant as an initial AML manifestation has also been reported. 51 …”

Section: Methodsmentioning

confidence: 98%

“… 43 Studies have found that extramedullary involvement in general, and conjunctival leukemic infiltrates in particular, were more common in myelomonocytic and monocytic leukemia than other forms of AML. 49 Many authors suggested chemotherapy as the treatment of choice 50 while others advocate local radiotherapy. 37 Even with appropriate treatment, conjunctival granulocytic sarcoma has been associated with a poor prognosis.…”

Section: Methodsmentioning

confidence: 99%

Early Ophthalmological Manifestations of Acute Myeloid Leukemia: Current Perspectives

Salloukh¹,

Hage²,

Bashshur³

et al. 2022

OPTH

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Acute myeloid leukemia (AML) is a hematological malignancy affecting different organ systems including the eye. The purpose of this review is to present and evaluate the medical literature regarding the early ophthalmological manifestations of acute myeloid leukemia. AML affects the ocular system through direct infiltration of tissues, secondary to hematological abnormalities, or in the form of chloroma or myeloid sarcoma in the brain or orbit consequently leading to a variety of manifestations depending on the ocular tissue involved. It is imperative for ophthalmologists to be aware of the early ophthalmological manifestations of AML which will allow for earlier diagnosis and treatment of this life-threatening disease.

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“…This case is different from most other conjunctival myeloid sarcomas in that it arose in a chronic myeloproliferation rather than in an acute one. Another conjunctival example was reported in an 8-year-old girl with bilateral epibulbar myeloid sarcomas [10]. A unique presentation occurred in a 34-year-old apparently healthy woman who displayed involvement of the palpebral conjunctiva of all 4 eyelids with red, papular lesions [11].…”

Section: Discussionmentioning

confidence: 99%

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva

2018

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An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Forty percent of the neoplastic cells were Ki-67 positive. Cytogenetic studies indicated a trisomy 8 (associated with worse prognosis) and a t(12; 17) translocation. Desmin, smooth muscle actin, pancytokeratin, CAM 5.2, adipophilin, tryptase, S100, SOX10, MART1, and E-cadherin were negative, ruling out a nonhematopoietic tumor. The conjunctival lesion was diagnosed as a myeloid sarcoma with megakaryoblastic differentiation, a rare variant. It probably arose from a myelodysplastic syndrome. This is the first case of its type to develop in the conjunctiva.

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Bilateral epibulbar granulocytic sarcomas: a case of an 8-year-old girl with acute myeloid leukaemia

Abstract: Epibulbar granulocytic sarcoma in AML is rare (particularly in a child). We describe the first high-frequency ultrasound images and illustrate the use of a minimally invasive fine-needle aspiration biopsy technique to confirm our diagnosis.

Cited by 14 publications

References 10 publications

Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course

Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course

Early Ophthalmological Manifestations of Acute Myeloid Leukemia: Current Perspectives

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva

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