Bilateral Effects of Vaccination Against Infectious Bursal Disease and Newcastle Disease in Specific Pathogen-Free Layers and Commercial Broiler Chickens

Rautenschlein, Silke; Kraemer, Christian; Montiel, Enrique; Vanmarcke, Johan; Haase, Christine

doi:10.1637/1933-5334(2007)2[e3:beovai]2.0.co;2

Cited by 4 publications

(6 citation statements)

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“…There are studies which demonstrate, to a certain degree of certitude, the existence of some connections between IBDV–induction of immunosuppression and the severe injuries which appear in bursa of Fabricius. Even more, there have been situations, even as hypothesis, of association of IBDV with B cells, macrophages and follicular dendritic cells in bursa and spleen [ 8 ]. Other fundamental studies mention that these IBD–AB vaccines may induce suppressive secondary effects in the immune system, such as systemic T cell activity.…”

Section: Resultsmentioning

confidence: 99%

“…Infectious bursal disease virus (IBDV) causes clinical disease of considerable economic importance in chickens, usually between 3 and 6 weeks of age or possibly older, following infection with very virulent strains. Numerous vaccines and vaccination programs have been studied and proposed worldwide [ 6 – 8 ]. The effect of polysaccharides present in EF extracts from the edible mushroom P. ostreatus are investigated here with emphasis on the specific response of the chickens’ immunitary system.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus

Selegean

Putz

Rugea³

2009

IJMS

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The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers’ survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus

Selegean

Putz

Rugea³

2009

IJMS

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“…Despite the high bursa lesion scores and the possibility of at least a temporary immunosuppression due to the IBDV vaccination (Kim et al, 1999;Sharma et al, 2000;Rautenschlein et al, 2007), the performance of the broiler flocks was not affected. All flocks had production indices that coincided with field experiences.…”

Section: Discussionmentioning

confidence: 97%

A field study on the significance of vaccination against infectious bursal disease virus (IBDV) at the optimal time point in broiler flocks with maternally derived IBDV antibodies

et al. 2007

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The right strategy for infectious bursal disease (IBD) control and its success rate under field conditions depends on hygiene management, IBD field pressure, level and variation in maternally derived IBD antibodies, and the IBD vaccine strains to be used. Usually, standard vaccination programmes are used, which are not always adapted to the specific conditions on the farm and to the immune status of chickens. Employing the ''Deventer formula'' may help to estimate the optimal time for vaccination for a specific flock based on the maternally derived antibody level, its variation, the genetic background of the chicken, and the IBD vaccine strain. Two field studies with 16 or 20 commercial broiler flocks were conducted, applying an intermediate IBD vaccine before, at the best, and after the estimated optimal vaccination time estimated by the ''Deventer formula''. These studies showed that flocks IBD-vaccinated between 1 day before, at, or up to 3 days after the estimated optimal time point developed detectable humoral immunity up to 14 days post vaccination. If birds had been vaccinated more than 1 day before the calculated optimal vaccination date, the humoral immune response was delayed or non-detectable until slaughter. The induction of humoral immunity correlated with the incidence of bursa lesions and IBDV detection by reverse transcriptase-polymerase chain reaction. As indicated in this study, under field conditions bursa lesions may develop later than predicted based on experimental experiences. The late incidence of bursa lesions after vaccination may be confused with field virus-induced lesions, in which case sequencing may offer a valuable tool for differentiation.

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“…On the contrary, chicks vaccinated with ordinary and over vaccine doses (groups 2 and 3) exhibited significant immunosuppression, as evidenced by the decrease in ND antibody response. The difference in immune response observed between the ND and AI vaccines may be attributed to the time interval passing between the administration of these vaccines relative to the IBD vaccines (Ali et al, 2004) as intermediate vaccines cause transient immunosuppression to ND vaccine in SPF chicks (Rautenschlein et al, 2007). A similar response to the ND vaccine in SPF chicks was recorded by (Coletti et al, 2001) after in ovo vaccination with D78, while no immunosuppressive effect was recorded in commercial chicks receiving the same vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…Also, no immunosuppressive effect toward the ND vaccine was observed by Abaza et al, (2020) after intra-cloacal inoculation of the ordinary dose of the D78 vaccine in commercial chicks. This may be attributed to the difference in genetic backgrounds of the breeds and interference of MDA (Rautenschlein et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Comparative Immunopathological Study of Various Intra-Cloacal Infectious Bursal Disease Vaccine Doses.

Abaza

ElBorai

Eissa

et al. 2020

Benha Veterinary Medical Journal

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Infectious bursal disease (IBD) is a contagious immunosuppressive viral infection of young chickens. Intra-cloacal approach is effective for vaccinating chicks with high maternally derived IBD antibodies; however, the vaccinal traditional dose may be unsuitable for this route. A total of 60 one-day-old specific-pathogen-free (SPF) chicks were randomly distributed into four groups. Group-1: was control and chicks in group-2: were vaccinated with 10 3.5 TCID50 of D78 strain/ bird via intra-cloacal route, chicks in group-3: were vaccinated with a ten-fold higher dose (10 4.5 TCID50/bird) and chicks in group-4: were vaccinated with a dose of 10 2.5 TCID50 of D78 strain/bird using same approach. IBD antibody titers were measured at the 14 th and 21 st days of age. The immunosuppressive effects of different doses were determined through humoral immune response to avian influenza and Newcastle disease vaccines, the relative weight of primary lymphoid organs, and histopathologically evaluated bursal lesions. The results indicated that a dose even ten-fold higher than the usual dose to SPF chicks via intra-cloacal route caused neither morbidity nor mortality. All vaccine doses induced potent immune responses against IBD, but the highest IBD antibodies titers were observed in group-4 while IBD antibodies titers were decreased with increasing vaccine doses in other experimental groups. Even the vaccinated birds showed moderate histopathological lesions and the diminutive relative weight of bursae; there was no immunosuppressive effect in the immune response to other vaccines in group-4 and transient immunosuppressive effect in groups-2 and-3. All that proves the safety and effectiveness of various intra-cloacal vaccination approach doses.

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Bilateral Effects of Vaccination Against Infectious Bursal Disease and Newcastle Disease in Specific Pathogen-Free Layers and Commercial Broiler Chickens

Cited by 4 publications

References 0 publications

Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus

Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus

A field study on the significance of vaccination against infectious bursal disease virus (IBDV) at the optimal time point in broiler flocks with maternally derived IBDV antibodies

Comparative Immunopathological Study of Various Intra-Cloacal Infectious Bursal Disease Vaccine Doses.

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