Bilateral choroidal metastases secondary to uterocervical carcinoma of the squamous cell type

Inoue, Kenji; Numaga, Jiro; Kaji, Yuichi; Toda, Junko; Kato, Satoshi; Sakurai, Masaki; Ikeda, Makoto; Motoi, Noriko; Murakami, Toshikazu; Fujino, Yujiro

doi:10.1016/s0002-9394(00)00590-0

Cited by 14 publications

(18 citation statements)

References 3 publications

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“…External beam radiotherapy can be used to improve visual function in this setting, as with other cases of choroidal metastasis [4]. Combined radiotherapy and chemotherapy (usually cisplatin-based) may improve life expectancy.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of choroidal metastases arise from breast malignancies in women and lung malignancies in men; less common sites of primary malignancy include the gastrointestinal tract, prostate, and kidney [1]. Choroidal metastasis secondary to cervical squamous cell carcinoma (SCC) is extremely rare [1, 3], with only 3 cases previously reported [2, 4, 5]. The current case is unique in the fact that it resulted in bilateral loss of vision and that there was no prior knowledge of the primary malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss

Shibeeb

Athanasiov

Simon

et al. 2014

Case Reports in Ophthalmological Medicine

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We report a patient with bilateral choroidal metastasis from disseminated cervical squamous cell carcinoma. A 52-year-old woman presented with progressive bilateral visual loss due to choroidal masses in both eyes. The fundus examination revealed posterior serous retinal detachment in both eyes associated with creamy choroidal lesions. A thorough systemic work-up revealed choroidal metastasis from a squamous cell carcinoma of the cervix. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss

Shibeeb

Athanasiov

Simon

et al. 2014

Case Reports in Ophthalmological Medicine

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“…In the context of external-beam radiotherapy, serous RD has been observed as a complication either of metastasis or of the therapy itself of intraocular malignancies [2,9,10], but has never been reported for extraocular malignancies without any ocular involvement. However, in our case, clinical examination and ultrasonography excluded the presence of a chorioretinal tumor.…”

Section: Discussionmentioning

confidence: 99%

Bilateral rhegmatogenous retinal detachment after external-beam radiotherapy: just a coincidence?

Kodjikian

Garweg

Fleury

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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Conclusion Sedentary work defined by a wide-range group of occupations, is not a risk factor for VTE. Whether certain occupations with particularly high exposure to immobilised sitting positions are associated with thromboembolic events is not addressed. Objectives As the evidence on the possible association between lifting and retinal detachment (RD) is limited and controversial , we analysed a large population-based cohort to investigate the risk of RD arising from occupational lifting. Methods We assessed the incidence of surgically treated RD occurring between 1991 and 2009 in a national cohort of 49,321 Swedish men conscripted for military service in 1969-1970. We applied a job exposure matrix to occupational data from the 1990 census to estimate the frequency of heavy lifting (>20-25 kg) at the workplace. We fitted Poisson regression models including lifting, myopia, income, and education level to estimate incidence rate ratios (IRR) and 95% confidence intervals of RRD. Results We analysed 217 RD cases that occurred in 7 80 166 person-years. Estimates adjusted by myopia and socioeconomic factors support the hypothesis that the risk of RD increases among subjects lifting heavy weights at least twice per week, compared to workers not performing lifting (IRR 2.38, 95% CI 1.15-4.93, p for trend across lifting categories 0.014). Myopia was a strong negative confounder of the lifting -RD association. While RD was rare in the entire cohort (0.28 cases per 1000 person-years), the rate peaked at 7.9 per 1000 person-years among workers frequently lifting heavy loads, aged between 50 and 59 years, and affected by severe myopia. Conclusions Our study provides evidence that performing heavy occupational lifting increases the risk of RD, while myopia and socioeconomic factors may be important negative confounders of this association. Objective To investigate the association between external beam radiotherapy (EBRT) for prostate adenocarcinoma (PA) and malignant peritoneal mesothelioma (MPM) using data from the US Surveillance, Epidemiology and End Results (SEER) program. Methods We identified PA cases diagnosed in 1973-2013 among patients aged !45 years. The follow-up started one year after the primary diagnosis (to exclude synchronous cancers and limit surveillance bias) and ended at the diagnosis of MPM, other malignancies, death, or at the study end (12/31/ 2013). We estimated hazard ratios (HR) and 95% confidence intervals (95% CI) of MPM for EBRT, compared to no radio-therapy, by fitting Cox models incorporating inverse probability weights to account for age at diagnosis, race, year of diagnosis, primary cancer surgery, SEER register, and county's mesothelioma relative risk (proxy for individual asbestos exposure). Results We observed 34 MPM cases occurring in 4,755,045 person-years (rate of 0.7 per 1 00 000 person-years, 95% CI 0.5-1.0). The risk of MPM was higher among EBRT patients (HR 2.1, 95% CI 0.9-4.8) and increased steadily with increasing latency period (1-4 years, HR 1.3, 95% CI 0.4-4.6; 5-9 years, HR 1.9...

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“…Human papillomavirus is a well established cause of oropharyngeal squamous carcinoma, increasing in incidence recently [4]. Rare cases of squamous cell carcinoma with non-oropharyngeal, non-pulmonay primary sites such as esophagous, uterus and thyroid have been published [5][6][7][8]. Our case presented as a large amelanotic mushroom shaped tumor with intrinsic vasculature.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Metastatic to the Choroid

Mendez¹,

Biscotti²,

Singh³

2014

J Cytol Histol

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We describe a 64-year-old caucasian man with squamous cell carcinoma of the base of the tongue that metastasized to the choroid. The primary tumor was known to be high risk HPV positive and initially diagnosed as T3N3M0 stage IVB two years prior to presentation. Funduscopy revealed an 18 x 17 x 8.9 millimeter mushroom shaped amelanotic tumor with intrinsic vascularity. Ultrasonography revealed medium to high internal reflectivity with echolucent pockets and a positive angle kappa. Marked intrinsic vascularity and associated retinal detachment was also observed. Fine needle aspiration biopsy was performed and 40cGy where delivered via plaque brachytherapy. Histopathologic and cytologic findings of the primary tumor and of the choroidal tumor, respectively are discussed in detail.Keywords: Metastasis; Choroid; Cytology; Fine needle aspiration Case PresentationA 64-year-old caucasion man with a ten-day history of a superior scotoma on the right eye was initially seen by his optometrist who referred him to ophthalmic oncology clinic at Cole Eye Institute for evaluation of a mushroom shaped choroidal tumor (right eye). The patient had no other ophthalmic complaints. His past medical history was significant for recurrent high risk type humanpapillomavirus squamous cell carcinoma (SCC) of the oropharynx (base of the tongue) ( Figure 1A and B). Two years prior to presentation the patient had noted a neck mass that on workup was found to be SCC with extensive cervical lymphadenopathy and absent distant metastatic disease (T3N3M0). At that time he was treated with surgery and 7350cGy in 35 fractions with concurrent cisplatin. Left facial nerve palsy with exposure keratopathy required upper eyelid gold weight placement. His last chemotherapy dose was seven months prior to presentation of visual symptoms. Metastatic disease to the lung and left ear was noted at this time and because of this he was scheduled to re-start chemotherapy. Family history and social history where not contributory. He had no known allergies and was on a multivitamin and levothyroxine 100 micrograms once a day.Ophthalmic examination revealed best corrected visual acuity of 20/125 OD and 20/25 OS with pressures of 10 and 11 mmHg respectively. No afferent pupillary defect was observed. Visual fields by confrontation confirmed a scotoma of the superior visual field of the right eye. External examination revealed left sided partial facial paresis with minimal lagophthalmos. On anterior segment slit lamp examination of the right eye, inferior feeder vessels were noted ( Figure 2A). Fundus examination of the right eye revealed a mushroom shaped amelanotic cilio-choroidal mass measuring approximately 18 x 17 x 9 mm in size. An overlying serous retinal detachment from 3 to 9 o´clock was present. Intrinsic vascularity was observed within the tumor ( Figure 2B). Ultrasonography revealed a lobulated lesion at 6:00 o ´clock posterior to the equator. The tumor was irregularly structured with medium to high internal reflectivity anteriorly and low reflect...

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Bilateral choroidal metastases secondary to uterocervical carcinoma of the squamous cell type

Cited by 14 publications

References 3 publications

Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss

Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss

Bilateral rhegmatogenous retinal detachment after external-beam radiotherapy: just a coincidence?

Squamous Cell Carcinoma Metastatic to the Choroid

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