Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss

Abstract

We report a patient with bilateral choroidal metastasis from disseminated cervical squamous cell carcinoma. A 52-year-old woman presented with progressive bilateral visual loss due to choroidal masses in both eyes. The fundus examination revealed posterior serous retinal detachment in both eyes associated with creamy choroidal lesions. A thorough systemic work-up revealed choroidal metastasis from a squamous cell carcinoma of the cervix. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours.

Intraocular metastasis from primary cervical cancer: A case report and review of the literature

“…The size of the nodule was reduced with radiotherapy ( Kurosawa and Sawaguchi, 1987 ). Three of the patients described in the case reports died only 3 months after diagnosis ( Shibeeb et al, 2014 , Inoue et al, 2000 , Kurosawa and Sawaguchi, 1987 ), highlighting the advanced extent of disease leading to hematogenous spread. Our patient died 5 months after her initial eye complaints.…”

“…The keywords “uveal or choroidal” AND “cervix or cervical” AND “cancer or metastasis” produced 106 results which were screened by title and abstract, with 4 relevant case reports found ( Table 1 ). Three cases of cervical carcinoma with metastases to the choroid, two cases of squamous cell carcinoma (SCC) ( Shibeeb et al, 2014 , Inoue et al, 2000 ) and one of adenocarcinoma ( Wiegel et al, 1995 ), as well as 1 case of SCC with metastasis to the iris ( Kurosawa and Sawaguchi, 1987 ) were found. The median of 5 cases including our experienced case with eye metastasis of cervical cancer was 53 (range, 25–55).…”

“…In a report by Shibeeb et al, they described the case of a 52-year-old woman with progressive and painless bilateral vision loss due to retinal detachment in both the right and left eyes ( Shibeeb et al, 2014 ). The patient was subsequently diagnosed with metastatic SCC of the cervix.…”

“…Our patient died 5 months after her initial eye complaints. Intraocular metastasis among all patients holds a life expectancy of about 9 to 10 months ( Shibeeb et al, 2014 ). One can assume that the diagnosis of metastasis to the eye from a primary cervical tumor is a poor prognostic indicator.…”

Cervical carcinoma metastasizing to uveal tissue manifesting as pseudohypopyon

“…On review of the literature, five cases of carcinoma cervix with uveal tissue metastasis have been reported. Four cases had metastasis to choroid, two were adenocarcinoma, [6,7] two cases were of squamous cell carcinoma, [8,9] and one case was squamous cell carcinoma with metastasis to the iris. [10] The treatment is prescribed to the patients with symptomatic disease and a tumor that threatens visual acuity.…”