Bilateral acute iris transillumination following systemic administration of antibiotics

Tranos, Paris; Lokovitis, Evangelos; Masselos, Stelios; Kozeis, Nikolaos; Triantafylla, Magda; Markomichelakis, Nikolaos

doi:10.1038/s41433-018-0054-y

Cited by 24 publications

(18 citation statements)

References 23 publications

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“…Of these 93 cases, 14 were part of a review of the literature11 and therefore were omitted leaving only 79 clinical cases listed in isolation. There are mainly three large studies: by Tugal-Tutkun et al3 in Turkey and Belgium in 2011 (26 cases), by Kreps et al12 in Belgium in 2017 (12 cases), and by Tranos et al13 in Greece in 2018 (16 cases). The other articles report mainly isolated cases of BAIT syndrome.…”

Section: Methodsmentioning

confidence: 99%

“…Nevertheless, according to World Health Organization criteria, the relationship between fluoroquinolone therapy and uveitis is considered “possible”, as observed in a retrospective analysis of 40 cases of uveitis found in the literature. 11 In the majority of cases, systemic administration of moxifloxacin is reported prior to the onset of BAIT syndrome 2,11–13,18,19. And Kawali et al reported 2 cases of BAIT with a history of topical use of fluoroquinolones.…”

Section: Methodsmentioning

confidence: 99%

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<p>Bilateral acute iris transillumination (BAIT) syndrome: literature review</p>

Perone

Chaussard

Hayek

2019

OPTH

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The authors conducted a literature review about bilateral acute iris transillumination (BAIT) syndrome, a new and relatively unknown syndrome that should be described and made known to the greatest number to avoid potential diagnostic and therapeutic errors. The first cases date back only to 2004 and a total of 79 cases have been published to date, mainly in Europe and especially in Turkey and Belgium. It mainly affects young women between the ages of 30 and 50, and symptoms are often preceded by an upper airway infection. There is also a majority of cases where the onset of the syndrome follows oral intake of moxyfloxacin. The clinical signs are dominated by strong photophobia, secondary to a spectacular transillumination of the iris. Other classical symptoms are conjunctival infection, eye pain, blurred vision, temporary ocular hypertonia, fixed mid-dilated pupils, and pigment dispersion in the anterior chamber with pigmentary deposits in the trabecular meshwork in gonioscopy, symptoms that may be mistaken for uveitis. After a few weeks or months of evolution, persistent sequelae were pupillary atony and chronic and bilateral transillumination of the iris, leading to significant photophobia and sometimes persistent ocular hypertension. The BAIT syndrome is close to the bilateral acute depigmentation of the iris (BADI) syndrome, which is similar to BAIT but lacks associated transillumination. A few cases of patients with BAIT syndrome on one eye and BADI syndrome on the contralateral eye have been described, which confirms some form of link between the two clinical entities.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

<p>Bilateral acute iris transillumination (BAIT) syndrome: literature review</p>

Perone

Chaussard

Hayek

2019

OPTH

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“…Most of the studies noted a correlation with the oral administration of antibiotics such as moxifloxacin and clarithromycin. Tranos P et al [2] published a series of 16 cases with previous administration of systemic moxifloxacin (13 patients) or clarithromycin (3 patients), the antibiotic given to our patient. Eleven out of 16 patients were first time users of moxifloxacin or clarithromycin.…”

Section: What Is the Role Of Antibiotic Administration In Bait?mentioning

confidence: 87%

Two Rare Causes of Anterior Pseudo-Uveitis Affecting the Iris: Sequelae of Bilateral Acute Iris Transillumination (BAIT) Syndrome and Iridocorneal Endothelial (ICE) Syndrome

Papasavvas¹,

Lehoang

Herbort³

2021

Klin Monbl Augenheilkd

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Axenfeld-Rieger syndrome BADI bilateral acute depigmentation of the iris BAIT bilateral acute iris transillumination ICE iridocorneal endothelial IOP intraocular pressure OD oculus dexter, right eye OS oculus sinister, left eye OU oculus uterque, both eyes PVRL primary vitreoretinal lymphoma RNFL retinal nerve-fibre layer SD-OCT spectral domain optical coherence tomography UBM ultrasound biomicroscopy

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“…12 This entity predominantly affects females around 40 years of age. 12,13 Patients with BAIT present with similar but more severe symptoms compared to BADI patients. Both eyes are involved simultaneously with severe photophobia and red eyes, but symptom severity can be asymmetrical.…”

Section: Introductionmentioning

confidence: 98%

“…Pigment showering is severe during the first few weeks following symptom onset and declines over time. 13 As the pigment dispersion starts to clear, diffuse iris transillumination and irregularly mydriatic pupils that are poorly responsive or unresponsive to light become apparent and higher IOP levels are measured. Iris transillumination and mydriasis may increase with continued pigment circulation, pigment dusting on the corneal endothelium and on the surface of the lens is seen, posterior synechiae may develop, and IOP rise may become uncontrollable with antiglaucoma medications.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Acute Depigmentation of Iris (BADI) and Bilateral Acute Iris Transillumination (BAIT)-An Update

Tuğal-Tutkun¹,

Altan²

2022

tjo

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Clinical Features of BADI BADI was first described in 2006 by Tugal-Tutkun and Urgancioglu 1 in a series of 5 cases from Turkey. They described an acute episode of pigment discharge in the anterior chamber from the iris stroma, bilateral symmetrical diffuse or geographical areas of depigmentation and discoloration of the iris stroma, Krukenberg's spindles, and pigment deposition in the trabecular meshwork. In their subsequent series, Tugal-Tutkun et al. 3 described 26 new cases and long-term follow-up of 2 cases. Following these early publications, many cases have been reported from other countries. 4,5,6,7,8,9 BADI affects predominantly young females. It presents as a sudden-onset redness, ocular pain, tearing, and photophobia in both eyes simultaneously or within a few days of each other. Severe photophobia is the most prominent symptom. The patients usually maintain normal visual acuity. 1,3,4,5 Patients with BADI present with severe diffuse episcleral injection, more pronounced than ciliary injection. They do not have signs of intraocular inflammation, but they present with circulating pigment in the anterior chamber, which may

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Bilateral acute iris transillumination following systemic administration of antibiotics

Abstract: BAIT represents a rare clinical entity with characteristic features. Although etiopathogenesis of this condition remains unclear, a series of cases that indicate a strong correlation between systemic antibiotic administration and BAIT is herein presented.

Cited by 24 publications

References 23 publications

<p>Bilateral acute iris transillumination (BAIT) syndrome: literature review</p>

<p>Bilateral acute iris transillumination (BAIT) syndrome: literature review</p>

Two Rare Causes of Anterior Pseudo-Uveitis Affecting the Iris: Sequelae of Bilateral Acute Iris Transillumination (BAIT) Syndrome and Iridocorneal Endothelial (ICE) Syndrome

Bilateral Acute Depigmentation of Iris (BADI) and Bilateral Acute Iris Transillumination (BAIT)-An Update

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