Bilateral Acoustic Neuroma: A Human Temporal Bone Report

Benitez, Jaime T.; Lopez-Rios, Guillermo; Novoa, Victor

doi:10.1001/archotol.1967.00760050027006

Cited by 16 publications

(12 citation statements)

References 4 publications

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“…16 Given that all vestibular organs appeared morphologically normal in our series, it is not surprising that previous LM descriptions of the vestibular labyrinth in VS ears report normal-appearing maculae and cristae. 6,9,10 While 1 LM report notes that the posterior crista appeared to be missing about 30% of its hair cells, no counts were performed. 9 In contrast, differential interference contrast microscopy permitted us to focus up and down through each slide at high magnification to create optical sections with high degrees of contrast that allowed for the differentiation of cell types.…”

Section: Discussionmentioning

confidence: 99%

“…Prior histopathologic descriptions of VS of all sizes note ipsilateral inner ear changes, including endolymphatic hydrops and acidophilic-staining precipitate within the endolymph and perilymphatic compartments. 6,[9][10][11][12][13] This precipitate is considered to be the histopathologic correlate of the higher inner ear protein content present in ears with VS and may represent biochemical degradation of the inner ear fluids. 7,14,15 Cochleae ipsilateral to VS have also been found to have greater losses of inner and outer hair cells and cochlear neurons when compared with unaffected ears.…”

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confidence: 99%

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Quantitative Vestibular Labyrinthine Otopathology in Temporal Bones with Vestibular Schwannoma

Hızlı

Cüreoğlu²,

Kaya

et al. 2015

Otolaryngol.--head neck surg.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Quantitative Vestibular Labyrinthine Otopathology in Temporal Bones with Vestibular Schwannoma

Hızlı

Cüreoğlu²,

Kaya

et al. 2015

Otolaryngol.--head neck surg.

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“…Another factor that provided impetus for the present report is that the literature contains limited data describing temporal bone histopathology in NF2. Previous descriptions have consisted of one to three cases each3–7 or reports focused on patterns of involvement of the cochlear nerve 8, 9…”

Section: Introductionmentioning

confidence: 99%

Temporal bone histopathology in neurofibromatosis type 2

2011

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Objective To describe the histopathological findings in the temporal bone in patients with NF2. Background The literature contains limited data on otopathology of NF2. Methods 26 temporal bones from 16 patients with NF2 were examined by light microscopy. The diagnosis of NF2 was made on the basis of bilateral cochleovestibular schwannomas. Clinical information was obtained from review of the medical records. Results The tumors were multicentric in origin in 19/26 (73%) ears. Typically, tumors were seen arising within the internal auditory canal and from various locations within the labyrinth. The majority of schwannomas showed high cellularity with involvement of the labyrinth. Most cases showed significant degrees of degeneration of sensory and neural elements within the cochlea. Fusion tumors were sometimes seen as a result of a schwannoma merging with an adjacent meningioma. 15/26 (58%) ears showed facial nerve involvement by schwannoma. Conclusions Cochleovestibular schwannomas in NF2 are aggressive neoplasms; they are often multicentric, and demonstrate a propensity to involve the labyrinth. There is often associated secondary degeneration within the cochlea. These features make total removal of these tumors and their removal with preservation of hearing more difficult than with sporadic unilateral cochleovestibular schwannoma. Level of Evidence N/A

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“…Animal studies have shown that vascular occlusion affected cochlear sensory cells, with a tendency of more basal turn degeneration along the cochlear length [32]. Moreover, some histopathologic studies of temporal bones with vestibular schwannomas showed that the hair cells of the organ of Corti were well preserved in the middle and apical turns [33][34][35]. Accordingly, high frequency hearing loss in vestibular schwannomas may be induced by compromising blood flow in the labyrinthine artery, which mediated the atrophy of the sense organ toward the basal turn.…”

Section: Discussionmentioning

confidence: 99%

Cochlear Microphonic Potentials in Patients with Vestibular Schwannomas

Noguchi

Komatsuzaki²,

Nishida³

1998

ORL

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We evaluated the cochlear function of 44 patients with unilateral vestibular schwannomas by measuring cochlear microphonic potentials (CM) in electrocochleography. We used short tone bursts with 0.5-, 1-, 2-, and 4-kHz frequencies as acoustic stimuli to evoke CMs, and determined CM detection thresholds. The CM detection thresholds in vestibular schwannomas ranged from normal to no response. Cochlear dysfunction was seen in 35 (79.5%) of the 44 cases; these patients had higher CM detection thresholds than normal subjects. Although a significant correlation was found between mean hearing level (0.5–4 kHz) and mean CM detection threshold (0.5–4 kHz), 20 patients had lower CM detection thresholds than were found using audiometry. This suggests that there is an additional retrocochlear component responsible for this hearing loss.

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Bilateral Acoustic Neuroma: A Human Temporal Bone Report

Cited by 16 publications

References 4 publications

Quantitative Vestibular Labyrinthine Otopathology in Temporal Bones with Vestibular Schwannoma

Quantitative Vestibular Labyrinthine Otopathology in Temporal Bones with Vestibular Schwannoma

Temporal bone histopathology in neurofibromatosis type 2

Cochlear Microphonic Potentials in Patients with Vestibular Schwannomas

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