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Peripheral vestibular otopathology, manifested as reductions of vestibular hair cell densities, was identified in ears with vestibular schwannoma. Labyrinthine as well as retrolabyrinthine pathology may contribute to tumor-related vestibular dysfunction.

These findings suggest that such patients could be good candidates for hearing aid or cochlear implant if they have profound sensorineural hearing loss.

Purpose-To determine histopathologic findings in the cochlea of human temporal bones with serous labyrinthitis.Materials and Methods-We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis Results-The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P = 0.006), upper basal (P = 0.005), and lower middle (P = 0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P = 0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and FIBROCYTES IN THE SPIRAL LIGAMENT, and in areas of the stria vascularis and spiral ligament (P > 0.05).Conclusions-Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.

Type I hair cells in peripheral vestibular organs are affected in patients with SLE. Our findings could provide a pathologic basis for the difficulty with balance experienced by patients with SLE.

Objectives To determine if peripheral vestibular otopathology is present in human temporal bones with otosclerosis. Study Design Comparative human temporal bone study Methods Seventy-four human temporal bones from 46 subjects with otosclerosis (mean age of 61±18 years) and 20 within histologically normal limits from 17 subjects (mean age of 59±14 years) were included in this study. Temporal bones with otosclerosis were divided into those with and without endosteal involvement. Using differential interference contrast microscopy at 1008x magnification, type I and type II vestibular hair cell counts were performed on each vestibular sense organ in which the neuroepithelia was oriented perpendicular to the plane of section. The organ-specific cell densities (cells/0.01 mm2 surface area) were compared between the groups with and without endosteal involvement and also compared to counts in the non- otosclerosis control group using Student’s t-test. Results Mean type I and type II hair cell densities of all vestibular structures in the group with endosteal involvement were significantly lower compared to the group without endosteal involvement. Mean type I and type II hair cell densities of all vestibular structures in the group with endosteal involvement were also significantly lower compared to the control group but were not in the group without endosteal involvement compared to the control group. Conclusion Endosteal involvement of otosclerotic foci is associated with damage to the vestibular sensory neuroepithelia that may contribute to the vestibular symptoms in otosclerosis.

Aim. OSAS is a disease characterized by repetitive air flow constraint or cessation due to airway collapse. Diseases that frequently coexist with OSAS and simple snoring were evaluated in this study. Materials and Methods. This study was conducted in the Otorhinolaryngology Department of the Ankara Numune Hospital between April 2008 and April 2010 with 130 patients who presented with the complaints of snoring, witnessed apnea, and daytime drowsiness. Presence of chronic disease was compared to the demographics, BMIs, Epworth Scale scores, polysomnography, and physical examination findings. Results. Comorbid diseases were present in 56 (43.1%) of the patients, and the most presented disease group was cardiovascular system diseases. Age, BMI, daytime drowsiness, and frequency of septum deviation were observed at higher rates in patients with chronic disease. Age, BMI, and frequency of septum deviation were associated with cardiovascular diseases. Endocrine disease was found to increase with decreased oxygen saturation. Neuropsychiatric diseases were associated with daytime drowsiness and age. The mean age was lower in cases with cigarette smoking compared to cases without. Conclusion. Frequency of the comorbidities mostly increased with age as expected. Comorbid diseases were also associated with obesity and daytime drowsiness. Cigarette smoking was associated with early-age disease.