Biji Mahoni (Swietenia Mahagoni) Menurunkan Glukosa Darah Pada Diabetes Melitus Tipe Ii

Abstract

AbstrakKontrol glukosa darah dapat dilakukan dengan terapi farmakologi dan tanaman berkhasiat obat atau herbal. Obat herbal yang mempunyai efek hipoglikemik salah satunya adalah biji mahoni yang berfungsi sebagai astrigen menghambat asupan glukosa dan laju peningkatan glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh biji mahoni terhadap kadar glukosa darah pada penderita diabetes melitus tipe II, dengan desain penelitian adalah quasi eksperimental ''Pre and Post-Test Control Group Design'', pada desain ini responden penelitian dibagi menjadi dua kelompok. 34 responden kelompok intervensi, dan 34 responden kelompok kontrol sebagai pembanding. Pengumpulan data dilakukan dengan pemeriksaan kadar glukosa darah pre dan post perlakuan, lembar observasi dan hasil penelitian dianalisis secara univariat dan bivariat dengan menggunakan uji Wilcoxon.Hasil penelitian menunjukkan sebanyak (100%) responden sebelum dilakukan intervensi dan pemberian glibenklamide dengan kadar glukosa darah > 200 mg/dl. Sebanyak (85,3%) responden sesudah intervensi dengan nilai kadar glukosa darah 90-199 mg/dl. Dari analisis bivariat terdapat pengaruh biji mahoni terhadap kadar glukosa darah dengan nilai pvalue = 0,000 (p<0,05). Biji mahoni lebih berpotensi menurunkan kadar glukosa darah dibandingkan dengan glimepiride dengan beda rerata median 17,5 mg/dl. '', in Kata Kunci: Biji Mahoni, Glukosa Darah, Diabetes Melitus Tipe II Abstract Glycemic control can be performed by pharmacological therapy and herbs medicine. One of herbs medicine have a hypoglycemic effect which is mahogany seeds that serves as astrigentinhibiting glucose intake and the rate of increase in blood glucose. This study aims to determine the effect of mahogany seeds on blood glucose levels in people with type II diabetes mellitus, Designof this research is quasi-experimental '' Pre and Post Test Control Group Design

Effectiveness of Dry Extract Mahoni Seed Consumption on Blood Sugar Level in Diabetes Mellitus Patients

“…Saponin content serves to treat diabetes mellitus due to hypoglycemic effects of saponins stronger than generic antidiabetes drugs, while the content of alkaloids are effective to detoxify and prevent oxidants in tubuk because the body becomes alkaline (Sahgal et al, 2009) . The results of this study support research conducted by Ani Astutik (2017) which states that mahogany seeds are one of the herbal plants that can lower blood glucose in patients with diabetes mellitus because it has a better taste for the enzyme ⍺-glucosidase and also has the ability as an astrigen, can precipitate proteins and form a protective layer of intestines, thus inhibiting glucose intake and blood glucose increase rate is not very high (Astuti, 2018). The results of this study were also supported by research conducted by Suryani et al (2013) on the effect of administering methanol extract of Mahogany seeds in mice, obtained increased insulin levels and repair of pancreatic tissue in mice (Suryani, Endang H, & Aulanni'am, 2013).…”

“…Problems that often arise in people with Diabetes Mellitus is how to maintain blood glucose levels to stay controlled and avoid complications such as cardiovascular disease, blindness, amputation, disability and reduce the life expectancy of patients (Astuti, 2018;Kemenkes RI, 2013). One of the pillars of diabetes mellitus management is the use of synthetic anti-diabetic drugs, although the administration of drugs often cause side effects.…”

Characterization and Screening Active Phytochemical Compounds of 70% Ethanol Extract of Mahogany Seed (Swietenia mahagoni Jacq.)

“…Besides, mahogany seeds can increase body weight, the content of the enzyme superoxide dismutase in pancreatic tissue, and reduce the rate of damage from beta-pancreatic cells (Wresdiyati et al, 2015). Tests on humans show that mahogany seeds have a more significant effect on reducing blood glucose levels compared to the antidiabetic drug Glimepiride (Astuti et al, 2017). Research on the search for herbal remedies mostly provides information that the hypoglycemic effect produced by mahogany plants originates from the mechanism of action of active compounds from secondary metabolites such as flavonoid, phenolic, terpenoid, steroid, glycoside, saponin, alkaloid, tannin, or anthraquinone classes contained therein (Ahmad et al, 2019;Moghadamtousi et al, 2013;Oboh et al, 2017).…”