The commercial used the 555 single timer and the 741 operational amplifiers (op-amp) were investigated under the gamma-ray radiation of the Co-60 source. The maximum total doses were used 2 kGy and 4 kGy to irradiate. The abnormal behavior in the 555 single timer circuit frequency was observed, which decreased from 202 to 195 Hz at 744 Gy gamma-ray radiations. In the 741 op-amp circuit, the output signal dropped from 1.28 to 1.25 under the same radiation dose. The loss of output amplitude was calculated at about 2.3 % when the radiation dose was 4 kGy. At the same time, the gain of the 741 op-amp decreased from 9.88 to 9.84 and its slew rate drops from 4 to 0.65 V/µs. The 555 single timer has two pn junctions and these diodes cause the 555 single timer to be easily affected by gamma radiation. Consequently, the integrated circuits must be tested to determine their resistance limits in the radiation environments.