Big Data Reveal Insights into Alopecia Areata Comorbidities

Lim, Chean Ping; Severin, Rachel K.; Petukhova, Lynn

doi:10.1016/j.jisp.2017.10.006

Cited by 17 publications

(19 citation statements)

References 24 publications

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“…found that the LDL levels of women with AA were higher than those of healthy women. [7] The authors clearly suggested a link among lipid metabolism, cholesterol biosynthesis, and hair disorders in this report. In contrast, the present study revealed that the lipid profiles of the AA patients and healthy controls were comparable.…”

Section: Discussionmentioning

confidence: 58%

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Assessment of metabolic profile and ischemia-modified albumin level in patients with alopecia areata: A case–control study

et al. 2019

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Background:Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there is no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which is proposed as an oxidative stress biomarker in patients with AA.Aims:The aim was to investigate the presence of metabolic syndrome and the levels of IMA, small dense low-density lipoprotein (sd-LDL), and visfatin levels in AA patients.Settings and Design:A hospital-based cross-sectional study was undertaken among AA patients and controls.Subjects and Methods:Thirty-five patients with AA and 35 sex-, age-, and body mass index-matched healthy controls were enrolled. Clinical and laboratory parameters of metabolic syndrome were examined in all participants. Furthermore, IMA, sd-LDL, and visfatin levels were assessed and analyzed with regard to disease pattern, severity and extent, severity of alopecia tool score, duration, and recurrence.Results:The median IMA and adjusted IMA levels were significantly increased compared with controls (P<0.05 and P=0.002, respectively). Patients with pull test positivity displayed higher levels of adjusted IMA levels (P<0.05). In AA group, there was a positive correlation between adjusted IMA and waist circumference (r=0.443, P=0.008), adjusted IMA and triglyceride levels (r=0.535, P=0.001), and adjusted IMA and sd-LDL levels (r=0.46, P<0.05). We observed no statistically significant difference in fasting blood glucose and lipid profile, sd-LDL, and visfatin levels of the patients and healthy controls.Conclusions:AA patients and controls have similar metabolic profile. Raised levels of adjusted IMA levels may be associated with antioxidant/oxidant imbalance and with risk of cardiovascular disease.

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Section: Discussionmentioning

confidence: 58%

“…suggested possible metabolic comorbidities, including hyperlipidemia in AA. [7] Increased level of small dense low-density lipoprotein cholesterol (sd-LDL-C) is one of the main components of atherogenic dyslipidemia. [8]…”

Section: Introductionmentioning

confidence: 99%

Assessment of metabolic profile and ischemia-modified albumin level in patients with alopecia areata: A case–control study

et al. 2019

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“…The most common is thyroid disease, which is found in 19% of patients;[ 30 31 ] however, AA is also reported to be associated with diabetes mellitus, psoriasis, vitiligo, lupus, multiple sclerosis, and rheumatoid arthritis. [ 32 ] In addition, patients with AA have an increased risk for atopic diseases, such as atopic dermatitis, allergic rhinitis, and asthma. [ 33 34 ] Interestingly, nutritional deficiencies, including Vitamin D and iron are also more common in AA patients[ 33 35 ] as are sleep disorders.…”

Section: Physical Co-morbiditiesmentioning

confidence: 99%

Cumulative life course impairment of alopecia areata

et al. 2020

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Alopecia areata (AA), an unpredictable, nonscarring hair loss, is commonly perceived as a cosmetic, rather than medical, concern. However, substantial evidence exists describing the negative impact on quality of life, as the disease affects patients personally, socially, financially, and physically. Over time, the cumulative disability may perpetuate poor confidence, social disconnection, negative coping strategies, and failure to achieve a full life potential. Here, we describe the cumulative life course impairment (CLCI) of AA by examining the complex interaction of (1) stigmatization, (2) physical and psychiatric comorbidities, and (3) coping strategies. The model aggregates existing cross-sectional data, which have previously captured disease burden only as snapshots in time. Thus, by examining cumulative effects, the CLCI model serves as a proxy for longitudinal data to better describe life course epidemiology of the disease.

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“…Очаговая алопеция (ОА) является распространенным воспалительным иммуноопосредованным заболеванием, при котором запускается аутоиммунный ответ, направленный на волосяные фолликулы, что приводит к нерубцовому выпадению волос на коже головы, лице и других участках кожного покрова. Частота встречаемости очаговой алопеции в мире составляет около 2% среди всех кожных заболеваний [11,12].…”

Section: Introductionunclassified

“…Определе- но, что HLA-AI, HLA-DQ1 и HLA-DQ3 встречались значительно чаще у больных ОА в сравнении с контрольной группой [5]. Повышенная концентрация адренокортикотропного гормона, кортикостерона и эстрадиола коррелировали с повышенным уровнем провоспалительных цитокинов в коже, что указывает на потенциальную роль психологических и патофизиологических факторов, вызывающих ОА [11]. Кроме того, триггерами ОА могут быть травма, инфекции, вакцинация, изменение характера питания, дисбаланс концентрации витаминов А и D [9].…”

Section: Introductionunclassified

Сlinical case of focal alopecia in a child with atopy

Барило¹,

Смирнова²,

Олянина³

2021

Med. immunol.

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Alopecia areata is a common inflammatory immune-mediated disorder in which autoimmune response is triggered against hair follicles, thus leading to non-scarring hair loss on the scalp, face and other parts of the skin. Despite numerous studies concerning this issue, today there is no consensus on the etiology and pathogenesis of focal alopecia. In the literature, special attention is paid to association of focal alopecia with autoimmune diseases, such as rheumatoid arthritis, celiac disease, type 1 diabetes, psoriasis, autoimmune thyroiditis, vitiligo. Recent studies have identified the association of focal alopecia with atopic diseases (allergic rhinitis, bronchial asthma, atopic dermatitis) and the early debut of severe forms of hair loss. The aim of this study was to present a clinical case of focal alopecia in an 8-year-old girl with atopic bronchial asthma and seasonal allergic rhinitis. As based on detection of eosinophilia in peripheral blood and a high concentration of total IgE in serum, one may assume that atopic alopecia is the cause of focal hair losses in a child with atopy. The patient underwent skin prick testing, in order to determine sensitization for food components, pollen and fungal allergens. As a result of skin testing, a hyperergic reaction (> 15 mm in diameter) to tree pollen was revealed, a positive response (6-9 mm) to oatmeal, a weakly positive reaction (3-5 mm) to whole chicken egg, carrots, tomato, apple, pear, pollen of meadow, cereal, weed grasses was also revealed. With regard of these allergological data, an individual diet was recommended with the elimination of causally significant allergens (including those eliciting weakly positive reactions), external treatment, i.e., topical calcineurin inhibitors administered for 1 month. One month later, an improvement of the pathological process was registered, and 6 months from the start of therapy, complete restoration of hair follicles was noted in the focus of alopecia. The patient was monitored for a year, no complaints of hair loss were noted. The positive effect of elimination against the background of the appropriate elimination diet with respect to causally significant allergens, was also noted when treating her for respiratory allergy, i.e., the patient did not have seasonal manifestations of hay fever over the next pollination period. This clinical case is demonstrated in order to draw special attention of dermatologists, allergologists, immunologists, general practitioners to the issues of focal alopecia in children against the background of typical allergic diseases.

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Big Data Reveal Insights into Alopecia Areata Comorbidities

Cited by 17 publications

References 24 publications

Assessment of metabolic profile and ischemia-modified albumin level in patients with alopecia areata: A case–control study

Assessment of metabolic profile and ischemia-modified albumin level in patients with alopecia areata: A case–control study

Cumulative life course impairment of alopecia areata

Сlinical case of focal alopecia in a child with atopy

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