Bifunctional Au@Bi₂Se₃ Core–Shell Nanoparticle for Synergetic Therapy by SERS‐Traceable AntagomiR Delivery and Photothermal Treatment

Abstract

For the first time, topological insulator bismuth selenide nanoparticles (Bi Se NP) are core-shelled with gold (Au@Bi Se ) i) to represent considerably small-sized (11 nm) plasmonic nanoparticles, enabling accurate bioimaging in the near-infrared region; ii) to substantially improve Bi Se biocompatibility, iii) water dispersibility, and iv) surface functionalization capability through straightforward gold-thiol interaction. The Au@Bi Se is subsequently functionalized for v) effective targeting of SH-SY5Y cancer cells, vi) disrupting the endosome/lysosome membrane, vii) traceable delivery of antagomiR-152 and further synergetic oncomiR knockdown and photothermal therapy (PTT). Unprecedentedly, it is observed that the Au shell thickness has a significant impact on evoking the exotic plasmonic features of Bi Se . The Au@Bi Se possesses a high photothermal conversion efficiency (35.5%) and a remarkable surface plasmonic effect (both properties are approximately twofold higher than those of 50 nm Au nanoparticles). In contrast to the siRNA/miRNA delivery methods, the antagomiR delivery is based on strand displacement, in which the antagomiR-152 is displaced by oncomiR-152 followed by a surface-enhanced Raman spectroscopy signal drop. This enables both cancer cell diagnosis and in vitro real-time monitoring of the antagomiR release. This selective PTT nanoparticle can also efficiently target solid tumors and undergo in vivo PTT, indicating its potential clinical applications.

Fabrication of Troponin I Biosensor Composed of Multi-Functional DNA Structure/Au Nanocrystal Using Electrochemical and Localized Surface Plasmon Resonance Dual-Detection Method

“…Based on these results, the proposed EC-LSPR dual detection biosensor composed of multi-functional DNA and AuNC exhibits simplicity, label-free detection, high sensitivity, and selectivity for the clinical assessment of AMI disease. Moreover, the proposed dual detection system can be tuned to sensitivity by introducing the plasmonic nanomaterials such as MoO 3 , MoS 2 and Bi 2 Se 3 , not only AuNC [32,33,34]. Additionally, the cross testing can reduce the detection error and increase the detection accuracy for portable AMI diagnosis system construction.…”

NIR Light‐Driven Bi2Se3‐Based Nanoreactor with “Three in One” Hemin‐Assisted Cascade Catalysis for Synergetic Cancer Therapy

“…In the XRD spectrum of Bi 2 Se 3 NPs ( Figure 1C), the peaks were well matched with standard value of Bi 2 Se 3 (JCPDS Card no 33-0214). [44,45] Additionally, the high magnitude TEM image of Bi 2 Se 3 ( Figure S5, Supporting Information) showed the lattice distance 0.208 nm, which represents [110] planes of Bi 2 Se 3 . All of the results verified the successful preparation of Bi 2 Se 3 .…”

2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices

“…However, low water dispersibility, difficult functionalization and relatively low biocompatibility of Bi 2 Se 3 has restricted its biomedical applications. Although, Mohammadniaei et al reported that the encapsulation of Bi 2 Se 3 with gold can remarkably overcome those drawbacks [59,60], yet to explore more straight-forward methods.…”