Biflavone Glucosides from Ginkgo biloba Yellow Leaves

Hyun, Sook Kyung; Kang, Sam Sik; Son, Kun Ho; Chung, Hae Young; Choi, Jae Sue

doi:10.1248/cpb.53.1200

Cited by 18 publications

(7 citation statements)

References 19 publications

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“…So far, six biflavones and some of their glycosides have been reported (1–3, 5, 6, 9, 11). In this study, 10 biflavones were detected in the unprocessed leaf samples.…”

Section: Resultsmentioning

confidence: 99%

Chromatographic Profiles and Identification of New Phenolic Components of Ginkgo biloba Leaves and Selected Products

Lin

Chen

Özcan

et al. 2008

J. Agric. Food Chem.

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Ginkgo biloba leaves and their extracts are one of the most widely used herbal products and/or dietary supplements in the world. A systematic study of the phenolic compounds is necessary to establish quality parameters. A modified LC-DAD-ESI/MS method was used to obtain chromatographic profiles for the flavonoids and terpene lactones of Ginkgo biloba leaves. The method was used to identify 45 glycosylated flavonols and flavones, 3 flavonol aglycones, catechin, 10 biflavones, a dihydroxybenzoic acid, and 4 terpene lactones in an aqueous methanol extract of the leaves. The extracted G. biloba leaf products contained the same flavonoids as the raw leaves except for the lack of biflavones. The detected glycosylated flavonol contents were equal to or more than 0.0008% of the dry plant material. This is the first report of the presence of more than 20 of these flavonoids in G. biloba.

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“…So far, six biflavones and some of their glycosides have been reported (1–3, 5, 6, 9, 11). In this study, 10 biflavones were detected in the unprocessed leaf samples.…”

Section: Resultsmentioning

confidence: 99%

Chromatographic Profiles and Identification of New Phenolic Components of Ginkgo biloba Leaves and Selected Products

Lin

Chen

Özcan

et al. 2008

J. Agric. Food Chem.

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“…These authors reported that the Cycadales species including C. revoluta leaflets were free from biflavone glycosides. It is worthwhile to mention that biflavone glycosides are rare natural products; only amentoflavone, ginkgetin and isoginkgetin glycosides were previously reported to occur in the Psilotaceae (Markham 1984), Ferns (Wallace & Markham 1978), Berberidaceae (Naokata et al 1974) and Ginkgoaceae (Hyun et al 2005). Thus, the presence of amentoflavone glucosides in C. revoluta may contribute to the chemotaxonomy of the family Cycadaceae.…”

Section: Resultsmentioning

confidence: 97%

Two new dihydroamentoflavone glycosides fromCycas revoluta

Moawad

Hetta

Zjawiony

et al. 2013

Natural Product Research

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Phytochemical investigation of the ethyl acetate extract of Cycas revoluta Thunb. leaflets afforded five compounds including two new dihydroamentoflavone glucosides, (2S)-I-(2,3)-dihydro-I-7-O-β-D-glucopyranosylamentoflavone (1) and (2S)-I-(2,3)-dihydro-I-7,II-7-di-O-β-D-glucopyranosylamentoflavone (2), in addition to the known compounds prunin (3), vitexin-2″-rhamnoside (4) and protocatechuic acid (5). Compounds (3) and (4) being reported for the first time in this plant. The structures of these compounds were established by the detailed analysis of their spectroscopic data, mainly 1D NMR, 2D NMR, CD and HR-MSD-TOF. The ethyl acetate extract showed weak cytotoxicity against HepG2 (IC50 = 207.6 μg/mL) and RAW 264.2 cells (IC50 = 160.8 μg/mL). Compound 4 showed significant activity towards Leishmania donavani (IC50 = 13.8 μM, IC90 = 34.6 μM). The isolated compounds showed weak antimicrobial activity (IC50>10 μg/mL).

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“…Here, we present the findings of six reports published to date, on the outcome of patients in relation to the order of surgical therapies for IE complicated with SA [2,[6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Infective endocarditis complicated with splenic abscess successfully treated with splenectomy followed by double valve replacement

Naito

Mitani

Ishiwata

et al. 2010

Journal of Cardiology Cases

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Splenic abscess (SA) is a rare complication of infective endocarditis (IE). A successful outcome lies with a choice between medical and surgical treatments. However, there is still insufficient evidence in the decision-making process.Our patient was a 73-year-old male who complained mainly of fever and general fatigue. An echocardiography showed vegetation of 10 mm in diameter and severe mitral and aortic regurgitation and a diagnosis was made of IE. Because of a recent brain embolism, we decided to treat him initially with medical therapy. Antibiotics were effective, but on the 28th day after starting treatment, he complained of left upper abdominal pain. An abdominal computed tomography scan showed SA. The administration of vancomycin did not improve the condition. We decided that he should undergo surgical treatment.A splenectomy was performed and 9 days after the splenectomy, the mitral and aortic valves were successfully replaced.There is still no clear-cut evidence to support the order of surgical interventions. Indeed, the current guidelines, which recommend that splenectomy is to be performed first, are not supported by strong evidence. The present case report showed that splenectomy before valve surgery successfully treated the patient.

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Biflavone Glucosides from Ginkgo biloba Yellow Leaves

Cited by 18 publications

References 19 publications

Chromatographic Profiles and Identification of New Phenolic Components of Ginkgo biloba Leaves and Selected Products

Chromatographic Profiles and Identification of New Phenolic Components of Ginkgo biloba Leaves and Selected Products

Two new dihydroamentoflavone glycosides fromCycas revoluta

Infective endocarditis complicated with splenic abscess successfully treated with splenectomy followed by double valve replacement

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