Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota

Ni, Yingchun; Zhang, Yi; Zheng, Liujie; Rong, Nianke; Yang, Yong; Gong, Peng; Yang, Yi; Siwu, Xuerong; Zhang, Chenyang; Zhu, Lingli; Fu, Zhengwei

doi:10.1016/j.lfs.2023.121699

Cited by 24 publications

(18 citation statements)

References 52 publications

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“…IBD is a chronic and recurrent inflammatory disease of the gastrointestinal tract [ 20 ]. As a typical inflammatory disease, research indicates that immune cell types are involved in the pathogenesis of IBD [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Zebrafish is an ideal model system for human disease and drug development with the advantages of high reproducibility, rapid development, small size, high throughput, low cost and high genetic and morphological similarity with the human counterpart [ 20 , 21 ]. Many studies have reported that zebrafish (Danio rerio) larvae have emerged as a useful tool for the screening and exploration of potential drugs in the treatment of IBD and gastrointestinal diseases [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways

Cao,

Xu,

Xia

et al. 2024

Marine Drugs

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Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with unknown pathogenesis which has been gradually considered a public health challenge worldwide. Peptides derived from Rapana venosa have been shown to have an anti-inflammatory effect. In this study, peptide LLTRAGL derived from Rapana venosa was prepared by a solid phase synthesis technique. The protective effects of LLTRAGL were studied in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced zebrafish colitis model. The underlying mechanisms of LLTRAGL were predicted and validated by transcriptome, real-time quantitative PCR assays and molecular docking. The results showed that LLTRAGL reduced the number of macrophages migrating to the intestine, enhanced the frequency and rate of intestinal peristalsis and improved intestinal inflammatory damage. Furthermore, transcriptome analysis indicated the key pathways (NOD-like receptor signal pathway and necroptosis pathway) that link the underlying protective effects of LLTRAGL’s molecular mechanisms. In addition, the related genes in these pathways exhibited different expressions after TNBS treatment. Finally, molecular docking techniques further verified the RNA-sequencing results. In summary, LLTRAGL exerted protective effects in the model of TNBS-induced colitis zebrafish. Our findings provide valuable information for the future application of LLTRAGL in IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways

Cao,

Xu,

Xia

et al. 2024

Marine Drugs

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“…Studies have shown that these beneficial bacteria play an essential role in protecting the intestinal mucosal barrier, maintaining microbiota homeostasis. 54 Lactobacillus confers improvements in host physiology and blood lipid by maintaining the intestinal barrier against chronic inflammation. 55 Bifidobacterium promote the balance of intestinal flora and suppress the relative abundance of pathogenic bacteria by stimulating the production of bioactive molecules such as short-chain fatty acids, organic acids and vitamins.…”

Section: Food and Function Papermentioning

confidence: 99%

Effects of extracted oil of fermented Tartary buckwheat on lipid-lowering, inflammation modulation, and gut microbial regulation in mice

Yang,

Zhu,

et al. 2023

Food Funct.

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“…Bifidobacterium is a genus of gram-positive, anaerobic bacilli, and they utilize the fructose-6-phosphate phosphoketolase pathway. Lactobacillaceae is a family of long, curved or straight, gram-positive, anaerobic, lactic acid-forming bacilli [ 73 , 74 , 75 , 76 , 77 ]. Of these, Lactiplantibacillus (Lactobacillus) plantarum appears to have the most promising results in the intervention of symptoms associated with neurodegeneration [ 78 , 79 , 80 ].…”

Section: Introductionmentioning

confidence: 99%

Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature

Beltrán-Velasco,

Reiriz,

Uceda

et al. 2024

IJMS

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This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in the symptomatological intervention of neurodegenerative disease. The existence of gut microbiota dysbiosis has been associated with systemic inflammatory processes present in neurodegenerative disease, creating the opportunity for new treatment strategies. This involves modifying the strains that constitute the gut microbiota to enhance synaptic function through the gut–brain axis. Recent studies have evaluated the beneficial effects of the use of Lactiplantibacillus plantarum on motor and cognitive symptomatology, alone or in combination. This systematic review includes 20 research articles (n = 3 in human and n = 17 in animal models). The main result of this research was that the use of Lactiplantibacillus plantarum alone or in combination produced improvements in symptomatology related to neurodegenerative disease. However, one of the studies included reported negative effects after the administration of Lactiplantibacillus plantarum. This systematic review provides current and relevant information about the use of this probiotic in pathologies that present neurodegenerative processes such as Alzheimer’s disease, Parkinson’s disease and Multiple Sclerosis.

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Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota

Cited by 24 publications

References 52 publications

The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways

The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways

Effects of extracted oil of fermented Tartary buckwheat on lipid-lowering, inflammation modulation, and gut microbial regulation in mice

Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature

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