Bidirectional relationships between sleep and biomarkers of stress and immunity in youth

LaVoy, Emily C.; Palmer, Cara A.; So, Christine J.; Alfano, Candice A.

doi:10.1016/j.ijpsycho.2020.10.010

Cited by 24 publications

(40 citation statements)

References 50 publications

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“…The PRISMA flow chart of the reviewing process is shown in Figure 1. The participants in the studies selected were healthy adults, shift workers, adults with obstructive sleep apnea syndrome (OSAS) [40][41][42], adults with advanced stage cancer [43], adults with migraine [44], adults with chronic kidney failure (CRF) [45], and children and adolescent populations among which there were people with diagnoses included in the DSM-V [46,47]. The sample characteristics, sleep instruments, primary outcomes related to salivary biomarkers and sleep alterations are shown in Table 1.…”

Section: Studies Selection and Analysismentioning

confidence: 99%

“…IL-6 was measured in 9 of the 13 articles analyzed [41,43,[45][46][47][48][49][50]52]. According to the study published by Li Zhang et al [49] on nurses who did shift work, IL-6 levels were correlated with the ISI (Insomnia Severity Index).…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

“…According to the studies by Reinhardt et al [48] on workers who worked shifts, day and night workers produced similar amounts of IL-6. LaVoy et al [47] recently carried out a study in children/adolescents, in which they found that the concentration of IL-6 in the morning was associated with the prior night's sleep efficiency and the total amount of minutes spent awake the night after saliva sampling. In the study by Faraut et al [50], IL-6 values fell significantly after a night with only 2 h of sleep, and this effect normalized after a daytime nap of no more than 30 min at 9:30 am and at 15:30 pm.…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

“…Seven of the reviewed articles [41,43,44,[47][48][49]51] analyze the relationship between IL-1β levels in saliva and sleep. In four of them, no significant changes were detected between the study groups in the levels of IL-1β related to sleep [41,43,48,51].…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

“…In two others, there was an increase in IL-1β in saliva. One of them was a study focused on the child-adolescent population [47], and in the other [44] the levels of this cytokine were increased, and PSQI values improved after ten weeks of treatment with nVNS.…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

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Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

et al. 2021

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Poor sleep quality and sleep disorders are the most common problems in people, affecting health-related quality of life. Various studies show an association between sleep disorders and altered levels of stress hormones and inflammatory cytokines measured in saliva. The main objective of this article is to provide an analysis of the current evidence related to changes in inflammatory markers in the saliva and their associations with sleep quality measurement (both objective and subjective methods) in healthy subjects and in sleep-related disorders. To that end, a scoping review was carried out, following the PRISMA criteria in the bibliographic search in several databases: PubMed, EBSCO, and SCOPUS. Eleven of the articles are from the adult population and two from the child-youth population. They mainly measure the relationship between sleep and interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFα) alpha, as well as other inflammatory markers such as myeloperoxidase (MPO) and prostaglandin-endoperoxide synthase 2. An analysis shows the relationship between these salivary biomarkers and sleep quality, especially in the case of IL-6 in both healthy subjects and several pathologies associated with sleep-disorders. The results for TNFα and IL-1β measurements are still inconclusive and the difference with IL-6 was assessed. Two studies reported interventions that result in sleep improvement and are accompanied by the normalization of inflammatory changes detected in the saliva. As it is an easy-to-apply and non-invasive method, the measurement of salivary cytokines can be very useful in chronobiology studies. Further studies are required to determine the sensitivity of salivary inflammatory markers in monitoring biological rhythms and acting as biomarkers in the detection of sleep disorders and sleep interventions.

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Section: Studies Selection and Analysismentioning

confidence: 99%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

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Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

et al. 2021

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Possible utilization of salivary IFN‐γ/IL‐4 ratio as a marker of chronic stress in healthy individuals

Takemori

Sasayama

Toida

et al. 2021

Neuropsychopharm Rep

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Introduction Several studies show that psychological stress reduces Th1/Th2 ratio in blood samples. However, evidence is scarce regarding the cytokine alterations during stress in saliva. We investigated the influence of chronic stress on Th1/Th2 ratio and cytokine profiles in the saliva of healthy individuals. Further, we examined the associations of the salivary cytokine levels with sleep and attention problems, which are closely related with psychological stress. Methods Salivary levels of 27 cytokines were measured by multiplex bead array assays in 31 healthy young individuals (health science students and hospital staff consisting of 11 men and 20 women, mean age [standard deviation] =21.5 [0.8] years). The Kessler Psychological Distress scale (K10) and Athens Insomnia Scale (AIS) were administered to assess subjective chronic psychological stress and sleep problems. Further, participants were asked to wear Actigraph GT3X accelerometers for 3 days to assess the total sleep time. Attention problems were assessed by administering the Integrated Visual and Auditory Continuous Performance Test (IVA‐CPT). Results Thirteen cytokines with >80% detectable results were included in the main analyses. The IFN‐γ/IL‐4 ratio, which is a commonly used index for Th1/Th2 ratio, showed significant negative correlations with the K10 and AIS scores. None of the cytokines were significantly associated with sex, body mass index, sleep index measured by Actigraph, or IVA‐CPT scores. Conclusion Chronic stress may be associated with alterations of the Th1/Th2 balance in salivary cytokine production. IFN‐γ/IL‐4 ratio in saliva may serve as a potential biomarker of chronic stress in healthy individuals.

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Sleep duration trajectories associated with levels of specific serum cytokines at age 5: A longitudinal study in preschoolers from the EDEN birth cohort

Radmanish

Khalfallah

Glaichenhaus

et al. 2022

Brain, Behavior, & Immunity - Health

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Bidirectional relationships between sleep and biomarkers of stress and immunity in youth

Cited by 24 publications

References 50 publications

Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

Possible utilization of salivary IFN‐γ/IL‐4 ratio as a marker of chronic stress in healthy individuals

Sleep duration trajectories associated with levels of specific serum cytokines at age 5: A longitudinal study in preschoolers from the EDEN birth cohort

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