Bidirectional communication between mast cells and the gut-brain axis in neurodegenerative diseases: Avenues for therapeutic intervention

Bhuiyan, Piplu; Chen, Yinan; Karim, Mazharul; Dong, Huijuan; Qian, Yanning

doi:10.1016/j.brainresbull.2021.04.010

Cited by 18 publications

(9 citation statements)

References 323 publications

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“…GABA, an important inhibitory neurotransmitter in CNS, is closely related to emotion and memory, and can also affect visceral sensitivity. Recent studies have found that Citrobacter might motivate the activity of the VN pathway, which regulated the rapid activation of brain areas including nuclear loneliness and the extracellular and amygdala of visceral sensation and anxiety, indicating that the nervous system could sense acute intestinal changes and discern the presence of pathogens (Bhuiyan et al, 2021). The gut has a direct neural connection with the brain through VN.…”

Section: Pathways Of Communi C Ati On Along the G Bamentioning

confidence: 99%

The interaction effect between tea polyphenols and intestinal microbiota: Role in ameliorating neurological diseases

Hong

Zhang

Liu

et al. 2021

Journal of Food Biochemistry

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Tea polyphenols (TP) are one of the most functional and bioactive substances in tea.The interactions between TP and intestinal microbiota suggest that probiotics intervention is a useful method to ameliorate neurological diseases. Now, numerous researches have suggested that TP plays a significant role in modulating intestinal bacteria, especially in the area of sustaining a stable state of intestinal microbial function and abundance. Furthermore, homeostatic intestinal bacteria can enhance the immunity of the host. The close reciprocity between intestinal microbiota and the central nervous system provides a new chance for TP to modulate neural-related diseases depending on intestinal microbiota. Therefore, based on the bidirectional relationship between the brain and the intestines, this review provides a new clue to solve insomnia symptoms and related neurological diseases that will enable us to better study the bidirectional effects of TP and intestinal microbiota on the improvement of host health. Practical applicationsThis review provides a new clue to solve insomnia symptoms and related neurological diseases that will enable us to better study bidirectional effects of TP and intestinal microbiota on the improvement of host health.

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Section: Pathways Of Communi C Ati On Along the G Bamentioning

confidence: 99%

The interaction effect between tea polyphenols and intestinal microbiota: Role in ameliorating neurological diseases

Hong

Zhang

Liu

et al. 2021

Journal of Food Biochemistry

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“…The aberrant accumulation of specific proteins, such as TDP-43 [16] and SOD1 [17] in ALS, amyloid β [18] and Tau [19] in AD, and α-synuclein [20] in PD, with similar proteinopathies seen in the chronic stage of ischemic stroke [21] can initiate a cascade of deleterious innate immunity processes that may contribute to the dysbiotic and dysfunctional GBA pathophysiological manifestations of NDDs. Recent review papers highlight the interaction between GBA and NDDs, with emphasis on diet, exercise, prebiotics and probiotics as treatments towards maintaining healthy microbiota in GBA [22][23][24][25][26][27]. Here, we chose to probe the underexplored use of stem cells for improving the microbiota in NDDs.…”

Section: Introductionmentioning

confidence: 99%

Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders

Toledo

Monroy

Salazar

et al. 2022

IJMS

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Human lifestyle and dietary behaviors contribute to disease onset and progression. Neurodegenerative diseases (NDDs), considered multifactorial disorders, have been associated with changes in the gut microbiome. NDDs display pathologies that alter brain functions with a tendency to worsen over time. NDDs are a worldwide health problem; in the US alone, 12 million Americans will suffer from NDDs by 2030. While etiology may vary, the gut microbiome serves as a key element underlying NDD development and prognosis. In particular, an inflammation-associated microbiome plagues NDDs. Conversely, sequestration of this inflammatory microbiome by a correction in the dysbiotic state of the gut may render therapeutic effects on NDDs. To this end, treatment with short-chain fatty acid-producing bacteria, the main metabolites responsible for maintaining gut homeostasis, ameliorates the inflammatory microbiome. This intimate pathological link between the gut and NDDs suggests that the gut-brain axis (GBA) acts as an underexplored area for developing therapies for NDDs. Traditionally, the classification of NDDs depends on their clinical presentation, mostly manifesting as extrapyramidal and pyramidal movement disorders, with neuropathological evaluation at autopsy as the gold standard for diagnosis. In this review, we highlight the evolving notion that GBA stands as an equally sensitive pathological marker of NDDs, particularly in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and chronic stroke. Additionally, GBA represents a potent therapeutic target for treating NDDs.

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“…Intestinal macrophages phagocytose bacteria and pathogens that attempt to cross the epithelium, and they interface with SMCs and enteric neurons via bone morphogenetic protein 2 (BMP2) and bone morphogenetic protein receptor to regulate colonic contractility and peristalsis, respectively [ 49 , 50 ]. Mast cells (MCs) are also present throughout all layers of the GI tract and help to maintain intestinal homeostasis [ 51 ]. MCs release a variety of mediators during degranulation such as tryptase, histamine, serotonin, and cytokines, which regulate GI function by stimulating epithelial cells, intestinal macrophages, and enteric neurons [ 52 ].…”

Section: Key Cellular Players Of Gastrointestinal Motilitymentioning

confidence: 99%

Tissue engineering of the gastrointestinal tract: the historic path to translation

2022

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The gastrointestinal (GI) tract is imperative for multiple functions including digestion, nutrient absorption, and timely waste disposal. The central feature of the gut is peristalsis, intestinal motility, which facilitates all of its functions. Disruptions in GI motility lead to sub-optimal GI function, resulting in a lower quality of life in many functional GI disorders. Over the last two decades, tissue engineering research directed towards the intestine has progressed rapidly due to advances in cell and stem-cell biology, integrative physiology, bioengineering and biomaterials. Newer biomedical tools (including optical tools, machine learning, and nuanced regenerative engineering approaches) have expanded our understanding of the complex cellular communication within the GI tract that lead to its orchestrated physiological function. Bioengineering therefore can be utilized towards several translational aspects: (i) regenerative medicine to remedy/restore GI physiological function; (ii) in vitro model building to mimic the complex physiology for drug and pharmacology testing; (iii) tool development to continue to unravel multi-cell communication networks to integrate cell and organ-level physiology. Despite the significant strides made historically in GI tissue engineering, fundamental challenges remain including the quest for identifying autologous human cell sources, enhanced scaffolding biomaterials to increase biocompatibility while matching viscoelastic properties of the underlying tissue, and overall biomanufacturing. This review provides historic perspectives for how bioengineering has advanced over time, highlights newer advances in bioengineering strategies, and provides a realistic perspective on the path to translation.

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Bidirectional communication between mast cells and the gut-brain axis in neurodegenerative diseases: Avenues for therapeutic intervention

Cited by 18 publications

References 323 publications

The interaction effect between tea polyphenols and intestinal microbiota: Role in ameliorating neurological diseases

The interaction effect between tea polyphenols and intestinal microbiota: Role in ameliorating neurological diseases

Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders

Tissue engineering of the gastrointestinal tract: the historic path to translation

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