The interaction effect between tea polyphenols and intestinal microbiota: Role in ameliorating neurological diseases

Abstract

Tea polyphenols (TP) are one of the most functional and bioactive substances in tea.The interactions between TP and intestinal microbiota suggest that probiotics intervention is a useful method to ameliorate neurological diseases. Now, numerous researches have suggested that TP plays a significant role in modulating intestinal bacteria, especially in the area of sustaining a stable state of intestinal microbial function and abundance. Furthermore, homeostatic intestinal bacteria can enhance the immunity of the host. The close reciprocity between intestinal microbiota and the central nervous system provides a new chance for TP to modulate neural-related diseases depending on intestinal microbiota. Therefore, based on the bidirectional relationship between the brain and the intestines, this review provides a new clue to solve insomnia symptoms and related neurological diseases that will enable us to better study the bidirectional effects of TP and intestinal microbiota on the improvement of host health. Practical applicationsThis review provides a new clue to solve insomnia symptoms and related neurological diseases that will enable us to better study bidirectional effects of TP and intestinal microbiota on the improvement of host health.

A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus

“…The stable and elastic symbiotic relationship between intestinal immune system and microflora affects host health [ 90 ]. Intestinal mucosal immune system is one of the components of intestinal microecology.…”

Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

“…Contrarily, fecal microbiota coming from intact rats transplanted to chronically stressed rats significantly reduced depression- and anxiety-like behaviors and anhedonia, which was associated with the suppressed activation of glial cells and the NLRP3 inflammasome in the brain [ 69 ]. Interestingly, polyphenols may regulate the composition of the gut microbiota, promoting beneficial effects on the intestinal microbiota and inhibiting the proliferation of harmful bacteria; thereby maintaining intestinal health and ameliorating some neurological and neuropsychic disorders [ 70 , 71 ]. This is important because a correct structure of gut microbiota in addition to an anti-inflammatory effect of diverse molecules, including polyphenols, has been associated with its antidepressant-like effects [ 72 ].…”

Integrative Role of Albumin: Evolutionary, Biochemical and Pathophysiological Aspects

“…The need for the development of standardized methods for determining the rate of consumption of AGE is rightly indicated. Numerous studies have shown that polyphenols largely determine the number, composition and condition of intestinal bacteria, which, in turn, modulate neurological diseases [ 214 ]. Polyphenols have not only antioxidant properties, but also the ability to protect proteins from glycation (antiglycating ability).…”