Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats

Abstract

BackgroundEssential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate extract (Bp) on L-NAME induced hypertension and oxidative stress in rats.MethodsMale Wistar rats were used to induce hypertension by the administration of L-NAME (a non-pecific nitric oxide inhibitor) (50 mg/kg/day). The others groups were receiving concomitantly L-NAME plus Bp extract (75 and 150 mg/kg/day) or losartan (25 mg/kg/day). All the treatments were given orally for 4 weeks. At the end of the treatment, the hemodynamic parameters were recorded using the direct cannulation method. The effects of the extract on lipid profile, kidney and liver functions as well as oxidative stress markers were evaluated by colorimetric method. Results were expressed as the mean ± SEM. The difference between the groups was compared using one-way analysis of variance (ANOVA) followed by the Duncan’s post hoc test.ResultsAnimals receiving L-NAME presented high blood pressure, normal heart rate and lipid profile as well as NO depletion, liver and kidney injuries and oxidative stress. The concomitant treatment with L-NAME and Bp or losartan succeeded to prevent the raised of blood pressure and all the other injuries without affecting the heart rate.ConclusionThese results confirm the antihypertensive effects of Bidens pilosa and highlight its protective properties in L-NAME model of hypertension in rat, probably due to the presence of Quercetin 3,3 ‘-dimethyl ether 7–0-β-D-glucopyranoside.Electronic supplementary materialThe online version of this article (10.1186/s12906-017-1972-0) contains supplementary material, which is available to authorized users.

Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat

“…Ethanol treated rats showed a significant decrease in HDL-cholesterol and increase in total cholesterol, triglycerides, and LDL-cholesterol levels as well as the atherogenic index. These findings are in agreement with results obtained by some authors who reported that hypercholesterolemia and dyslipidemia are associated with the pathogenesis of hypertension induced by chronic ethanol and sucrose intake or L-NAME [20, 21]. According to Stevens et al [22], dyslipidemia is a major risk factor for atherosclerosis that promotes increased vascular resistance and contributes to increased blood pressure.…”

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

“…In this study, animals receiving simultaneous administration of L-NAME and HSCE showed lower systolic blood pressure as compared with animals receiving only L-NAME. Similar data were reported for Nitraria sibirica (Senejouxa et al, 2012), Bidens pilosa (Bilanda et al, 2017), Ulmus wallichiana (Syeda et al, 2016), Antidesma thwaitesianum (Kukongviriyapan et al, 2015), plants with NO-mediated hypotensive effect. The in vitro studies using the MVB preparation pre-contracted by Phen also support that the vasorelaxant mechanism of lythrine is likely to be mediated by activation of NO release from vascular endothelium, since the removal of endothelial cells led to absence of the response to HSCE.…”

Profiling of Altered Metabolomic States in Bidens pilosa Leaves in Response to Treatment by Methyl Jasmonate and Methyl Salicylate

“…Bidens pilosa L. ( B. pilosa ) is a cosmopolitan weed occurring mostly in hot tropical areas including sub-Saharan Africa, where it is a widely consumed leafy green vegetable source [ 1 , 2 ]. This plant is not only recognized for its nutritional value, but also for its pharmacological and bio-medical importance [ 3 , 4 ].…”