Bicyclic peptides: types, synthesis and applications

Ahangarzadeh, Shahrzad; Kanafi, Mohammad M.; Hosseinzadeh, Simzar; Mokhtarzadeh, Ahad; Barati, Mahmood; Ranjbari, Javad; Tayebi, Lobat

doi:10.1016/j.drudis.2019.05.008

Cited by 38 publications

(26 citation statements)

References 60 publications

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“…Here, peptide therapy has emerged as a viable treatment option for solid tumors, especially breast cancer. Peptides are attractive treatments because of their precise attachment to the surface of tumor cells, low molecular weight, and low toxicity to normal cells [ 37 , 38 ].…”

Section: Peptide-based Strategies For Targeted Breast Cancermentioning

confidence: 99%

Anti-cancer peptide-based therapeutic strategies in solid tumors

et al. 2022

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Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively. Result Introducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology. Conclusion This study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed.

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Section: Peptide-based Strategies For Targeted Breast Cancermentioning

confidence: 99%

Anti-cancer peptide-based therapeutic strategies in solid tumors

et al. 2022

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“…[ 29 ] Considering the biopotential of natural cyclooligopeptides including bicyclic peptides, these bioactive metabolites are synthesized in the laboratory by various research groups. [ 14,30–37 ] Bioactive bicyclic peptides are obtained from lithistid sponge Aciculites orientalis and Theonella sp., including Red Sea sponge Theonella swinhoei . Aciculitins A–C ( 15 – 17 ), theonellamides A–G ( 18 – 24 ), theonegramide ( 25 ), theopalauamide ( 26 ), and isotheopalauamide ( 27 ) are the best examples of bicyclic peptides from marine sponges.…”

Section: Bioactive Bridged Macrobicyclic Peptides From Marine Spongesmentioning

confidence: 99%

“…In addition, each ring in the bicyclic structure can function independently, allowing these peptides to be bifunctional. [ 6,14 ]…”

Section: Introductionmentioning

confidence: 99%

Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources

Dahiya

Kumar

et al. 2021

Archiv der Pharmazie

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Among peptide‐based drugs, naturally occurring bicyclic compounds have been established as molecules with unique therapeutic potential. The diverse pharmacological activities associated with bicyclic peptides from marine tunicates, sponges, and bacteria render them suitable to be employed as effective surrogate between complex and small therapeutic moieties. Bicyclic peptides possess greater conformational rigidity and higher metabolic stability as compared with linear and monocyclic peptides. The antibody‐like affinity and specificity of bicyclic peptides enable their binding to the challenging drug targets. Bridged macrobicyclic peptides from natural marine resources represent an underexplored class of molecules that provides promising platforms for drug development owing to their biocompatibility, similarity, and chemical diversity to proteins. The present review explores major marine‐derived bicyclic peptides including disulfide‐bridged, histidinotyrosine‐bridged, or histidinoalanine‐bridged macrobicyclic peptides along with their structural characteristics, synthesis, structure–activity relationship, and bioproperties.The comparison of these macrobicyclic congeners with linear/monocyclic peptides along with their therapeutic potential are also briefly discussed.

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“…One of the most effective ways to increase the stability of peptides is the synthesis of cyclic peptides. These peptides are resistant to exonucleases due to the lack of N-terminals and C-terminals, and it has also been found that their circular shape and specific conformation are more efficient in terms of Gibbs free energy for bonding with targets [ 27 ]. Modifications to one of the epidermal growth factor receptor (EGFR) domains and cyclic peptide production, for example, were used to create a cytotoxic state for cancer cells [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the role of peptides in effective therapies against cancer

2022

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Early diagnosis and effective treatment of cancer are challenging. To diagnose and treat cancer effectively and to overcome these challenges, fundamental innovations in traditional diagnosis and therapy are necessary. Peptides can be very helpful in this regard due to their potential and diversity. To enhance the therapeutic potential of peptides, their limitations must be properly identified and their structures engineered and modified for higher efficiency. Promoting the bioavailability and stability of peptides is one of the main concerns. Peptides can also be effective in different areas of targeting, alone or with the help of other therapeutic agents. There has been a lot of research in this area, and the potential for variability of peptides will continue to improve this process. Another promising area in which peptides can help treat cancer is peptide vaccines, which are undergoing promising research, and high throughput technologies can lead to fundamental changes in this area. Peptides have been effective in almost all areas of cancer treatment, and some have even gone through clinical phases. However, many barriers need to be overcome to reach the desired point. The purpose of this review is to evaluate the mechanisms associated with peptides in the diagnosis and treatment of cancer. Therefore, related studies in this area will be discussed.

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Bicyclic peptides: types, synthesis and applications

Abstract: This paper is NOT THE PUBLISHED VERSION; but the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation below.

Cited by 38 publications

References 60 publications

Anti-cancer peptide-based therapeutic strategies in solid tumors

Anti-cancer peptide-based therapeutic strategies in solid tumors

Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources

Investigating the role of peptides in effective therapies against cancer

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