Anti-cancer peptide-based therapeutic strategies in solid tumors

Fath, Mohsen Karami; Zokaei, Maryam; Yaghoubian, Azadeh; Akbari, Sadaf; Khorsandi, Mahdieh; Soofi, Asma; Nabi‐Afjadi, Mohsen; Zalpoor, Hamidreza; Jalalifar, Fateme; Azargoonjahromi, Ali; Payandeh, Zahra; Bahrami, Armina Alagheband

doi:10.1186/s11658-022-00332-w

Cited by 64 publications

(61 citation statements)

References 193 publications

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“…It has been demonstrated that shikonin (a naphthoquinone pigment extracted from the dried root of Zicao ( Lithospermum erythrorhizon, Onosma paniculata, or Arnebia euchroma, as a traditional Chinese herbal medicine) could block the phosphorylation of STAT3, decrease the levels of STAT3-targeted genes involved in melanoma survival and migration (Mcl-1, Bcl-2, MMP-2), and finally suppress melanoma growth [ 51 , 52 ]. In a different study, the inhibition of the viability and proliferation of A375 and A2058 melanoma cells was shown by the dauricine via blocking the phosphorylation-mediated activation of STAT3 and Src in a dose-dependent manner [ 34 , 53 – 55 ]. Recently, Meng et al have also evaluated the potent anti-melanoma activity of podocarpusflavone A (PCFA).…”

Section: Pathways and Different Risk Factors Involved In Melanoma Occ...mentioning

confidence: 99%

Current understanding of epigenetics role in melanoma treatment and resistance

et al. 2022

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Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes in mechanisms of cell growth and proliferation. Epigenetics is the other factor with a crucial role in melanoma development. Epigenetic changes have become novel targets for treating patients suffering from melanoma. These changes can alter the expression of microRNAs and their interaction with target genes, which involves cell growth, differentiation, or even death. Given these circumstances, we conducted the present review to discuss the melanoma risk factors and represent the current knowledge about the factors related to its etiopathogenesis. Moreover, various epigenetic pathways, which are involved in melanoma progression, treatment, and chemo-resistance, as well as employed epigenetic factors as a solution to the problems, will be discussed in detail.

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Section: Pathways and Different Risk Factors Involved In Melanoma Occ...mentioning

confidence: 99%

Current understanding of epigenetics role in melanoma treatment and resistance

et al. 2022

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“…Glioblastoma multiforme (GBM) is a malignant tumor of connective tissue, and has been known as the most deadly primary brain tumor [ 1 , 39 – 41 ]. Flavonoids such as quercetin are able to cross the blood–brain barrier (BBB) via different mechanisms, including carrier-mediated transcellular transport transcellular diffusion or paracellular distribution via tight junctions between BBB endothelial cells [ 1 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

et al. 2022

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The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and neurodegeneration. Owing to the complexity of this pathway and its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, the majority of JAK–STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK–STAT pathway through known and unknown mechanisms. Quercetin has shown prominent inhibitory effects on the JAK–STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases. This review discusses the pharmacological effects of quercetin on the JAK–STAT signaling pathway in solid tumors and neurodegenerative diseases.

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“…A change in this signaling pathway can influence pathological processes due to its important role in the regulation of biological processes because a malfunctioning of Janus kinase, JAK signal converter, and STAT signaling can lead to tumor formation [ 17 ]. Glioblastoma is a prevalent primary brain tumor in humans, and a highly infiltrative and extremely aggressive astrocytoma, which is characterized by resistance to apoptosis by radiation and chemotherapeutic treatments [ 7 , 24 ]. Several studies indicate that JAK/STAT signaling pathways are involved in the progression, migration, and invasion of glioblastoma.…”

Section: Jak/stat Signaling Pathways and Glioblastomamentioning

confidence: 99%

The Role of Natural Products as Inhibitors of JAK/STAT Signaling Pathways in Glioblastoma Treatment

Fahmideh

Shapourian

Molatefi

et al. 2022

Oxidative Medicine and Cellular Longevity

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The permeability of glioblastoma, as well as its escaping the immune system, makes them one of the most deadly human malignancies. By avoiding programmed cell death (apoptosis), unlimited cell growth and metastatic ability could dramatically affect the immune system. Genetic mutations, epigenetic changes, and overexpression of oncogenes can cause this process. On the other hand, the blood-brain barrier (BBB) and intratumor heterogeneity are important factors causing resistance to therapy. Several signaling pathways have been identified in this field, including the Janus tyrosine kinase (JAK) converter and signal transducer and activator of transcription (STAT) activator pathways, which are closely related. In addition, the JAK/STAT signaling pathway contributes to a wide array of tumorigenesis functions, including replication, anti-apoptosis, angiogenesis, and immune suppression. Introducing this pathway as the main tumorigenesis and treatment resistance center can give a better understanding of how it operates. In light of this, it is an important goal in treating many disorders, particularly cancer. The inhibition of this signaling pathway is being considered an approach to the treatment of glioblastoma. The use of natural products alternatively to conventional therapies is another area of research interest among researchers. Some natural products that originate from plants or natural sources can interfere with JAK/STAT signaling in human malignant cells, also by stopping the progression and phosphorylation of JAK/STAT, inducing apoptosis, and stopping the cell cycle. Natural products are a viable alternative to conventional chemotherapy because of their cost-effectiveness, wide availability, and almost no side effects.

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Anti-cancer peptide-based therapeutic strategies in solid tumors

Cited by 64 publications

References 193 publications

Current understanding of epigenetics role in melanoma treatment and resistance

Current understanding of epigenetics role in melanoma treatment and resistance

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

The Role of Natural Products as Inhibitors of JAK/STAT Signaling Pathways in Glioblastoma Treatment

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